Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis Regulating the MAPK/NF-κB-Autophagy Pathway.

Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonstrated that cepharanthine (CEP), extracted from the plant , exerted protective medicinal efficacy on osteoarthritis for the first time.