[Scientific connotation in processing of Aconiti Lateralis Radix Praeparata with Glycyrrhizae Radix et Rhizoma based on "interactions between excipients and herbal medicine and component transformation" dynamic processing].

The processing of traditional Chinese medicine(TCM) is a core theory within TCM, embodying deep philosophical, cultural, and natural scientific wisdom. Among the various techniques, the "synergistic processing of medicinal materials and excipients" has garnered significant attention due to its uniqueness. This study explored the impact of the adjuvant Glycyrrhizae Radix et Rhizoma on the dynamic process of component transformation during the processing of Aconiti Lateralis Radix Praeparata using techniques such as acidic dye colorimetry, UPLC-Q-TOF-MS/MS, density functional theory(DFT), and molecular dynamics simulations(MDS).

[Comparison on material basis between single and co-decoctions of Rhei Radix et Rhizoma and Coptidis Rhizoma by supramolecular chemistry].

This study employed supramolecular chemistry of traditional Chinese medicine to compare the material basis between different decocting methods(co-decocting and single decocting) and explained the chemical basis of Rhei Radix et Rhizoma-Coptidis Rhizoma in alleviating the disadvantage of bitter and cold medicines damaging the stomach. The spectroscopic differences between the co-decoction and single decoctions were characterized by ultraviolet-visible absorption spectrum, infrared spectrum, and circular dichroism spectrum. Five characteristic alkaloids, such as berberine, were selected as the indicators to compare the sample solubility and dissolution of medicinal components between the co-decoction and single decoctions by high performance liquid chromatography.

Chiral helix amplification and enhanced bioadhesion of two-component low molecular weight hydrogels regulated by OH to eradicate MRSA biofilms.

The supramolecular chemistry of small chiral molecules has attracted widespread attention owing to their similarity to natural assembly codes. Two-component low-molecular-weight (LMW) hydrogels are crucial as they form helical structures chirality transfer, enabling diverse functions. Herein, we report a pair of two-component chiral LMW hydrogels based on the small molecular drugs baicalin (BA), scutellarin (SCU) and berberine (BBR).

Nomogram for assistant diagnosing acute suppurative cholangitis: a case-control study.

Background: Acute suppurative cholangitis (ASC) lacks sensitive and specific preoperative diagnostic criteria. Some researchers suggest treating ASC as severe cholangitis. This study aimed to explore the relationship between the Tokyo Guidelines 2018 (TG18) grading system for acute cholangitis (AC) and the diagnosis of acute suppurative cholangitis (ASC), searching for independent risk factors of ASC and develop a nomogram to discriminate ASC from acute nonsuppurative cholangitis (ANSC) accurately.

Functional Ginger-Derived Extracellular Vesicles-Coated ZIF-8 Containing TNF-α siRNA for Ulcerative Colitis Therapy by Modulating Gut Microbiota.

Tumor necrosis factor-α (TNF-α) plays a causal role in the pathogenesis of ulcerative colitis (UC), and anti-TNF-α siRNA shows great promise in UC therapy. However, delivering siRNA with site-targeted stability and therapeutic efficacy is still challenging due to the complex and dynamic intestinal microenvironment. Here, based on the functional plant-derived ginger extracellular vesicles (EVs) and porous ZIF-8 nanoparticles, we propose a novel TNF-α siRNA delivery strategy (EVs@ZIF-8@siRNA) for UC targeted therapy.

C Fullerene-Induced Reduction of Metal Ions: Synthesis of C-Metal Cluster Heterostructures with High Electrocatalytic Hydrogen-Evolution Performance.

Metal clusters, due to their small dimensions, contain a high proportion of surface atoms, thus possessing a significantly improved catalytic activity compared with their bulk counterparts and nanoparticles. Defective and modified carbon supports are effective in stabilizing metal clusters, however, the synthesis of isolated metal clusters still requires multiple steps and harsh conditions. Herein, we develop a C fullerene-driven spontaneous metal deposition process, where C serves as both a reductant and an anchor, to achieve uniform metal (Rh, Ir, Pt, Pd, Au and Ru) clusters without the need for any defects or functional groups on C.

Integrating network pharmacology, bioinformatics, and experimental validation to unveil the molecular targets and mechanisms of galangin for treating hepatocellular carcinoma.

Background: Galangin, a flavonoid compound, is derived from Alpinia officinarum Hance. Previous studies have shown that galangin can inhibit the proliferation of hepatocellular carcinoma (HCC), but its mechanism is still unclear. This study aims to investigate the potential targets and molecular mechanisms of galangin on HCC through network pharmacology, bioinformatics, molecular docking, and experimental in vitro validation.

HNF4A-Bridging the Gap Between Intestinal Metaplasia and Gastric Cancer.

Background: Intestinal metaplasia (IM) of gastric epithelium has traditionally been regarded as an irreversible stage in the process of the Correa cascade. Exploring the potential molecular mechanism of IM is significant for effective gastric cancer prevention.

Methods: The GSE78523 dataset, obtained from the Gene Expression Omnibus (GEO) database, was analyzed using RStudio software to identify the differently expressed genes (DEGs) between IM tissues and normal gastric epithelial tissues.

The degree of population aging and living carbon emissions: Evidence from China.

Population aging and global warming have become everyday concerns of all countries. Based on the panel data of 30 provinces in China from 2003 to 2019, this paper uses the panel fixed effect model and two-stage least square method to analyze the effect of population aging on domestic energy carbon emissions of urban and rural residents. On this basis, the threshold regression model is introduced to explore the heterogeneity of the effect under different aging levels.

Spatio-Temporal Feature Transformation Based Polyp Recognition for Automatic Detection: Higher Accuracy than Novice Endoscopists in Colorectal Polyp Detection and Diagnosis.

Background: Artificial intelligence represents an emerging area with promising potential for improving colonoscopy quality.

Aims: To develop a colon polyp detection model using STFT and evaluate its performance through a randomized sample experiment.

Methods: Colonoscopy videos from the Digestive Endoscopy Center of the First Affiliated Hospital of Anhui Medical University, recorded between January 2018 and November 2022, were selected and divided into two datasets.

Identification of the function of in cholangiocarcinoma using bioinformatics analysis.

Background: Exploring the potential mechanism of cholangiocarcinoma (CCA) metabolic reprogramming is significant for guiding clinical treatment. However, related research and exploration are still lacking. Therefore, we aimed to identify a reliable metabolism-related gene or biomarker of CCA using bioinformatics analysis.

MicroRNA-140-3p inhibits proliferation and promotes apoptosis in non-small cell lung cancer by targeting MDIG.

Background: MicroRNAs (miRNAs) are associated with cancer progression. MiR-140-3p is a tumor suppressor. Nevertheless, its function in non-small cell lung cancer (NSCLC) is unclear.

Emerging role of autophagy in colorectal cancer: Progress and prospects for clinical intervention.

Autophagy is a physiological mechanism in which cells degrade themselves and quickly recover the degraded cell components. Recent studies have shown that autophagy plays an important role in the occurrence, development, treatment, and prognosis of colorectal cancer. In the early stages of colorectal cancer, autophagy can inhibit the production and development of tumors through multiple mechanisms such as maintaining DNA stability, inducing tumor death, and enhancing immune surveillance.

Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.

Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) with various etiologies, which seriously affects the structure and function of the kidney. Pregnane X receptor (PXR) is a member of the nuclear receptor superfamily and plays a critical role in regulating the genes related to xenobiotic and endobiotic metabolism in mammals. Previous studies show that PXR is expressed in the kidney and has protective effect against acute kidney injury (AKI).

The Influence of Foreign Direct Investment on Physical Health of Rural-Urban Migrants-Empirical Evidence from China Migrants Dynamic Survey.

The purpose of this study is to explore the influence of Foreign Direct Investment (FDI) on rural-urban migrants' physical health and its influencing mechanism. A total of 134,920 rural-urban migrant samples are matched based on the China Migrants Dynamic Survey in 2017 and the China Urban Statistical Yearbook in 2016. On the basis of the samples, a Binary Probit Model is used to explore the relationship between the degree of FDI and rural-urban migrants' physical health.

Point and interval forecasting for carbon trading price: a case of 8 carbon trading markets in China.

Carbon trading price (CTP) prediction accuracy is critical for both market participants and policymakers. As things stand, most previous studies have only focused on one or a few carbon trading markets, implying that the models' universality is insufficient to be validated. By employing a case study of all carbon trading markets in China, this study proposes a hybrid point and interval CTP forecasting model.

Combined spectral and speech features for pig speech recognition.

The sound of the pig is one of its important signs, which can reflect various states such as hunger, pain or emotional state, and directly indicates the growth and health status of the pig. Existing speech recognition methods usually start with spectral features. The use of spectrograms to achieve classification of different speech sounds, while working well, may not be the best approach for solving such tasks with single-dimensional feature input.

Hierarchical medical system and local medical performance: A quasi-natural experiment evaluation in Shanghai, China.

Background: In order to maintain high standards of healthcare, it is necessary for medical departments to provide high-quality and affordable medical services to local residents. This has been widely accepted in developed countries, while the medical treatment systems in developing countries remain to be improved. This research is based on a pilot of a hierarchical medical system in Shanghai, China, to evaluate the effects on policy of medical reform in developing countries.

Methionine restriction - Association with redox homeostasis and implications on aging and diseases.

Methionine is an essential amino acid, involved in the promotion of growth, immunity, and regulation of energy metabolism. Over the decades, research has long focused on the beneficial effects of methionine supplementation, while data on positive effects of methionine restriction (MR) were first published in 1993. MR is a low-methionine dietary intervention that has been reported to ameliorate aging and aging-related health concomitants and diseases, such as obesity, type 2 diabetes, and cognitive disorders.

Bio-Inspired 4D Printing of Dynamic Spider Silks.

Spider silks exhibit excellent mechanical properties and have promising application prospects in engineering fields. Because natural spider silk fibers cannot be manufactured on a large scale, researchers have attempted to fabricate bio-inspired spider silks. However, the fabrication of bio-inspired spider silks with dynamically tunable mechanical properties and stimulation-response characteristics remains a challenge.

Value quantification of multiple energy storage to low-carbon combined heat and power system.

As the proportion of renewable energy gradually increases, it brings challenges to the stable operation of the combined heat and power (CHP) system. As an important flexible resource, energy storage (ES) has attracted more and more attention. However, the profit of energy storage can't make up for the investment and operation cost, and there is a lack of measurement system for multiple values, which seriously hinders the development of energy storage industry.

[Effects of transcranial magneto-acoustic electrical stimulation on calcium signals in prefrontal nerve clusters].

Transcranial magneto-acoustic electrical stimulation (TMAES) is a novel method of brain nerve regulation and research, which uses induction current generated by the coupling of ultrasound and magnetic field to regulate neural electrical activity in different brain regions. As the second special envoy of nerve signal, calcium plays a key role in nerve signal transmission. In order to investigate the effect of TMAES on prefrontal cortex electrical activity, 15 mice were divided into control group, ultrasound stimulation (TUS) group and TMAES group.

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function.

Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that modulate various cellular functions. Mitochondrial dysfunction has been described as an early feature of brain aging and neurodegeneration.