Reflective analysis on the current I adjuvant therapy indications in intermediate- and high-risk differentiated thyroid cancer.

Purpose: Radioiodine (I) adjuvant therapy (RAT) is given to treat subclinical tumor of differentiated thyroid cancer (DTC) that may or may not actually be present after prior adequate treatment, yet the indications and benefits for RAT remain controversial. This multi-center study retrospectively evaluated the real targets and responses to RAT in intermediate- and high-risk patients, aiming to refine current "one-size-fits-all" guidelines.

Methods: Totally 599 intermediate- and high-risk DTC patients from three centers were enrolled.

The Influence of Malnutrition-Sarcopenia Syndrome on Chorioretinal Microvasculature Using Optical Coherence Tomography Angiography.

Purpose: To probe into the effects of malnutrition-sarcopenia syndrome on the changes of retinal and choroidal microvasculature.

Methods: To achieve our goals, we employed optical coherence tomography angiography (OCTA), a cutting-edge non-invasive imaging technique, to compare retinal and choroidal parameters in a controlled setting. A total of 22 participants diagnosed with Malnutrition-Sarcopenia Syndrome were enrolled alongside 22 healthy subjects matched for age and gender as controls.

Synergistic regulation of different coordination shells of iron centers by sulfur and phosphorus enables efficient oxygen reduction in zinc-air batteries.

The modulation of the coordination environment of Fe-N active sites is crucial for enhancing the oxygen reduction catalytic activity of FeNC. However, comprehensively investigating the synergistic regulation of diverse coordination shells of Fe centers by various non-metallic heteroatoms poses a significant challenge. In this study, iron/sulfur/phosphorus/nitrogen-doped carbon nanotubes (FeNCSP) were synthesized through a two-step process that includes a solvothermal method followed by one-step calcination.

Applications of interpretable ensemble learning for workplace risk assessment: The Chinese coal industry as an example.

Machine learning has demonstrated potential in addressing complex nonlinear changes in risk assessment. However, further exploration is needed to enhance model interpretability and optimize performance. Therefore, this study aims to develop a novel workplace risk assessment framework.

Effect of add-on therapy with Traditional Chinese Medicine on the survival of patients with anemic lower-risk myelodysplastic syndromes in the real-world setting: a retrospective study.

Objective: To illustrate the effect of add-on therapy of Traditional Chinese Medicine (TCM) on the long-term survival of anemic lower-risk myelodysplastic syndromes (LR-MDS) patients.

Methods: In this study, we conducted a retrospective analysis of the data of patients with LR-MDS who were identified from Shuguang Hospital between January 2006 and June 2020. The Kaplan-Meier method was used to calculate overall survival (OS), while the Cox model was employed to analyze prognostic factors of long-term survival.

pH-/Viscosity-Activatable NIR Fluorescent Probes via Acceptor Engineering of Hemicyanine Dyes for High-Contrast Bioimaging.

Real-time monitoring of the lysosomal microenvironment using small-molecule probes is critical for understanding the complex interactions between organelles and diseases associated with lysosomal dysfunction. Most traditional fluorescent-dye-based lysosome probes rely on the protonation of the nitrogen atom in the morpholine unit to visualize the lysosomal microenvironment by inhibiting the photoinduced electron transfer (PET) effect. However, these probes often face selectivity issues within the complex cellular microenvironment.

Effects of exogenous insulin supplementation on lipid metabolism in peripartum obese dairy cows.

Cows with high body condition scores experience more severe negative energy balance (NEB) and undergo mobilization of more body fat during the peripartum period, leading to more production of nonesterified fatty acids (NEFA) and -hydroxybutyric acid (BHBA). Postpartum insulin secretion is lower, and insulin resistance is stronger in obese cows. Exogenous insulin supplementation has been hypothesized as a key approach for regulating NEFA in these cows.

1α,25(OH)2D3 Regulates the TGF-β1/Samd Signaling Pathway Inhibition of Hepatic Stellate Cell Activation.

To investigate the effect of 1α,25(OH)D on hepatic stellate cells and the mechanism of the TGF-β1/Smad signaling pathway.LX2 cells were treated with TGF-β1 and different concentrations of 1α,25(OH)D. Cell proliferation was assessed using the CCK8 assay to determine the optimal concentration of 1α,25(OH)D activity.

The swelling mechanism of ethylene-vinyl acetate polymer in different solvents molecular dynamics and experimental studies.

Ethylene-vinyl acetate (EVA) film is the predominant encapsulation material in crystalline silicon photovoltaic modules, the efficient and eco-friendly processing of which is essential for the recycling of the modules. Among the various existing techniques, the chemical approach uses solvents to induce swelling and dissolution on the EVA film to facilitate the separation of distinct layers. This method demonstrates the potential for achieving low-energy consumption and minimal-damage retrieval of the diverse materials within the components.

Mycobacterium leprae infection with rash misdiagnosed as a flare-up of systemic lupus erythematosus: a case report.

Background: Leprosy (Hansen's disease) is a curable, chronic contact infectious disease caused by Mycobacterium leprae. It mainly affects human skin and nerves and can cause progressive and permanent damage to the skin, nerves, limbs, eyes and is of great concern to the medical community.

Case Presentation: A 35-year-old Han Chinese female patient presented to our hospital with 11 years of recurrent erythema and pain in the limbs and face, which was aggravated by fever for 6 days.

Epigenetic Regulation of Anthocyanin Biosynthesis in 'Purple Rain'.

'Purple Rain' is characterized by its purple leaves and has ornamental applications. A green mutant line NL, which was mutated by line NZ of 'Purple Rain' during tissue culture, shows green leaves instead of the typical purple color of 'Purple Rain'. This study quantified the leaf color traits of NL and a normal 'Purple Rain' line NZ, and uncovered differentially expressed genes involved in flavonoid biosynthesis pathway genes in NL through RNA-Seq analysis.

LIC-CGAN: fast lithography latent images calculation method for large-area masks using deep learning.

Latent image calculation for large-area masks is an indispensable but time-consuming step in lithography simulation. This paper presents LIC-CGAN, a fast method for three-dimensional (3D) latent image calculation of large-area masks using deep learning. Initially, the library of mask clips and their corresponding latent images is established, which is then used to train conditional generative adversarial networks (CGANs).

Identifying functional cuproptosis-related long non-coding RNAs in patients with bladder cancer.

Background: Bladder cancer is the most common malignancy of the urinary tract and one of the most common cancers in the world. Cuproptosis is a novel type of cell death associated with tumorigenesis. In this study, we assessed the correlation between cuproptosis-related genes and tumorigenesis.

Preparation of transferrin-modified IR820-loaded liposomes and its effect on photodynamic therapy of breast cancer.

Objective: To prepare and characterize transferrin (Tf)-modified liposomes (Lipo) encapsulating the photosensitizing agent neoindocyanine green (IR820), and to investigate their effects on breast cancer 4T1 cells as well as in a breast cancer mouse model.

Methods: Photosensitive liposomes, IR820@Lipo and Tf-IR820@Lipo, were synthesized using thin film dispersion, with encapsulation efficiency assessed via UV detection. The physicochemical properties were analyzed using transmission electron microscopy (TEM) and particle size analysis.

Activatable Near-Infrared Fluorescence Probe for Hypochlorous Acid Detection in Early Diagnosis of Keloids.

Keloids represent pathologic conditions characterized by the presence of hyalinized collagen bundles and chronic inflammatory reactions. Recently, increased ROS production and disrupted apoptosis mechanisms in keloids have been reported, although the detailed mechanisms remain unclear. Herein, we developed a specific fluorescence probe, , to investigate ClO levels in keloids.

Application of Dynamic [F]FDG PET/CT Multiparametric Imaging Leads to an Improved Differentiation of Benign and Malignant Lung Lesions.

Purpose: To evaluate the potential of whole-body dynamic (WBD) 2-deoxy-2-[F]fluoro-D-glucose positron emission tomography/computed tomography ([F]FDG PET/CT) multiparametric imaging in the differential diagnosis between benign and malignant lung lesions.

Procedures: We retrospectively analyzed WBD PET/CT scans from patients with lung lesions performed between April 2020 and March 2023. Multiparametric images including standardized uptake value (SUV), metabolic rate (MR) and distribution volume (DV) were visually interpreted and compared.

Functionalized flattened bamboo board: In-situ immersion assembly of flame-retardant, waterproof and anti-mold composite coatings.

The flattened bamboo board (FB) represents a promising innovation in the bamboo industry. To address the challenges of flammability and hygroscopicity, composite coatings consisting of melamine (MEL), phytic acid (PA), cerium ions (Ce), and sodium laurate (La) are assembled on the FB surface through an in-situ impregnation strategy. The resulting MEL/PA-Ce@La FB exhibits exceptional flame retardancy.

Phytoremediation of metals in oil sands process affected water by native wetland species.

Process affected water and other industrial wastewaters are a major environmental concern. During oil sands mining, large amounts of oil sands process affected water (OSPW) are generated and stored in ponds until reclaimed and ready for surface water discharge. While much research has focused on organics in process waters, trace metals at high concentrations may also pose environmental risks.

Semi-supervised Double Deep Learning Temporal Risk Prediction (SeDDLeR) with Electronic Health Records.

Background: Risk prediction plays a crucial role in planning for prevention, monitoring, and treatment. Electronic Health Records (EHRs) offer an expansive repository of temporal medical data encompassing both risk factors and outcome indicators essential for effective risk prediction. However, challenges emerge due to the lack of readily available gold-standard outcomes and the complex effects of various risk factors.

Synergetic sludge conditioning by US enhanced Fe activated sodium persulfate: Physicochemical properties and mechanisms.

Efficient dewatering of sewage sludge is an energy- and carbon-saving procedure for sludge treatment in wastewater treatment facilities. The ultrasound-coupled divalent iron ion activated persulfate process can effectively promote sludge dewatering and improve organic substance content. Under the action of ultrasound (US 50 w/L), divalent iron ions (Fe) 200 mg/g (TS), and persulfate (PDS) 200 mg/g (TS) for 60 min, the capillary suction time (CST) was reduced by 79.

A novel robust hydrogel-assisted paper-based sensor based on fluorescence UiO-66-NH@ZIF-8 for the dual-channel detection of captopril.

Captopril (CP) is commonly used as an active enzyme inhibitor for the treatment of coronary heart disease, hypertension and angina pectoris. The development of sensitive and efficient method for CP analysis is of great importance in biomedical research. Herein, we fabricated a sensitive and robust hydrogel-assisted paper-based sensor based on fluorescence UiO-66-NH@ZIF-8 and Co, N-doped carbon nanozymes with oxidase-mimicking activity for accurate monitoring of captopril.