Bidirectional association between ADL disability and depressive symptoms among older adults: longitudinal evidence from CHARLS.

This study investigates the bidirectional relationship between Activities of Daily Living (ADL) disability and depressive symptoms (DS) among middle-aged and older adults in China, utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) from 2015 to 2018. A total of 8994 participants were analyzed to assess the impact of ADL on the risk of depressive symptoms, while 9673 participants were included to examine the influence of depressive symptoms on the risk of ADL disability. Cox proportional hazards regression models were employed to evaluate these relationships, adjusting for sociodemographic, lifestyle, and health-related covariates.

Cardiorespiratory fitness in Chinese children and adolescents: a systematic review and meta-analysis.

Background: Cardiorespiratory fitness (CRF) has become a significant focus in the field of public health. CRF is considered a strong predictor of health outcomes. However, cardiorespiratory fitness levels of children and adolescents are declining.

Dielectric metasurface-assisted terahertz sensing: mechanism, fabrication, and multiscenario applications.

Terahertz (THz) technology has attracted significant global interest, particularly in sensing applications, due to its nonionizing feature and sensitivity to weak interactions. Recently, owing to the advantages of low optical loss and the capability to support both electric and magnetic high-quality factor (high-Q) resonances, dielectric metasurfaces have emerged as a powerful platform for multiscenario terahertz sensing applications. This review summarizes recent advancements in dielectric metasurface-assisted THz sensing.

Photoinduced [3 + 2] Cycloadditions of Aryl Cyclopropyl Ketones with Alkynes and Alkenes.

The five-membered ring skeleton is one of the most pivotal in the area of pharmaceutical and natural products. [3 + 2] cycloadditions of cyclopropyl and unsaturated compounds are a highly efficient and atom-economical way to build a five-member compound. The previous works about the kind of [3 + 2] cycloadditions usually utilized metal or organic small molecule catalysts.

Association between enjoyment, physical activity, and physical literacy among college students: a mediation analysis.

Background: Physical literacy and enjoyment are important factors that affect physical activity.

Purpose: This work studies whether physical activity enjoyment (PAE) mediates the association between moderate to vigorous physical activity (MVPA) and physical literacy (PL) among college students.

Methods: Chinese college students were recruited using the Perceived Physical Literacy Instrument Scale (PPLI-SC), the International Physical Activity Questionnaire Short Form (IPAQ-SF), and the Physical Activity Enjoyment Scale.

Research on the Relationship between Physical Literacy, Physical Activity and Sedentary Behavior.

Unlabelled: During the COVID-19 pandemic, college students' health-related physical activity and physical literacy aroused widespread concern. This study evaluated the relationship among physical literacy (PL), sedentary behavior (SB), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA); we further explored whether LAP and SB mediated the association between PL and MVPA.

Methods: This study was based on a cross-sectional survey of Chinese college students.

Correction to Three Novel Alkaloids from Portulaca oleracea L. and Their Anti-inflammatory Effects.

Oleracimine and oleracimine A were isolated from Portulaca oleracea L. and described in the J. Agric.

Three Novel Alkaloids from Portulaca oleracea L. and Their Anti-inflammatory Effects.

Three novel carbon skeleton alkaloids, named oleracimine (1), oleracimine A (2), and oleracone A (3), with one novel azulene carbon skeleton compound, oleracone B (4), and one known compound, β-carboline (5), were first isolated from Portulaca oleracea L. The structures were determined using spectroscopic methods, including one- and two-dimensional nuclear magnetic resonance and high-resolution electrospray ionization time-of-flight mass spectrometry techniques. In addition, oleracimine (1) was used to investigate the anti-inflammatory effects on lipopolysaccharide-stimulated macrophages.

The anti-inflammation and pharmacokinetics of a novel alkaloid from Portulaca oleracea L.

Objectives: This study was to elucidate the pharmacokinetics of a novel alkaloid, 6-acetyl-2,2,5-trimethyl-2,3-dihydrocyclohepta[b]pyrrol-8(1H)-one, named oleracone isolated from Portulaca oleracea L., and to examine the anti-inflammatory ability with lipopolysaccharide (LPS) stimulated macrophages.

Methods: The novel alkaloid, oleracone, was isolated from Portulaca oleracea L.

Hepatic, gastric and intestinal first-pass effects of vitexin-2''-O-rhamnoside in rats by ultra-high-performance liquid chromatography.

Previous research in our laboratory found that the absolute bioavailability of vitexin-2''-O-rhamnoside (VR) was quite low at 4.89%. A rapid and sensitive UHPLC method using hesperidin as an internal standard was therefore developed and validated to investigate the reasons for this by determining VR in rat plasma after administering intravenously, intraportally (5 mg/kg), intraduodenally and intragastrically (40 mg/kg) to the rat model of the hepatic, gastric and intestinal first-pass effects.

Hepatic, gastric, and intestinal first-pass effects of vitexin in rats.

Context: Recent research has demonstrated that vitexin exhibits a prominent first-pass effect. In this light, it is necessary to investigate the causes of this distinct first-pass effect.

Objective: The aim of this study was to evaluate hepatic, gastric, and intestinal first-pass effects of vitexin in rats and, furthermore, to investigate the role of P-glycoprotein (P-gp) and cytochrome P450 3A (CYP3A) in the absorption and secretion of vitexin in the duodenum.

Hepatic and gastrointestinal first-pass effects of vitexin-4″-O-glucoside in rats.

Objectives: This paper was to clarify the reasons of low bioavailability of vitexin-4″-O-glucoside (VOG) in rats via hepatic combined with gastrointestinal first-pass effect.

Methods: Observed the hepatic first-pass effect through the comparison of area under the plasma concentration-time curve from zero to infinity (AUC0→∞ ) of VOG in arterial plasma after femoral and portal vein administration (10 mg/kg), similarly, evaluated the gastrointestinal first-pass effect after portal vein (10 mg/kg) and gastrointestinal administration (20 mg/kg). For the study on regulatory mechanisms of cytochrome P450 3A (CYP3A) and P-glycoprotein (P-gp) on the bioavailability of VOG, the solution of verapamil hydrochloride (60 mg/kg) was instilled into intestine at 10 min before the infusion of VOG.