Shift work effects on incident neuropsychiatric disorders and shift work tolerance.

Background: Shift work is associated with susceptibility to several neuropsychiatric disorders. This study aims to investigate the effect of shift work on the incidence of neuropsychiatric disorders, and highlighting how individual variability may influence the association.

Methods: UK Biobank participants with employment information were included.

Depression in Alzheimer's Disease: Epidemiology, Mechanisms, and Treatment.

Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past decades, a link between the 2 disease entities has received extensive acknowledgment, yet the complex nature of this relationship demands further clarification. Some evidence indicates that midlife depression may be an AD risk factor, while a chronic course of depression in late life may be a precursor to or symptom of dementia.

The relationship between self-esteem and aggressive behavior among Chinese adolescents: A moderated chain mediation model.

This study aimed to examine the relationship between adolescent self-esteem and aggressive behavior. Specifically, a moderated chain mediation model was developed to investigate the mediating role of jealousy and self-control and the moderating role of gender. Data were collected from 652 Chinese adolescents who completed the Self-Esteem Scale, Self-Report Jealousy Scale, Self-Control Scale and Aggressive Behavior Questionnaire.

Occupational characteristics and incident anxiety and depression: A prospective cohort study of 206,790 participants.

Background: This study aimed to analyze the impact of a wide spectrum of occupational characteristics on the incidence of anxiety and depression, and to determine the features affecting adaptation to specific characteristics.

Methods: Participants in paid employment or self-employed at baseline in UKB were included, with occupational characteristics extracted from O*NET. Cox-proportional-hazard models were conducted in the main analyses and subgroup analyses.

Identification of novel drug targets for the risk and prognosis of COVID-19.

Background: Since the epidemic continues, there is a pressing need to improve our understanding of coronavirus disease 2019 (COVID-19). Mendelian randomization (MR) studies provide us with a method to explore the causality between circulating proteins and COVID-19 susceptibility and severity. We aim to find new perspectives on the pathological mechanism of the disease and possible drug targets for treatment based on this study.

The roles of PAD2- and PAD4-mediated protein citrullination catalysis in cancers.

Peptidylarginine deiminases (PADs) catalyze the conversion of arginine residues to citrulline residues on target proteins in the presence of calcium ions. This elaborate type of posttranslational modification is termed citrullination. PADs may regulate gene transcriptional activity via histone citrullination.