Publications by authors named "Yihan Bao"
Article Synopsis
- A specific mutation in the OTOF gene is linked to severe hearing loss, which is studied using mutant mice that mimic this condition.
- Researchers used a base editor technique to correct the mutation in the inner ear of these mice, leading to significant restoration of hearing and otoferlin protein levels.
- The findings suggest that base editing could be a promising approach for treating hereditary deafness in humans.
Article Synopsis
- Micro-randomized trials focus on enhancing mobile health interventions like push notifications and often need to analyze causal effects using a method called inverse probability weighting (IPW).
- The challenge is that multiple treatments during the outcome period can inflate variance in estimates when using traditional IPW.
- To combat this, researchers propose two new estimators, "per-decision IPW" and a modified version based on semiparametric efficiency theory, which improve estimation accuracy for binary outcomes in micro-randomized trials.
Background: Drink Less is a behavior change app to help higher-risk drinkers in the United Kingdom reduce their alcohol consumption. The app includes a daily notification asking users to "Please complete your drinks and mood diary," yet we did not understand the causal effect of the notification on engagement nor how to improve this component of Drink Less. We developed a new bank of 30 new messages to increase users' reflective motivation to engage with Drink Less.
View Article and Find Full Text PDFPurpose: To examine associations between the topographic distribution of geographic atrophy (GA) and vision-related quality of life (VRQoL).
Methods: This study included 237 eyes from 161 participants in the Age-Related Eye Disease Study (AREDS). GA lesions were manually delineated with color fundus photographs obtained by the AREDS Research Group and atrophic area was measured in an Early Treatment Diabetic Retinopathy Study (ETDRS) grid.