Publications by authors named "Yih-Dar Shieh"
Therapeutic ultrasound (tUS) is widely used in chronic muscle pain control. However, its analgesic molecular mechanism is still not known. Our objective is to reveal the mechanism of the tUS-induced analgesia in mouse models of fibromyalgia.
View Article and Find Full Text PDFProlotherapy is widely used in pain control and tissue repair in pain medicine. The classical mode is injection with hypertonic dextrose in muscle or perimysium. However, the analgesic mechanism is still not known.
View Article and Find Full Text PDFBackground: Low-level laser therapy (LLLT) is widely used in pain control in the field of physical medicine and rehabilitation and is effective for fibromyalgia pain. However, its analgesic mechanism remains unknown. A possible mechanism for the effect of LLLT on fibromyalgia pain is via the antinociceptive signaling of substance P in muscle nociceptors, although the neuropeptide has been known as a neurotransmitter to facilitate pain signals in the spinal cord.
View Article and Find Full Text PDFArticle Synopsis
- Aromatic l-amino acid decarboxylase (AADC) is crucial for producing dopamine and serotonin, and its deficiency leads to developmental issues in children, particularly affecting motor skills.
- A study created a mouse model with an AADC gene mutation, resulting in significantly reduced AADC activity and severe dyskinesia, but some mice did survive to adulthood with compensatory adaptations.
- This new AADC deficient mouse model can aid in researching gene therapies for AADC deficiency and in developing treatments for related neurotransmitter disorders.