Agrimonolide Inhibits the Malignant Progression of Non-small Cell Lung Cancer and Induces Ferroptosis through the mTOR Signaling Pathway.

Background: Non-Small Cell Lung Cancer (NSCLC), a prevalent type of lung cancer, has a poor prognosis and contributes to a high mortality rate. Agrimonolide, which belongs to the Rosaceae family, possesses various biomedical activities. This study aimed to explore the efficacy and mechanism of agrimonolide in NSCLC.

Combined pre-conditioning with salidroside and hypoxia improves proliferation, migration and stress tolerance of adipose-derived stem cells.

Oxidative stress after ischaemia impairs the function of transplanted stem cells. Increasing evidence has suggested that either salidroside (SAL) or hypoxia regulates growth of stem cells. However, the role of SAL in regulating function of hypoxia-pre-conditioned stem cells remains elusive.

[The Establishment of Atrial Septal Defect Model in Pigs with Extracorporeal Circulation Followed by Patch Repairment].

Objective: To investigate the establishment of atrial septal defect model with high success rate in pigs with extracorporeal circulation and the method of followed patch repair.

Methods: Twenty Chinese miniature pigs weighing 45.3-55.

MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells.

Stem cell transplantation is one of most valuable methods in the treatment of myocardial infarction, and adipose-derived stem cells (ASCs) are becoming a hot topic in medical research. Previous studies have shown that ASCs can be differentiated into cardiomyocyte-like cells, but the efficiency and survival rates are low. We investigated the role and mechanism of microRNA-1 (miR-1) in the differentiation of ASCs into cardiomyocyte-like cells.

Single-stage surgery experience in a case of coarctation of the aorta with an arch aneurysm combined with severe coronary artery disease.

The best surgical approach for coarctation of the aorta (COA) combined with other cardiac diseases is uncertain. The simultaneous intracardiac repair of complex pathologies is desirable because multistage procedures may lead to a higher rate of mortality. We describe a case involving a 61-year-old woman who was suffering from COA with a concomitant arch aneurysm and coronary artery disease.

[Assessment of early mortality risk factors undergoing coronary artery bypass graft surgery].

Objective: To analyze early mortality risk factors and clinical characteristics in our patients undergoing coronary artery bypass graft (CABG) surgery.

Methods: Clinical data of 310 consecutive patients undergoing CABG from January 2005 to March 2007 were collected. Twenty-two risk factors were evaluated by univariate and multivariate Logistic stepwise regression analysis.

[The predictive values of EuroSCORE of early mortality in coronary artery bypass grafting patients].

Objective: To verify the predictive value of EuroSCORE of early mortality in coronary artery bypass grafting (CABG) patients.

Method: From January 2005 to March 2007, 310 consecutive patients were operated with CABG. Detailed data for the EuroSCORE risk factor were collected and all patients were scored according to the EuroSCORE additive model, retrospectively or prospectively.

Flow of power-law fluids in self-affine fracture channels.

The two-dimensional pressure driven flow of non-Newtonian power-law fluids in self-affine fracture channels at finite Reynolds number is calculated. The channels have constant mean aperture and two values zeta=0.5 and 0.