Publications by authors named "Yigit Unlu"
Bee products are an important source of nutrients and bioactive phytochemicals. This study aimed to determine the chemical composition (proximate composition, general phytochemical composition, sugar, and phenolic profiles) of four different products (honey, bee pollen, bee bread, and propolis), obtained from the same apiary, as well as to assess their biological activity through antioxidant and enzyme inhibition assays (α-amylase, α-glucosidase, lipase, AchE, neuraminidase, angiotensin-converting enzyme, urease, trypsin, tyrosinase, carbonic anhydrase, thioredoxin reductase, adenosine deaminase). Clear differences were observed among the samples in terms of both chemical composition and biological activity.
View Article and Find Full Text PDFBackground: Measures of energy metabolism (energy expenditure [EE], respiratory exchange ratio [RER]) have been associated with ad libitum energy intake (EI) and weight gain in previous observational studies, suggesting that energy-sensing mechanisms drive EI to meet metabolic energy demands.
Objectives: We aimed to employ mild cold exposure as an intervention to alter energy metabolism and evaluate its causal effects on concurrent and next day ad libitum EI.
Methods: In a controlled crossover study, 47 volunteers (16 female; age 37.
Objective: We investigated how changes in 24-h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake.
Methods: Forty-four healthy, weight-stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.
Article Synopsis
- The study explored how differences in gut hormone levels affect metabolic flexibility in response to diet changes among 69 healthy volunteers.
- During a 24-hour assessment, participants' metabolic responses to various diets (normal, high-fat, and high-carb) were monitored, revealing significant shifts in energy oxidation based on the type of diet consumed.
- Notably, higher levels of the gut hormone GLP-1 during high-carbohydrate overfeeding were linked to increased carbohydrate oxidation and may play a crucial role in managing metabolic flexibility when consuming high-carb foods.
Article Synopsis
- Short-term fasting leads to an 8% decrease in 24-hour energy expenditure (24hEE), suggesting a thrifty phenotype characterized by energy conservation.
- Researchers studied the roles of ghrelin, growth hormone (GH), and insulin-like growth factor 1 (IGF-1) in energy metabolism during fasting in 47 healthy individuals.
- Results showed that while GH increased significantly during fasting, ghrelin levels varied among participants and were linked to the extent of the decrease in 24hEE, indicating ghrelin might serve as a biomarker for energy efficiency in individuals with a thrifty phenotype.
In this study, we applied a second round of random mutagenesis using ethyl methanesulfonate to further increase the lipid productivity of a Chlorella vulgaris mutant strain. We generated a mutant (UV715-EMS25) with a lipid content and biomass that were respectively 67% and 35% higher than those of the wild type (WT). The highest achieved lipid productivity in UV715-EMS25 was 91 mg L day.
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