NERD-dependent mA modification of the nascent FLC transcript regulates flowering time in Arabidopsis.

N-methyladenosine (mA) is the most prevalent internal modification on messenger RNA. Although recent studies have shown mA effects on determining the fate of mRNA through modulating various aspects of plant mRNA metabolism, whether and how mA affects gene transcription in plants remains elusive. Here we show that NEEDED FOR RDR2-INDEPENDENT DNA METHYLATION (NERD), a plant-specific protein, is an essential component of the mA methyltransferase complex required for regulating the transcription of a central floral repressor FLOWERING LOCUS C (FLC) in Arabidopsis.

A comprehensive metabolomic and lipidomic study of olanzapine in the treatment of first-episode schizophrenia.

Background: Despite advances in research, critical gaps remain in understanding the molecular mechanisms of antipsychotic medications such as olanzapine. This study investigated the molecular pathways by which olanzapine exerts its therapeutic effects and causes metabolic side effects by analyzing changes in the serum metabolic and lipid profiles of patients with first-episode schizophrenia.

Methods: Clinical symptoms were assessed using the Positive and Negative Symptom Scale (PANSS) in 43 patients with first-episode schizophrenia.

Care Tasks and Caregiver Burden Among Family Caregivers of Patients With Mental Disorders in China: Illness Perception as a Mediator and Social Support as a Moderator.

Introduction: Caring for a family member with mental disorders is burdensome, which may not only damage the caregivers' well-being and health, but also hinder patients' recovery. It is critical to investigate the underlying mechanisms for caregiver burden.

Aim: To examine the mediating effect of illness perception and the moderating function of social support on the association between care tasks and caregiver burden.

The independent and joint relationships between dietary antioxidant intake with risk of chronic obstructive pulmonary disease and all-cause mortality: insights from NHANES.

Background: Numerous studies have indicated that a diet rich in antioxidants can prevent Chronic Obstructive Pulmonary Disease (COPD). However, the relationship between combined dietary antioxidant intake and the risk of COPD remains unclear. The Comprehensive Dietary Antioxidant Index (CDAI) is a composite score of various dietary antioxidants, including vitamins A, C, E, zinc, selenium, and carotenoids.

Combined Bulked Segregant Analysis-Sequencing and Transcriptome Analysis to Identify Candidate Genes Associated with Cold Stress in L.

Cold tolerance in rapeseed is closely related to its growth, yield, and geographical distribution. However, the mechanisms underlying cold resistance in rapeseed remain unclear. This study aimed to explore cold resistance genes and provide new insights into the molecular mechanisms of cold resistance in rapeseed.

Association between dietary intake of live microbes and chronic obstructive pulmonary disease: a cross-sectional study of NHANES 2007-2012.

Background: Diet plays a crucial role in intervening in the development of chronic obstructive pulmonary disease (COPD), yet previous studies have not investigated the impact of dietary intake of live microbes on COPD. This study aims to assess the relationship between the two.

Methods: Participants from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2012 were selected.

The prevalence and profiles of adverse childhood experiences and their associations with adult mental health outcomes in China: a cross-sectional study.

Background: Adverse childhood experiences (ACEs) are common and associated with mental disorders. However, the prevalence and co-occurrence of ACEs and their association with mental health outcomes among Chinese adults have not been well demonstrated.

Methods: China Mental Health Survey, a cross-sectional nationally representative survey consisting of 28,140 adults, was conducted from July 2013 to March 2015.

The Voltage-Gated Potassium Channel (K4) Contributes to Active Hearing in .

The full complement of ion channels which influence insect auditory mechanotransduction and the mechanisms by which their influence is exerted remain unclear. (K4), a family member encoding voltage-gated potassium channels in , has been shown to localize to dendrites in some neuron types, suggesting the potential role of in hearing, including mechanotransduction. A GFP trap was used to visualize the localization of the channel in Johnston's organ neurons responsible for hearing in the antenna.

Association between advanced lung cancer inflammation index and osteoporosis in patients with type 2 diabetes mellitus: evidence from NHANES.

Background: Previous studies have shown a significantly increased prevalence of osteoporosis (OP) in patients with type 2 diabetes mellitus (T2DM), which is closely associated with inflammation and nutrition. This study aimed to investigate the relationship between the advanced lung cancer inflammation index (ALI) and OP in patients with T2DM.

Methods: This cross-sectional analysis was conducted based on data from middle-aged and older adults aged 50 years and older with T2DM from the National Health and Nutrition Examination Survey (NHANES).

A Novel System for Fabricating Microspheres with Microelectromechanical System-Based Bioprinting Technology.

The microspheres were widely utilized in the field of life sciences, and we have developed an innovative microelectromechanical system (MEMS)-based bioprinting technology (MBT) system for the preparation of the microspheres. The microspheres can be automatically and high-throughput produced with this cutting-edge system. This paper mainly introduced a novel, efficient, and cost-effective approach for the microsphere fabrication with the MBT system.

Caregiving burden, depression, and anxiety in informal caregivers of people with mental illness in China: a cross-sectional survey.

Background: Caregiving for people with mental illness (PwMI) could be burdensome, especially for informal caregivers. However, there is a scarcity of research investigating caregiving burden among informal caregivers of PwMI in China at the national level. To fill this gap, this study examined the prevalence of caregiving burden, depression, and anxiety, as well as their associated factors, among a cross-sectional sample of informal caregivers of PwMI in China.

In-sewer iron dosing enhances bioenergy recovery in downstream sewage sludge anaerobic digestion: The impact of iron salt types and thermal hydrolysis pretreatment.

Dosing iron salts is a widely adopted strategy for sewer odor and corrosion management, and it can affect bioenergy recovery during anaerobic digestion (AD) of sludge in downstream wastewater treatment plants. However, the different impacts of in-sewer iron salt dosing on AD, depending on the types of iron and digestion conditions, remain unclear. Therefore, this study investigated the impact of in-sewer ferrous (Fe(II)) and ferrate (Fe(VI)) dosing on bioenergy recovery in both conventional AD and AD with thermal hydrolysis pretreatment (THP).

Identification of the Biomarkers for Chronic Gastritis with TCM Damp Phlegm Pattern by Using Tongue Coating Metabolomics.

Objective: This study aimed to establish a model for identifying chronic gastritis with the traditional Chinese medicine damp phlegm pattern by examining metabolite changes in the tongue coating of patients. It also explored the role of metabolic pathways in the pathogenesis of this condition.

Methods: This cross-sectional study involved 300 patients diagnosed with chronic gastritis.

Genetical effects of sleep traits on postpartum depression: a bidirectional two-sample Mendelian randomization study.

Background: Postpartum depression (PPD) is widely recognized as the most prevalent mental health crisis following childbirth and has been linked to sleep disturbances. However, the potential causal relationships between various sleep traits and PPD remain unclear. This study employs a bidirectional two-sample Mendelian randomization (MR) approach to investigate these associations.

Sugar transporter modulates nitrogen-determined tillering and yield formation in rice.

Nitrogen (N) fertilizer application ensures crop production and food security worldwide. N-controlled boosting of shoot branching that is also referred as tillering can improve planting density for increasing grain yield of cereals. Here, we report that Sugar Transporter Protein 28 (OsSTP28) as a key regulator of N-responsive tillering and yield formation in rice.

A portable optical sensor combining smartphone with phycocyanin-based fluorescent test paper for rapid, visual and on-site detection of CO.

With the development of global industry, carbon dioxide emissions surged. The conversion of carbon dioxide from the air results in some CO, which can exacerbate environmental disasters like ocean acidification. Therefore, the content of CO in seawater is an important indicator of the degree of ocean acidification.

Identification of novel proteins in inflammatory bowel disease based on the gut-brain axis: a multi-omics integrated analysis.

Background: The gut-brain axis has garnered increasing attention, with observational studies suggesting its involvement in the disease activity and progression of inflammatory bowel disease (IBD), but the precise mechanisms remain unclear.

Materials And Methods: In this study, we aimed to investigate "novel proteins" underlying IBD in the brain using a comprehensive multi-omics analysis approach. We performed integrated analyses of proteomics and transcriptomics in the human prefrontal cortex (PFC) tissue, coupled with genome-wide association studies (GWAS) of IBD, crohn's disease (CD), and ulcerative colitis (UC).

Perfluorooctanoic acid effect and microbial mechanism to methane production in anaerobic digestion.

Perfluorooctanoic acid (PFOA) as emerging pollutants was largely produced and stable in nature environment. Its fate and effect to the wasted sludge digestion process and corresponding microbial mechanism was rarely reported. This study investigated the different dose of PFOA to the wasted sludge digestion process, where the methane yield and microbial mechanism was illustrated.

The correlation between frailty index and incidence, mortality in obstructive sleep apnea: Evidence from NHANES.

Background: The emergence of obstructive sleep apnea (OSA) is marked by a growing trend towards younger individuals, while its developmental trajectory remains shrouded in uncertainty, accompanied by intricate prognostic implications. While frailty and sleep problems often coexist, the relationship between them remains unclear. Hence, this study aims to utilize the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2008 to analyze and explore the relationship between the level of frailty index (FI) and the risk of OSA incidence and survival outcomes.

Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort.

Introduction: Symptoms during the onset of major depressive disorder [MDD] and bipolar disorder type II [BD-II] are similar. The difference of hippocampus subregion could be a biological marker to distinguish MDD from BD-II.

Methods: We recruited 61 drug-naïve patients with a first-episode MDD and BD-II episode and 30 healthy controls (HC) to participate in a magnetic resonance imaging [MRI] study.