Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males.

Stress is an established risk factor for negative health outcomes. Salivary cortisol and testosterone concentrations increase in response to acute psychosocial stress. It's crucial to reduce stress for health and well-being through evidence-based interventions.

Macrophage depletion with clodronate-containing liposomes affects the incidence and development of rheumatoid arthritis.

Objective: This study investigated the effect of macrophage depletion with clodronate-containing liposomes (Clo-lip) on the incidence and development of rheumatoid arthritis (RA).

Methods: The effect of macrophage depletion with Clo-lip in the spleen was assessed by HE (haematoxylin and eosin) staining and immunohistochemistry (IHC). Thirty BALB/c mice were randomly divided into three groups, which were administered PBS-lip, Clo-lip, or normal saline.

Clinical Effects of CpG-Based Treatment on the Efficacy of Hepatocellular Carcinoma by Skewing Polarization Toward M1 Macrophage from M2.

Objective: This study aims to explore the clinical efficacy of CpG-based therapy for treating hepatocellular carcinoma (HCC) by skewing polarization toward M1 macrophage from M2.

Methods: Pulmonary metastasis rate, overall survival time, and remission rate of 10 patients with HCC treated with transcatheter arterial chemoembolization (TACE) combined with CpG therapy and 10 age-, gender-, and TNM-matched patients treated with TACE (control group) were compared.

Results: No pulmonary metastasis rate was 70% in the combined treatment group and 40% in the control group, respectively; and the differences between the two groups were statistically significant (p < 0.

Inhibition of tribbles protein-1 attenuates radioresistance in human glioma cells.

Radiotherapy is one of the remedies in the treatment of glioma. The radioresistance is a major drawback, of which the mechanism is unclear. Tribble protein and histone deacetylase are involved in the cancer pathogenesis.

Neovibsanin B inhibits human malignant brain tumor cell line proliferation and induces apoptosis.

The present study was designed to examine the effect of neovibsanin B on glioma cell viability, apoptosis and on the survival time in mice bearing tumor xenografts. The results demonstrated that neovibsanin B significantly reduced the cell viability of GL261-NS and GL261-AC cells in a dose-dependent manner. However the inhibition of proliferation was more significant in GL261-NS cells.

Specific cellular immune response elicited by the necrotic tumor cell-stimulated macrophages.

Objective: To determine whether the necrotic tumor cell-stimulated macrophages (NTCSM) could elicit specific immune response.

Methods: Mice were immunized with the necrotic H22 tumor cell lysate-stimulated macrophages and the specific immune responses against the same tumor challenge were examined. The morphologic characteristics were observed with the transmission electron microscope and scanning electron microscopy.

Application of attention network test and demographic information to detect mild cognitive impairment via combining feature selection with support vector machine.

Mild cognitive impairment (MCI) is now thought as the prodromal phase of Alzheimer's disease (AD), and the usual method for diagnosing the disease would be a battery of neuropsychological assessment. The present study proposes to integrate a feature selection scheme with support vector machine (SVM) to identify patients with MCI by using attention network test (ANT) and demographic data. Forty-two patients with MCI and forty-five normal individuals underwent ANT recording, and the reaction time and accuracy of ANT and demographics (age, gender, and educational level) were selected as original features.

[Oral glucose tolerance and insulin release test in 52 cases of obese and overweight children].

Objective: To assess the state of glucose metabolism and beta-cell function in obese and overweight children.

Methods: Levels of glucose and insulin were detected during oral glucose tolerance test in 52 obese and overweight children aged 11.3 +/- 1.

[Prader-Willi syndrome and genomic imprinting].

Objective: Prader-Willi syndrome (PWS) is an example of a human genetic disorder that involves imprinting genes on the proximal long arm of chromosome 15 and SNRPN gene as a candidate gene for this syndrome. The purpose of this study was to show the molecular genetic defects and genomic imprinting basis in Chinese PWS patients and to evaluate the clinical applications of a differential diagnostic test for PWS.

Methods: Fluorescence in situ hybridization (FISH) and methylation-specific PCR (MSPCR) techniques were applied for 4 clinically suspected PWS patients.