Fingolimod alleviates type 2 diabetes associated cognitive decline by regulating autophagy and neuronal apoptosis via AMPK/mTOR pathway.

This study aimed to reveal the role of fingolimod (FTY720) in mice with type 2 diabetes-associated cognitive decline and explore its potential neuroprotective mechanism. Mice were divided into five groups: normal control, normal control + FTY720 (1.0 mg/kg/day), type 2 diabetes mellitus, type 2 diabetes mellitus + low-dose FTY720 (0.

Horizontal plasmid transfer promotes antibiotic resistance in selected bacteria in Chinese frog farms.

The emergence and dissemination of antibiotic resistance genes (ARGs) in the ecosystem are global public health concerns. One Health emphasizes the interconnectivity between different habitats and seeks to optimize animal, human, and environmental health. However, information on the dissemination of antibiotic resistance genes (ARGs) within complex microbiomes in natural habitats is scarce.

Visual Strain Sensors Based on Fabry-Perot Structures for Structural Integrity Monitoring.

Strain sensors that can rapidly and efficiently detect strain distribution and magnitude are crucial for structural health monitoring and human-computer interactions. However, traditional electrical and optical strain sensors make access to structural health information challenging because data conversion is required, and they have intricate, delicate designs. Drawing inspiration from the moisture-responsive coloration of beetle wing sheaths, we propose using Ecoflex as a flexible substrate.

Dormant bacterial spores encrypt a long-lasting transcriptional program to be executed during revival.

Sporulating bacteria can retreat into long-lasting dormant spores that preserve the capacity to germinate when propitious. However, how the revival transcriptional program is memorized for years remains elusive. We revealed that in dormant spores, core RNA polymerase (RNAP) resides in a central chromosomal domain, where it remains bound to a subset of intergenic promoter regions.

glycosides sensitizes cisplatin chemotherapeutic potency by modulating gut microbiota in epithelial ovarian cancer.

Epithelial ovarian cancer (EOC) is a fatal gynecological malignancy with limited therapeutic options. Previous research has demonstrated that glycosides (GTW) can enhance effectiveness of cisplatin (DDP) chemotherapy against EOC. However, the underlying mechanism of GTW alleviating EOC still remains unclear.

Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.

Cisplatin resistance is the main cause of postoperative recurrence and difficulty in the treatment of ovarian cancer. It is urgently needed to identify therapeutic drugs with unique functions to overcome the current challenges in the treatment of ovarian cancer. In this study, we found that TG promoted the accumulation of ROS and MDA in A2780/DDP cells and downregulated the expression of key antioxidant molecules.

Eu-Doped (Gd, La)AlO Perovskite Single Crystals: Growth and Red-Emitting Luminescence.

Eu-doped GdAlO (Eu:GAP) and GdLaAlO (Eu:GLAP) perovskite single crystals were successfully grown using the optical floating zone (OFZ) method. The microstructure, optical, photoluminescence (PL) and radioluminescence (under X-ray excitation, XEL) were investigated. Under the PL excitation of 275 nm, obvious emission bands peaking at 556 nm, 592 nm, 617 nm, 625 nm, 655 nm, and 706 nm were demonstrated, which correspond to the 5D → 7F (j = 0-4) transitions of Eu.

Ce, Pr Co-Doped LuAlO Single Crystals and Ceramics: A Comparative Study.

Ce, Pr co-doped LuAlO (Ce, Pr:LuAG) single crystals and ceramics were prepared using the optical floating zone (OFZ) and reactive vacuum sintering methods, respectively. The microstructure, photo- (λ = 450 nm), and radio-luminescence (under X-ray excitation) performance, as well as scintillation light yield (LY, under γ-ray, Cs source) of both materials, were investigated and compared. Ce, Pr:LuAG ceramics had an in-line transmittance of approximately 20% in the visible light range, while the analogous crystals were more transparent (~65%).

Colossal Nernst power factor in topological semimetal NbSb.

Today solid-state cooling technologies below liquid nitrogen boiling temperature (77 K), crucial to quantum information technology and probing quantum state of matter, are greatly limited due to the lack of good thermoelectric and/or thermomagnetic materials. Here, we report the discovery of colossal Nernst power factor of 3800 × 10W m K under 5 T at 25 K and high Nernst figure-of-merit of 71 × 10K under 5 T at 20 K in topological semimetal NbSb single crystals. The observed high thermomagnetic performance is attributed to large Nernst thermopower and longitudinal electrical conductivity, and relatively low transverse thermal conductivity.

High-Throughput Screening for Thermoelectric Semiconductors with Desired Conduction Types by Energy Positions of Band Edges.

The conduction type of semiconductors is vitally important in many fields (e.g., photovoltaics, transistors, and thermoelectrics), but so far, there is no effective and simple indicator to quickly judge or predict the conduction type of various semiconductors.

Antibiotic Therapy and Vaginal Microbiota Transplantation Reduce Endometriosis Disease Progression in Female Mice NF-κB Signaling Pathway.

Endometriosis (EMS) is a disease characterized by estrogen-dependent, chronic inflammatory, and annoying symptoms, which inflicts about 10% reproductive-age women. The diagnosis of endometriosis mainly depends on pathological examination after surgical resection while the pathogenesis of EMS is not clear enough. Surgical resection and drug therapy (including painkillers and hormone therapy, especially gonadotropin-releasing hormone analogs, GnRH-a) are widely used, but they are expensive and have many side effects.

Wide Concentration Range of Tb Doping Influence on Scintillation Properties of (Ce, Tb, Gd)GaAlO Crystals Grown by the Optical Floating Zone Method.

To obtain a deeper understand of the energy transfer mechanism between Ce and Tb ions in the aluminum garnet hosts, (Ce, Tb, Gd)GaAlO (GGAG:Ce, Tb) single crystals grown by the optical floating zone (OFZ) method were investigated systematically in a wide range of Tb doping concentration (1-66 at.%). Among those, crystal with 7 at.

Revealing the Disturbed Vaginal Micobiota Caused by Cervical Cancer Using High-Throughput Sequencing Technology.

Cervical cancer is the fourth most prevalent cancer type among all malignancies, so it is of great significance to find its actual pathogenesis mechanisms. In the present study, 90 women were enrolled, and high-throughput sequencing technology was firstly used to analyze the vaginal microbiota of healthy women (C group), cervical intraepithelial neoplasia patients (CIN group) and cervical cancer patients (CER group). Our results indicates that compared with C group, a higher HPV infection rate as well as increased Neutrophil ratio and tumor marker squamous cell carcinoma antigen (SCCA) were obtained, and a decrease in Lymphocyte ratio and Hemoglobin were also present.

Ternary Compounds CuTe ( = Y, Sm, and Dy): A Family of New Thermoelectric Materials with Trigonal Structures.

In this work, we report a series of CuTe ( = Y, Sm, and Dy) ternary compounds with a trigonal structure (3̅) as a family of new thermoelectric materials. First-principles calculations show that CuTe ( = Y, Sm, and Dy) compounds are semiconductors with similar band structures and moderate band gaps (0.69-0.

Characterization of Five Isolates Co-expressing ESBL and MCR-1 Resistance Mechanisms From Different Origins in China.

Present study characterized five co-expressing ESBL and MCR-1 recovered from food, food-producing animals, and companion animals in China. Antimicrobial susceptibility tests, conjugation experiments, and plasmid typing were performed. Whole genome sequencing (WGS) was undertaken for all five isolates using either PacBio RS II or Illumina HiSeq 2500 platforms.