Effects of Exercises of Different Intensities on Bone Microstructure and Cardiovascular Risk Factors in Ovariectomized Mice.

Postmenopausal women face increased risks of osteoporosis and cardiovascular diseases due to estrogen decline. This study investigated the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on bone microstructure and cardiovascular risk factors in ovariectomized (OVX) mice. Results showed that both exercise regimens improved blood lipid profiles and vascular structure, reducing systolic blood pressure (-11.

Reconstruction of porous media pore structure and simulation effect analysis of multi-index based on SNESIM algorithm.

The pore structure of porous media directly affects its permeability characteristics and fluid flow properties, making the accurate reconstruction of these structures of great significance. In recent years, multi-point statistics (MPS) methods have been widely used in pore structure modeling. Among them, the SNESIM algorithm, as an advanced MPS technique, has been extensively applied in the study of porous media pore structures.

High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.

Background: The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity of noise that impair health is crucial for developing effective interventions. The study aimed to determine the acute noise intensity thresholds that elicit anxiety-like behaviors and brain damage in female rats, and then to elucidate the underlying neurobiological mechanisms.

Elevating Postinjection Stability in Silk Nanofibril Hydrogels to Prevent Intervertebral Disc Degeneration.

Injectable hydrogels offer a minimally invasive approach to treating intervertebral disc degeneration, a prevalent condition that affects 90% of individuals and often leads to significant pain and disability. Despite being a critical yet often overlooked issue that could lead to suboptimal therapeutic outcomes, the mechanical integrity of these gels frequently diminishes postinjection due to the injection process itself. To address this challenge, our research developed a silk-nanofibril-based hydrogel enhanced through simple polymerization of dopamine.

A dataset of venture capitalist types in China (1978-2021): A machine-human hybrid approach.

Despite escalating interest in distinguishing among various types of venture capitalists (VCs) and their roles in shaping entrepreneurship and innovation, such research remains sparse in the world's second-largest VC market, i.e., China.

Comprehensive retrospect and future perspective on bacteriophage and cancer.

Background: Researchers gradually focus on the relationship between phage and cancer.

Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer.

Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023.

Annual emissions of NO, NO, HONO, and NH from maize-wheat fields in the North China Plain.

Fertilized agricultural soil is a significant source of gaseous nitrogen compounds (GNCs), including NO, NO, HONO, and NH. The North China Plain (NCP) is the "hot region" for the release of these GNCs due to intensive fertilization practices. However, existing research has primarily focused on NO emissions from fertilized farmland in the NCP, lacking comprehensive observational studies on other GNCs.

Gut microbial subtypes and clinicopathological value for colorectal cancer.

Background: Gut bacteria are related to colorectal cancer (CRC) and its clinicopathologic characteristics.

Objective: To develop gut bacterial subtypes and explore potential microbial targets for CRC.

Methods: Stool samples from 914 volunteers (376 CRCs, 363 advanced adenomas, and 175 normal controls) were included for 16S rRNA sequencing.

Trace elements in pancreatic cancer.

Background: Pancreatic cancer (PCA) is an extremely aggressive malignant cancer with an increasing incidence and a low five-year survival rate. The main reason for this high mortality is that most patients are diagnosed with PCA at an advanced stage, missing early treatment options and opportunities. As important nutrients of the human body, trace elements play an important role in maintaining normal physiological functions.

Advances in bacteria-based drug delivery systems for anti-tumor therapy.

In recent years, bacteria have gained considerable attention as a promising drug carrier that is critical in improving the effectiveness and reducing the side effects of anti-tumor drugs. Drug carriers can be utilised in various forms, including magnetotactic bacteria, bacterial biohybrids, minicells, bacterial ghosts and bacterial spores. Additionally, functionalised and engineered bacteria obtained through gene engineering and surface modification could provide enhanced capabilities for drug delivery.

Migration Activity of (Lepidoptera: Noctuidae) between China and the South-Southeast Asian Region.

The common cutworm, (F.), feeds on a wide variety of food and cash crops and is one of the most widespread and destructive agricultural pests worldwide. Migration is the biological basis of its regional population outbreaks but the seasonal movement of this pest between east and south Asia regions remains unknown.

Third-generation PacBio sequencing to explore gut bacteria and gender in colorectal cancer.

Background: Gut bacteria have an important influence on colorectal cancer (CRC). The differences of gut bacteria between genders have been the hot spots.

Objective: To analyze the relationship between gut bacteria and gender differences in patients with CRC.

Reducing Soil-Emitted Nitrous Acid as a Feasible Strategy for Tackling Ozone Pollution.

Severe ozone (O) pollution has been a major air quality issue and affects environmental sustainability in China. Conventional mitigation strategies focusing on reducing volatile organic compounds and nitrogen oxides (NO) remain complex and challenging. Here, through field flux measurements and laboratory simulations, we observe substantial nitrous acid (HONO) emissions () enhanced by nitrogen fertilizer application at an agricultural site.

Advances in single-cell sequencing technology in microbiome research.

With the rapid development of histological techniques and the widespread application of single-cell sequencing in eukaryotes, researchers desire to explore individual microbial genotypes and functional expression, which deepens our understanding of microorganisms. In this review, the history of the development of microbial detection technologies was revealed and the difficulties in the application of single-cell sequencing in microorganisms were dissected as well. Moreover, the characteristics of the currently emerging microbial single-cell sequencing (Microbe-seq) technology were summarized, and the prospects of the application of Microbe-seq in microorganisms were distilled based on the current development status.

Advances in reprogramming of energy metabolism in tumor T cells.

Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial factor, energy metabolism influences the activation, proliferation, and function of T cells, and thus metabolic reprogramming of T cells is a unique research perspective in cancer immunology. Special conditions within the tumor microenvironment and high-energy demands lead to alterations in the energy metabolism of T cells.

Identification of enterotype and its predictive value for patients with colorectal cancer.

Background: Gut microbiota dysbiosis involved in the pathogenesis of colorectal cancer (CRC). The characteristics of enterotypes in CRC development have not been determined.

Objective: To characterize the gut microbiota of healthy, adenoma, and CRC subjects based on enterotype.

Characteristics and sources of peroxyacetyl nitrate (PAN) in the rural North China Plain: Results from 1-year continuous observations.

Peroxyacetyl nitrate (PAN) is an important photochemical pollutant in the troposphere, whereas long-term measurements are scarce in rural areas in North China Plain (NCP), resulting in unclear seasonal variations and sources of PAN in rural NCP. In this study, we conducted a 1-year observation of PAN during 2021-2022 at the rural NCP site. The average concentrations of PAN were 1.

GPX3 is a key cholesterol-related gene associated with prognosis and tumor-infiltrating T cells in colorectal cancer.

High cholesterol is an important factor inducing colorectal cancer (CRC). The study aims to determine the key genes and regulatory mechanism associated with tumor-infiltrating T cells underlying cholesterol-induced CRC. Gene expression data and clinical data from CRCS in The Cancer Genome Atlas (TCGA) were selected for differential expression and survival analysis.

Mitochondria: one of the vital hubs for molecular hydrogen's biological functions.

As a novel antioxidant, a growing body of studies has documented the diverse biological effects of molecular hydrogen (H) in a wide range of organisms, spanning animals, plants, and microorganisms. Although several possible mechanisms have been proposed, they cannot fully explain the extensive biological effects of H. Mitochondria, known for ATP production, also play crucial roles in diverse cellular functions, including Ca signaling, regulation of reactive oxygen species (ROS) generation, apoptosis, proliferation, and lipid transport, while their dysfunction is implicated in a broad spectrum of diseases, including cardiovascular disorders, neurodegenerative conditions, metabolic disorders, and cancer.

Correlation of gut microbiota with leukopenia after chemotherapy in patients with colorectal cancer.

Background: The most common toxic side effect after chemotherapy, one of the main treatments for colorectal cancer (CRC), is myelosuppression.

Objective: To analyze the correlation between gut microbiota and leukopenia after chemotherapy in CRC patients.

Methods: Stool samples were collected from 56 healthy individuals and 55 CRC patients.

Single-cell transcriptome analysis reveals T population heterogeneity and functions in tumor microenvironment of colorectal cancer metastases.

Cell mediated immune escape, a microenvironment factor, induces tumorigenesis and metastasis. The purpose of this study was to display the characteristics of T cell populations in immune microenvironments for colorectal cancer (CRC) metastasis. Unsupervised cluster analysis was conducted to identify functionally distinct T cell clusters from 3,003 cells in peripheral blood and 4,656 cells in tissues.

Significantly mitigating PM pollution level via reduction of NO emission during wintertime.

Despite considerable decreases in fine particulate matter (PM) in Chinese megacities over the past decade, many second- and third-tier cities that distribute abundant industrial enterprises are still facing great challenges for PM further reduction under the recent policy background of eliminating heavily-polluted weather. In view of core effects of NO on PM, the deeper reductions of NO in these cities are expected to break the plateau of PM decline, however, the link between NO emission and PM mass loading is currently lacking. Herein, we progressively construct an evaluation system for PM productions based on daily NO emissions in a typical industrial city (Jiyuan), considering a sequence of nested parameters involving evolutions of NO into nitric acid and then nitrate, and contributions of nitrate to PM.

Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice.

Aims: As the ovaries age and women transition to menopause and postmenopause, reduced estradiol levels are associated with anxiety and depression. Exercise contributes to alleviate anxiety and depression and the bone-derived hormone osteocalcin has been reported to be necessary to prevent anxiety-like behaviors. The aim of this study was to investigate the effects of exercise on anxiety behaviors in climacteric mice and whether it was related to osteocalcin.

FeNiCrCoMn High-Entropy Alloy Nanoparticles Loaded on Carbon Nanotubes as Bifunctional Oxygen Catalysts for Rechargeable Zinc-Air Batteries.

An efficient and stable bifunctional oxygen catalyst is necessary to complete the application of the rechargeable zinc-air battery. Herein, an economical and convenient process was adopted to successfully coat high-entropy alloy FeNiCrCoMn nanoparticles on carbon nanotubes (CNTs). In 0.