Postmenopausal women face increased risks of osteoporosis and cardiovascular diseases due to estrogen decline. This study investigated the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on bone microstructure and cardiovascular risk factors in ovariectomized (OVX) mice. Results showed that both exercise regimens improved blood lipid profiles and vascular structure, reducing systolic blood pressure (-11.
View Article and Find Full Text PDFThe pore structure of porous media directly affects its permeability characteristics and fluid flow properties, making the accurate reconstruction of these structures of great significance. In recent years, multi-point statistics (MPS) methods have been widely used in pore structure modeling. Among them, the SNESIM algorithm, as an advanced MPS technique, has been extensively applied in the study of porous media pore structures.
View Article and Find Full Text PDFEcotoxicol Environ Saf
February 2025
Background: The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity of noise that impair health is crucial for developing effective interventions. The study aimed to determine the acute noise intensity thresholds that elicit anxiety-like behaviors and brain damage in female rats, and then to elucidate the underlying neurobiological mechanisms.
View Article and Find Full Text PDFInjectable hydrogels offer a minimally invasive approach to treating intervertebral disc degeneration, a prevalent condition that affects 90% of individuals and often leads to significant pain and disability. Despite being a critical yet often overlooked issue that could lead to suboptimal therapeutic outcomes, the mechanical integrity of these gels frequently diminishes postinjection due to the injection process itself. To address this challenge, our research developed a silk-nanofibril-based hydrogel enhanced through simple polymerization of dopamine.
View Article and Find Full Text PDFDespite escalating interest in distinguishing among various types of venture capitalists (VCs) and their roles in shaping entrepreneurship and innovation, such research remains sparse in the world's second-largest VC market, i.e., China.
View Article and Find Full Text PDFBackground: Researchers gradually focus on the relationship between phage and cancer.
Objective: To summarize the research hotspots and trends in the field of bacteriophage and cancer.
Methods: The downloaded articles were searched from the Web of Science Core Collection database from January 2008 to June 2023.
Fertilized agricultural soil is a significant source of gaseous nitrogen compounds (GNCs), including NO, NO, HONO, and NH. The North China Plain (NCP) is the "hot region" for the release of these GNCs due to intensive fertilization practices. However, existing research has primarily focused on NO emissions from fertilized farmland in the NCP, lacking comprehensive observational studies on other GNCs.
View Article and Find Full Text PDFBackground: Gut bacteria are related to colorectal cancer (CRC) and its clinicopathologic characteristics.
Objective: To develop gut bacterial subtypes and explore potential microbial targets for CRC.
Methods: Stool samples from 914 volunteers (376 CRCs, 363 advanced adenomas, and 175 normal controls) were included for 16S rRNA sequencing.
Background: Pancreatic cancer (PCA) is an extremely aggressive malignant cancer with an increasing incidence and a low five-year survival rate. The main reason for this high mortality is that most patients are diagnosed with PCA at an advanced stage, missing early treatment options and opportunities. As important nutrients of the human body, trace elements play an important role in maintaining normal physiological functions.
View Article and Find Full Text PDFClin Transl Immunology
June 2024
In recent years, bacteria have gained considerable attention as a promising drug carrier that is critical in improving the effectiveness and reducing the side effects of anti-tumor drugs. Drug carriers can be utilised in various forms, including magnetotactic bacteria, bacterial biohybrids, minicells, bacterial ghosts and bacterial spores. Additionally, functionalised and engineered bacteria obtained through gene engineering and surface modification could provide enhanced capabilities for drug delivery.
View Article and Find Full Text PDFThe common cutworm, (F.), feeds on a wide variety of food and cash crops and is one of the most widespread and destructive agricultural pests worldwide. Migration is the biological basis of its regional population outbreaks but the seasonal movement of this pest between east and south Asia regions remains unknown.
View Article and Find Full Text PDFBackground: Gut bacteria have an important influence on colorectal cancer (CRC). The differences of gut bacteria between genders have been the hot spots.
Objective: To analyze the relationship between gut bacteria and gender differences in patients with CRC.
Severe ozone (O) pollution has been a major air quality issue and affects environmental sustainability in China. Conventional mitigation strategies focusing on reducing volatile organic compounds and nitrogen oxides (NO) remain complex and challenging. Here, through field flux measurements and laboratory simulations, we observe substantial nitrous acid (HONO) emissions () enhanced by nitrogen fertilizer application at an agricultural site.
View Article and Find Full Text PDFWith the rapid development of histological techniques and the widespread application of single-cell sequencing in eukaryotes, researchers desire to explore individual microbial genotypes and functional expression, which deepens our understanding of microorganisms. In this review, the history of the development of microbial detection technologies was revealed and the difficulties in the application of single-cell sequencing in microorganisms were dissected as well. Moreover, the characteristics of the currently emerging microbial single-cell sequencing (Microbe-seq) technology were summarized, and the prospects of the application of Microbe-seq in microorganisms were distilled based on the current development status.
View Article and Find Full Text PDFCancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial factor, energy metabolism influences the activation, proliferation, and function of T cells, and thus metabolic reprogramming of T cells is a unique research perspective in cancer immunology. Special conditions within the tumor microenvironment and high-energy demands lead to alterations in the energy metabolism of T cells.
View Article and Find Full Text PDFBackground: Gut microbiota dysbiosis involved in the pathogenesis of colorectal cancer (CRC). The characteristics of enterotypes in CRC development have not been determined.
Objective: To characterize the gut microbiota of healthy, adenoma, and CRC subjects based on enterotype.
Peroxyacetyl nitrate (PAN) is an important photochemical pollutant in the troposphere, whereas long-term measurements are scarce in rural areas in North China Plain (NCP), resulting in unclear seasonal variations and sources of PAN in rural NCP. In this study, we conducted a 1-year observation of PAN during 2021-2022 at the rural NCP site. The average concentrations of PAN were 1.
View Article and Find Full Text PDFHigh cholesterol is an important factor inducing colorectal cancer (CRC). The study aims to determine the key genes and regulatory mechanism associated with tumor-infiltrating T cells underlying cholesterol-induced CRC. Gene expression data and clinical data from CRCS in The Cancer Genome Atlas (TCGA) were selected for differential expression and survival analysis.
View Article and Find Full Text PDFFront Cell Dev Biol
November 2023
As a novel antioxidant, a growing body of studies has documented the diverse biological effects of molecular hydrogen (H) in a wide range of organisms, spanning animals, plants, and microorganisms. Although several possible mechanisms have been proposed, they cannot fully explain the extensive biological effects of H. Mitochondria, known for ATP production, also play crucial roles in diverse cellular functions, including Ca signaling, regulation of reactive oxygen species (ROS) generation, apoptosis, proliferation, and lipid transport, while their dysfunction is implicated in a broad spectrum of diseases, including cardiovascular disorders, neurodegenerative conditions, metabolic disorders, and cancer.
View Article and Find Full Text PDFBackground: The most common toxic side effect after chemotherapy, one of the main treatments for colorectal cancer (CRC), is myelosuppression.
Objective: To analyze the correlation between gut microbiota and leukopenia after chemotherapy in CRC patients.
Methods: Stool samples were collected from 56 healthy individuals and 55 CRC patients.
Cell mediated immune escape, a microenvironment factor, induces tumorigenesis and metastasis. The purpose of this study was to display the characteristics of T cell populations in immune microenvironments for colorectal cancer (CRC) metastasis. Unsupervised cluster analysis was conducted to identify functionally distinct T cell clusters from 3,003 cells in peripheral blood and 4,656 cells in tissues.
View Article and Find Full Text PDFSci Total Environ
November 2023
Despite considerable decreases in fine particulate matter (PM) in Chinese megacities over the past decade, many second- and third-tier cities that distribute abundant industrial enterprises are still facing great challenges for PM further reduction under the recent policy background of eliminating heavily-polluted weather. In view of core effects of NO on PM, the deeper reductions of NO in these cities are expected to break the plateau of PM decline, however, the link between NO emission and PM mass loading is currently lacking. Herein, we progressively construct an evaluation system for PM productions based on daily NO emissions in a typical industrial city (Jiyuan), considering a sequence of nested parameters involving evolutions of NO into nitric acid and then nitrate, and contributions of nitrate to PM.
View Article and Find Full Text PDFAims: As the ovaries age and women transition to menopause and postmenopause, reduced estradiol levels are associated with anxiety and depression. Exercise contributes to alleviate anxiety and depression and the bone-derived hormone osteocalcin has been reported to be necessary to prevent anxiety-like behaviors. The aim of this study was to investigate the effects of exercise on anxiety behaviors in climacteric mice and whether it was related to osteocalcin.
View Article and Find Full Text PDFAn efficient and stable bifunctional oxygen catalyst is necessary to complete the application of the rechargeable zinc-air battery. Herein, an economical and convenient process was adopted to successfully coat high-entropy alloy FeNiCrCoMn nanoparticles on carbon nanotubes (CNTs). In 0.
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