Publications by authors named "Yifei Qian"

Article Synopsis
  • Postoperative abdominal adhesion (PAA) is a common complication after abdominal surgery, but the role of Ligustrazine nanoparticles (LN) in its prevention is not fully understood.
  • In rat experiments, LN reduced the formation of adhesions by lowering inflammation markers and inhibiting epithelial-mesenchymal transition (EMT) pathways, suggesting it helps in tissue repair.
  • These findings indicate that LN could be a promising treatment for PAA, but more clinical studies are needed to confirm its effectiveness in humans.
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Background And Aims: The immunosuppressive tumor microenvironment (TME) plays an essential role in cancer progression and immunotherapy response. Despite the considerable advancements in cancer immunotherapy, the limited response to immune checkpoint blockade (ICB) therapies in patients with hepatocellular carcinoma (HCC) remains a major challenge for its clinical implications. Here, we investigated the molecular basis of the protein O-fucosyltransferase 1 (POFUT1) that drives HCC immune evasion and explored a potential therapeutic strategy for enhancing ICB efficacy.

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Article Synopsis
  • Driver genomic mutations in tumors, like TP53 mutations in hepatocellular carcinoma (HCC), significantly affect malignancy, therapy resistance, and patient outcomes.
  • In TP53 mutant HCC, fatty acid β oxidation (FAO) is notably suppressed, leading to poor patient prognosis and tumor progression due to the downregulation of the enzyme carnitine palmitoyltransferase 1 (CPT1A).
  • The loss of CPT1A disrupts lipid metabolism and activates mTOR signaling pathways, making TP53 mutant liver cancers more sensitive to mTOR inhibitors like AZD-8055, suggesting a potential therapeutic strategy for these patients.
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Background: ChuShiWeiLing Decoction (CSWLD) is a famous classical Chinese prescription for the treatment of eczema with desirable effect in clinical practice. It has gradually exerted good curative effects on perianal eczema (PE) in recent years, but its specific mechanism is not elucidated yet.

Objective: This research explores the underlying pharmacological mechanism of CSWLD in addressing PE through network pharmacology combined with molecular docking strategy.

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Background: Hepatocellular carcinoma (HCC) is one of the major causes of death from cancer and has a very poor prognosis with few effective therapeutic options. Despite the approval of lenvatinib for the treatment of patients suffering from advanced HCC, only a small number of patients can benefit from this targeted therapy.

Methods: Diethylnitrosamine (DEN)-CCL4 mouse liver tumour and the xenograft tumour models were used to evaluate the function of KDM6A in HCC progression.

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Background And Aims: Epigenetic plasticity is a major challenge in cancer-targeted therapy. However, the molecular basis governing this process has not yet been clearly defined. Despite the considerable success of poly(ADP-ribose) polymerase inhibitors (PARPi) in cancer therapy, the limited response to PARPi, especially in HCC, has been a bottleneck in its clinical implications.

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Animal abundance estimation is increasingly based on drone or aerial survey photography. Manual postprocessing has been used extensively; however, volumes of such data are increasing, necessitating some level of automation, either for complete counting, or as a labour-saving tool. Any automated processing can be challenging when using such tools on species that nest in close formation such as penguins.

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Background: Postoperative abdominal adhesions formation is considered a significant clinical entity implicating the healing process following major pelvic and abdominal surgery, with serious clinical complications and need for substantial health care expenditures. However, setting a physical barrier between the damage site and the neighboring tissues is a convenient and highly valid way to minimize or prevent peritoneal adhesions. The present experimental study evaluated the preventive effect of ligustrazine nanoparticles nano spray (LNNS) on postoperative abdominal adhesion in rats and explored its mechanism.

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Synopsis of recent research by authors named "Yifei Qian"

  • * The studies highlight potential therapeutic vulnerabilities in TP53-mutated liver cancer and propose innovative strategies to enhance the effectiveness of immune checkpoint blockade (ICB) and targeted therapies like lenvatinib.
  • * Additionally, Qian explores complementary areas such as the pharmacological mechanisms of traditional Chinese medicine in treating conditions like perianal eczema and advancements in automated animal counting in ecological research through aerial imaging.

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