[Ploidy and whole genome Survey of Pinellia ternata].

Pinellia ternata, a widely distributed species in China, has been used as a herbal medicine for centuries, with the effects of drying dampness and resolving phlegm. However, its complex ploidy and lack of whole-genome map limit in-depth research on molecular-assisted breeding and multi-omics. In this study, flow cytometry was employed to evaluate the genome sizes of 144 P.

Shifting evaluative construal: Common and distinct neural components of moral, pragmatic, and hedonic evaluations.

People generate evaluations of different attitude objects based on their goals and aspects of the social context. Prior research suggests that people can shift between at least three types of evaluations to judge whether something is good or bad: (how costly or beneficial it is), (whether it is aligned with moral norms), and (whether it feels good; Van Bavel et al., 2012).

Systematic review of interventions to promote colorectal cancer screening: Benchmarking effect sizes and screening rates.

Objective: The effectiveness of behavioral interventions is typically evaluated relative to control conditions using null hypothesis significance testing (i.e., < .

Identification of multiple novel viruses in bar-headed goose feces from Tibet of China.

Introduction: The bar-headed goose is a typical high-altitude bird that primarily inhabits alpine lakes and wetlands in Central Asia, with a remarkable ability to adapt to high elevations. Previous studies have shown that they can be infected with parasites such as Cryptosporidium spp. At present, there were few reports on its infection with the virus.

Molecular quantification of fritillariae cirrhosae bulbus and its adulterants.

Background: Fritillariae Cirrhosae Bulbus (FCB) is frequently adulterated with its closely related species due to personal or non-man made factors, leading to alterations in the composition of its constituents and compromising the efficacy of its products.

Methods: The specific single nucleotide polymorphisms (SNPs) were screened by comparing candidate barcodes of Fritillaria and verified by amplification and sequencing. Herb molecular quantification (Herb-Q) was established by detecting specific SNPs, and the methodological validation was performed.

USP26 as a hepatitis B virus-induced deubiquitinase primes hepatocellular carcinogenesis by epigenetic remodeling.

Despite recent advances in systemic therapy for hepatocellular carcinoma (HCC), the prognosis of hepatitis B virus (HBV)-induced HCC patients remains poor. By screening a sgRNA library targeting human deubiquitinases, we find that ubiquitin-specific peptidase 26 (USP26) deficiency impairs HBV-positive HCC cell proliferation. Genetically engineered murine models with Usp26 knockout confirm that Usp26 drives HCC tumorigenesis.

Constructing Three-Dimensional Architectures to Design Advanced Copper-Based Current Collector Materials for Alkali Metal Batteries: From Nanoscale to Microscale.

Alkali metals (Li, Na, and K) are deemed as the ideal anode materials for next-generation high-energy-density batteries because of their high theoretical specific capacity and low redox potentials. However, alkali metal anodes (AMAs) still face some challenges hindering their further applications, including uncontrollable dendrite growth and unstable solid electrolyte interphase during cycling, resulting in low Coulombic efficiency and inferior cycling performance. In this regard, designing 3D current collectors as hosts for AMAs is one of the most effective ways to address the above-mentioned problems, because their sufficient space could accommodate AMAs' volume expansion, and their high specific surface area could lower the local current density, leading to the uniform deposition of alkali metals.

Molecular quantification of herbs (Herb-Q): a pyrosequencing-based approach and its application in Pinellia ternata.

Variations in herb dosage due to species adulteration and dosing inaccuracies can substantially affect clinical safety and efficacy. Accurate species quantification remains challenging, as current methods often yield inconsistent results. This study introduces a novel pyrosequencing-based technique, termed herb molecular quantification (Herb-Q), designed to precisely quantify herbal products.

Chemoradiotherapy-induced ACKR2 tumor cells drive CD8 T cell senescence and cervical cancer recurrence.

Tumor recurrence after chemoradiotherapy is challenging to overcome, and approaches to predict the recurrence remain elusive. Here, human cervical cancer tissues before and after concurrent chemoradiotherapy (CCRT) analyzed by single-cell RNA sequencing reveal that CCRT specifically promotes CD8 T cell senescence, driven by atypical chemokine receptor 2 (ACKR2) CCRT-resistant tumor cells. Mechanistically, ACKR2 expression is increased in response to CCRT and is also upregulated through the ligation of CC chemokines that are produced by activated myeloid and T cells.

Transcriptomic and metabolomic profiling provide insight into the role of sugars and hormones in leaf senescence of Pinellia ternata.

The interaction network and pathway map uncover the potential crosstalk between sugar and hormone metabolisms as a possible reason for leaf senescence in P. ternata. Pinellia ternata, an environmentally sensitive medicinal plant, undergoes leaf senescence twice a year, affecting its development and yield.

An immune sandwich electrochemical biosensor based on triple-modified zirconium derivatives for detection of CD146 in serum.

CD146, also known as melanoma cell adhesion molecule (MCAM), is overexpressed in various cancer patients, making it a valuable predictor for early diagnosis. In this work, an immune sandwich electrochemical biosensor is proposed for sensitive and non-invasive quantitative detection of CD146 in serum. Zirconium-based MOF (UIO-66) was modified by simultaneous copper atom doping, in situ growth carbon-based support and physical embedding of platinum nanoparticles (PtNPs).

Association of positive childhood experiences with flourishing among children with ADHD: A population-based study in the United States.

Background: Child flourishing includes healthy social and emotional development and an open, engaged approach to learning. However, there remains a significant knowledge gap concerning a minority of children with ADHD who may demonstrate flourishing in one or more areas of functioning. This study investigated the association between positive childhood experiences (PCEs) and flourishing among children with ADHD.

A bidirectional thermal sensory leaky integrate-and-fire (LIF) neuron model based on bipolar NbO volatile threshold devices with ultra-low operating current.

Brain-like artificial intelligence (AI) will become the main form and important platform in future computing. It will play an important and unique role in simulating brain functions, efficiently implementing AI algorithms, and improving computing power. Developing artificial neurons that can send facilitation/depression signals to artificial synapses, sense, and process temperature information is of great significance for achieving more efficient and compact brain-like computing systems.

Memristors based on NdNiO nanocrystals film as sensory neurons for neuromorphic computing.

By mimicking the behavior of the human brain, artificial neural systems offer the possibility to further improve computing efficiency and solve the von Neumann bottleneck. In particular, neural systems with perceptual capability expand the application field and lay a good foundation for the construction of perceptual storage and computational systems. However, research on neurons with perceptual functions is still relatively scarce, with most works focusing on optoelectronic synapses.

Network structure of mobile phone addiction and anxiety symptoms among rural Chinese adolescents.

Background: The incidence of mobile phone addiction among adolescents in rural areas of China is increasing year by year, and has already exceeded that of some cities. And phone addiction increases the risk of anxiety and poor sleep. Therefore, this study used network analysis to investigate the relationship between mobile phone addiction and anxiety symptoms, and the predictability to sleep quality.

Pathway from interpersonal sensitivity to depression among Chinese college students during the COVID-19 campus lockdown.

Background: Due to the continuous spread of the epidemic, some colleges and universities have implemented a campus lockdown management policy in China. In the context of the campus lockdown, this study aimed to explore whether anxiety mediated the association between interpersonal sensitivity and depression, and investigate whether psychological capital moderated the indirect or direct effect of mediation model.

Methods: A total of 12945 undergrad students were recruited in China from April 10 to 19, 2022.

Association between brachial-ankle pulse wave velocity and microvascular complications in type 2 diabetes mellitus.

Purpose/aim: To investigate the relationship between brachial-ankle pulse wave velocity (baPWV) and microvascular complications in type 2 diabetes mellitus (T2DM).

Materials And Methods: From 2019 to 2021, our hospital enrolled 322 patients with T2DM. Clinical information and biochemical indicators of patients were collected from the inpatient electronic medical record system and analyzed retrospectively.

The association between Chinese eye exercises and myopia in children and adolescents: A systematic review and meta-analysis.

Objective: This study aims to summarize the relevant evidence on the association between eye exercises and myopia in children and adolescents in China.

Methods: The meta-analysis pooled the results of 12 studies, with a total of 134,201 participants. Another five studies (no OR for myopia as an outcome and meeting inclusion criteria) were reported in the systematic review.

Network connectivity between anxiety, depressive symptoms and psychological capital in Chinese university students during the COVID-19 campus closure.

Background: In the context of the outbreak of COVID-19 within mainland China, to understand the mental health status of university students during campus closure, this study analyzes the relationship between anxiety, depressive symptoms, and psychological capital and to reveals their central symptoms.

Methods: A total of 12,945 university students were included in this study from April 10 to 19, 2022. Anxiety and depressive symptoms were measured by the seven-item Generalized Anxiety Disorder Scale (GAD-7) and two-item Patient Health Questionnaires (PHQ-2).