Publications by authors named "Yifei Lin"

Aims: Effective therapeutic drugs for calcific aortic valve disease (CAVD) are lacking, although its incidence has been increasing over the past decade, and is predicted to continue rising in the future. This study aimed to explore the role and potential mechanisms of liver X receptor α (LXRα) in CAVD, which offers a promising approach for treating CAVD.

Methods And Results: Osteogenic stimulation was performed following which a substantial downregulation of LXRα was observed in human calcific aortic valves and in valvular interstitial cells.

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Background: Recently, some observational studies have suggested potential associations between erectile dysfunction (ED) and respiratory function. However, the underlying biological mechanisms and causal relationships between ED and lung function require further investigation. This study aimed to explore the causalities between ED and lung function traits.

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  • The study explores the genetic connections between Hunner interstitial cystitis (HIC) and autoimmune diseases (ADs), suggesting they may share common genetic factors.
  • Utilizing a large East Asian population, the researchers employed advanced statistical methods like Mendelian randomization to assess causal relationships and identify genetic markers linked to both conditions.
  • Results showed causal effects of certain autoimmune conditions on HIC and vice versa, along with insights into genetic variants affecting gene expression in autoimmune-related tissues, highlighting a potential shared genetic basis for these diseases.
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  • The study examines the long-term impact of the COVID-19 pandemic on nurses' mental health, highlighting increased levels of psychological distress and PTSD over time.
  • A survey of 8,785 registered nurses in China indicated a significant rise in psychological distress from 27.7% at the beginning to 57.6% later, with PTSD rates climbing from 7.8% to 14.7%.
  • Coping strategies were found to influence psychological distress and PTSD levels, while social support played a crucial role in protecting against severe mental health issues.
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Background: The precise association between green tea intake and gastrointestinal disorders remains controversial. This study aimed to investigate the potential causal association between green tea intake and gastrointestinal disorders through a two-sample Mendelian randomization (MR) study.

Methods: Utilizing publicly accessible data from genome-wide association studies (GWAS), we identified SNPs strongly linked with the study variables from multiple large databases to serve as instrumental variables (IVs).

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  • Stress urinary incontinence (SUI) is a common issue in women caused by urethral sphincter failure, with varied prevalence rates impacted by research methods and underreporting.
  • This study uses Mendelian randomization to investigate how SUI correlates with lipid and glucose metabolism, analyzing data from large populations in the UK Biobank and ENGAGE consortium.
  • Results indicate that higher levels of total cholesterol, LDL, and HDL are linked to an increased risk of SUI, while higher fasting glucose and insulin are associated with a reduced risk, suggesting a complex relationship between metabolic factors and SUI in women.
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  • - This study investigates the causal relationship between benign prostatic hyperplasia (BPH) and cardiovascular diseases (CVDs), focusing on five specific conditions: stroke, coronary heart disease (CHD), heart failure, myocardial infarction (MI), and atrial fibrillation (AF).
  • - Using genetic data from several databases, the analysis found that BPH increases the risk for CHD and MI, but decreases the risk for stroke, suggesting a complex relationship between these conditions.
  • - The results indicate BPH might serve as a risk factor for some CVDs while offering some protection against stroke, and further research with larger sample sizes is recommended to clarify these associations.
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Stacking two-dimensional (2D) van der Waals (vdW) materials in a layered bulk structure provides an appealing platform for the emergence of exotic physical properties. As a vdW crystal with exceptional plasticity, InSe offers the opportunity to explore various effects arising from the coupling of its peculiar mechanical behaviors and other physical properties. Here, we employ neutron scattering techniques to investigate the correlations of plastic interlayer slip, lattice anharmonicity, and thermal transport in InSe crystals.

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As machine learning progresses, techniques such as neural networks, decision trees, and support vector machines are being increasingly applied in the medical domain, especially for tasks involving large datasets, such as cell detection, recognition, classification, and visualization. Within the domain of bone marrow cell morphology analysis, deep learning offers substantial benefits due to its robustness, ability for automatic feature learning, and strong image characterization capabilities. Deep neural networks are a machine learning paradigm specifically tailored for image processing applications.

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Background: Epidemiological studies have revealed a significant association between impaired kidney function and certain mental disorders, particularly bipolar disorder (BIP) and major depressive disorder (MDD). However, the evidence regarding shared genetics and causality is limited due to residual confounding and reverse causation.

Methods: In this study, we conducted a large-scale genome-wide cross-trait association study to investigate the genetic overlap between 5 kidney function biomarkers (eGFRcrea, eGFRcys, blood urea nitrogen (BUN), serum urate, and UACR) and 2 mental disorders (MDD, BIP).

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The ways that risk assessments are commonly performed in organizations have limitations that undermine their quality. They typically focus on individual risk events one at a time but are weak at integrating their relevant causal context, into decision-making processes. Network topology analysis has previously been applied to address this weakness through quantitatively characterizing the importance of the causal interactions of risk events.

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Introduction: Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early life, including smoking during adolescence and maternal smoking during pregnancy, can affect adolescent development and lead to several negative outcomes.

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Marital status is an independent prognostic factor for survival in many types of cancers, but its prognostic impact on patients with prostate cancer (PCa) has not been established. The aim of this study was to explore the independent prognostic factors of PCa and to investigate the effect of marital status on survival outcomes in patients with different stratified by PCa. Using the surveillance, epidemiology, and end results (SEER) database, we collected data on 584,655 PCa patients diagnosed between 1975 and 2019.

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  • Premenstrual disorders (PMDs) are prevalent among young women and may be linked to metabolic issues, with limited research on dietary impacts.
  • A study involving 1,382 young women in China identified three dietary patterns: Traditional North China Diet, Traditional South China Diet, and Lacto-ovo Vegetarian Diet.
  • The Traditional South China Diet, high in rice and meat, was found to significantly reduce the risk of PMDs, suggesting dietary changes could help prevent these disorders.
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Background: The relaxation of the "zero-COVID" policy on Dec. 7, 2022, in China posed a major public health threat recently. Complete blood count test was discovered to have complicated relationships with COVID-19 after the infection, while very few studies could track long-term monitoring of the health status and identify the characterization of hematological parameters prior to COVID-19.

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Background: Following an initiative published by Lancet in 2002 and an IDEAL-D framework, the value of preclinical animal studies has garnered increasing attention in recent research. Numerous preclinical animal experiments tried to generate evidence to guide the development of barbed sutures. However, discernible drawbacks and incongruities in outcomes have emerged between clinical and preclinical animal studies.

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Introduction: Magnetic resonance imaging (MRI) staging scans are critical for the diagnosis and treatment of patients with nasopharyngeal cancer (NPC). We aimed to evaluate the application value of LAVA-Flex and T1WI-IDEAL sequences in MRI staging scans.

Methods: Eighty-four newly diagnosed NPC patients underwent both LAVA-Flex and T1WI-IDEAL sequences during MRI examinations.

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Background: Atrial fibrillation (AF) is one of the most common persistent arrhythmias among adult cardiovascular diseases. It is important to identify potential risk factors for AF. Members of the insulin-like growth factor (IGF) family exert a variety of effects on various cell types in the context of the pathogenesis of cardiovascular diseases, and previous population-based studies indicate associations between IGF family members and AF.

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Hyaluronic acid is a major component of extracellular matrix which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (Heterocephalus glaber) contains abundant high-molecular-mass hyaluronic acid in its tissues, which contributes to this species' cancer resistance and possibly to its longevity. Here we report that abundant high-molecular-mass hyaluronic acid is found in a wide range of subterranean mammalian species, but not in phylogenetically related aboveground species.

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Background: Numerous observational epidemiological studies have reported a bidirectional relationship between periodontitis and urological cancers. However, the causal link between these two phenotypes remains uncertain. This study aimed to examine the bidirectional causal association between periodontitis and four types of urological tumors, specifically kidney cancer (KC), prostate cancer (PC), bladder cancer (BC), and testis cancer (TC).

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Background: The barbed suture, which can eliminate knot tying and accelerate the placement of sutures, is an innovative type of suture, whereas the benefits of cosmetic surgeries (CS) are controversial. This study aimed to comprehensively evaluate the effectiveness and safety of barbed sutures in CS.

Method: PubMed, EMBASE, Cochrane Library, and ClinicalTrials.

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Aims: Left ventricular remodelling subsequent to myocardial infarction (MI) constitutes a pivotal underlying cause of heart failure. Intervention with the nontoxic endogenous aryl hydrocarbon receptor (AHR) agonist 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) in the acute phase of MI has been shown to ameliorate cardiac function, but its role in the chronic phase remains obscured. This study explores the beneficial role of ITE in delaying the progression of heart failure in the chronic phase of MI.

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Background And Objectives: Disease severity and prognosis of coronavirus disease 2019 (COVID-19) disease with other viral infections can be affected by the oropharyngeal microbiome. However, limited research had been carried out to uncover how these diseases are differentially affected by the oropharyngeal microbiome of the patient. Here, we aimed to explore the characteristics of the oropharyngeal microbiota of COVID-19 patients and compare them with those of patients with similar symptoms.

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Hyaluronic acid (HA) is a major component of extracellular matrix (ECM) which plays an important role in development, cellular response to injury and inflammation, cell migration, and cancer. The naked mole-rat (NMR, ) contains abundant high-molecular-mass HA (HMM-HA) in its tissues, which contributes to this species' cancer resistance and possibly longevity. Here we report that abundant HMM-HA is found in a wide range of subterranean mammalian species, but not in phylogenetically related aboveground species.

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