Selenoprotein-Mediated Redox Regulation Shapes the Cell Fate of HSCs and Mature Lineages.

The maintenance of cellular redox balance is crucial for cell survival and homeostasis and is disrupted with aging. Selenoproteins, comprising essential antioxidant enzymes, raise intriguing questions about their involvement in hematopoietic aging and potential reversibility. Motivated by our observation of mRNA downregulation of key antioxidant selenoproteins in aged human hematopoietic stem cells (HSCs) and previous findings of increased lipid peroxidation in aged hematopoiesis, we employed tRNASec gene (Trsp) knockout (KO) mouse model to simulate disrupted selenoprotein synthesis.

Progress of Researches on Pharmacological Effects and Bioavailability of Tangeretin.

Tangeretin is one of the most abundant polymethoxyflavones in citrus peel and its pharmacological effects are extremely rich. However, due to its poor solubility, bitter taste and poor oral bioavailability, the oral administration of tangeretin is still limited, which seriously limits its application in industrial production. The establishment of encapsulation and delivery systems to improve bioavailability is an effective method.

Imidazole-Functionalized Zn-MOFs for One-Step CH Purification from CH/CH/CH Ternary Mixture.

The discovery of new structures is very important for metal-organic framework (MOF) adsorbents and their application in gas separation, where the design of ligands and the selection of metal ions play a decisive role. Herein, we synthesized two isoreticular Zn-MOFs, UPC-250 and UPC-251, composed of imidazole-based tricarboxylic acid ligands and binuclear zinc clusters. The pore environment was regulated via modifying fluorine atoms at different positions of ligands, and one-step purification of ethylene from acetylene/ethylene/ethane ternary mixture was realized in UPC-251.

High-pressure chemistry of functional materials.

Functional materials, possessing specific properties and performing particular functions beyond their mechanical or structural roles, are the foundation of modern matter science including energy, environment, and quantum sciences. The atomic and electronic structures of these materials can be significantly altered by external stimuli such as pressure. High-pressure techniques have been extensively utilized to deepen our understanding of structure-property relationships of materials, while also enabling emergent or enhanced properties.

Bio-inspired modification of nanocellulose based on in-situ homogeneous radical coupling of coniferin.

A bioinspired method for surface modification of nanocellulose has been proposed, drawing inspiration from the lignification process in plant cell walls. Unlike traditional methods for synthesizing dehydrogenation polymers (DHPs) of lignin, this study innovatively prepared a water-soluble DHPs precursor, coniferin, which underwent homogeneous polymerization catalyzed by peroxidase to generate DHPs that adhered to the surface of nanocellulose. Modified nanocellulose was then filtered into membranes, and the presence of DHPs increased the water contact angle, achieving high hydrophobicity with little DHPs content.

Efficacy and safety of aspirin in preventing venous thromboembolism after hip arthroplasty for femoral neck fracture: a noninferiority prospective cohort study.

Background: Venous thromboembolism (VTE) is a common complication after hip arthroplasty. Here, we investigated the clinical efficacy and safety of prophylactic aspirin vs. conventional therapy in hip arthroplasty for femoral neck fracture.

Disulfiram impairs USP21-mediated MOF-K257 deubiquitination to inhibit esophageal squamous cell carcinoma progression.

Disulfiram (DSF), primarily applied in the therapy for alcohol addiction, has been demonstrated to possess the promising capability of anti-tumor in many human cancers, including esophageal squamous cell carcinoma (ESCC). To date, almost all studies about DSF in ESCC are focusing on investigating either drug combinations or nanoparticle-based delivery systems. However, the exact molecular mechanisms mediating the response to DSF in ESCC are totally unknown.

A Recombinant Human Collagen and RADA-16 Fusion Protein Promotes Hemostasis and Rapid Wound Healing.

In this study, we designed a fusion protein, rhCR, by combining human collagen with the self-assembling peptide RADA-16 using genetic engineering technology. The rhCR protein was successfully expressed in . The rhCR can self-assemble into a three-dimensional nanofiber network under physiological conditions.

[Carbon Emission Analysis and Carbon Reduction Strategy of Small and Medium-scale Municipal Wastewater Treatment Plants in Cities and Towns].

The carbon emissions of three typical processes （AAO, MSBR, and oxidation ditch） were systematically analyzed from the perspective of the whole wastewater treatment process based on the annual data of eleven urban small and medium-scale WWTPs in the year 2022, and the effects of different influent characteristics （TP, TN, BOD, COD, influent volume, and COD/TN） on the carbon emissions were studied by using the partial least squares structural equation modeling （PLS-SEM） method. The results showed that indirect carbon emissions dominated the total carbon emissions of small and medium-scale WWTPs （69.5%）, and carbon emissions from electricity consumption were the largest source （43.

Associations of weekend compensatory sleep and weekday sleep duration with psychotic-like experiences among Chinese adolescents.

Objective: Insufficient sleep on weekdays among adolescents and its negative effects on mental health is a concerning public health issue. This study examined the relationship between weekday sleep duration, weekend compensatory sleep (WCS), and psychotic-like experiences (PLEs) in a large sample of Chinese adolescents.

Methods: A total of 39,731 junior high school students were recruited in this cross-sectional study.

Changes in insomnia symptoms among compulsory education students in China after the "Double Reduction" policy: a two-wave longitudinal study.

Objective: In July 2021, the "Double Reduction" policy was introduced in China, aiming to alleviate the burden of excessive homework and off-campus tutoring for students in the compulsory education stage. The purpose of this study is to explore the changes in students' insomnia symptoms and related factors after the policy implementation. Meanwhile, sex differences were further examined.

Unconventional Interconnected High-Entropy Alloy Nanodendrites for Remarkably Efficient C-C Bond Cleavage toward Complete Ethanol Oxidation.

Developing ethanol oxidation electrocatalysts with high catalytic activity, durability, and resistance to CO poisoning remains a major challenge. High-entropy alloys (HEAs) with unique physical and chemical properties have garnered substantial attention. Herein, a class of HEA nanodendrites are designed by a simple wet-chemical method.

Buyang Huanwu Decoction prevents hemorrhagic transformation after delayed t-PA infusion via inhibiting NLRP3 inflammasome/pyroptosis associated with microglial PGC-1α.

Ethnopharmacological Relevance: Delayed tissue-type plasminogen activator (t-PA) thrombolysis, which has a restrictive therapeutic time window within 4.5 h following ischemic stroke (IS), increases the risk of hemorrhagic transformation (HT) and subsequent neurotoxicity. Studies have shown that the NLRP3 inflammasome activation reversely regulated by the PGC-1α leads to microglial polarization and pyroptosis to cause damage to nerve cells and the blood-brain barrier.

Self-crystal electret poly(lactic acid) nanofibers for high-flow air purification and AI-assisted respiratory diagnosis.

Particulate matters (PMs), one of the major airborne pollutants, continue to seriously threaten human health and the environment. Here, a self-crystal-induced electret enhancement (SCIEE) strategy was developed to promote the in-situ electret effect and polarization properties of electrospun poly(L-lactic acid) (PLLA) nanofibers. The strategy specifically involved the elaborate pre-structuring of stereocomplex crystals (SCs) with uniform dimensions (∼300 nm), which were introduced into PLLA electrospinning solution as the electrets and physical cross-linking points of high density.

The association between triglyceride to high-density-lipoprotein cholesterol ratio and calcific aortic valve disease: a retrospective study.

Background: The ratio of triglycerides to high-density-lipoprotein cholesterol (TG/HDL-C) is increasingly recognized as a practical marker for insulin resistance and cardiovascular risk assessment. This retrospective study investigates the potential of the TG/HDL-C ratio to predict the development of calcific aortic valve disease (CAVD), thereby extending its applicability in cardiovascular diagnostics.

Methods: Data from 400 individuals, comprising 200 patients with diagnosed CAVD and 200 matched healthy controls, were analyzed.

Enhancing pharmacogenomic data accessibility and drug safety with large language models: a case study with Llama3.1.

Pharmacogenomics (PGx) holds the promise of personalizing medical treatments based on individual genetic profiles, thereby enhancing drug efficacy and safety. However, the current landscape of PGx research is hindered by fragmented data sources, time-consuming manual data extraction processes, and the need for comprehensive and up-to-date information. This study aims to address these challenges by evaluating the ability of Large Language Models (LLMs), specifically Llama3.

Correction methods and applications of ERT in complex terrain.

Electrical Resistivity Tomography (ERT) is an efficient geophysical exploration technique widely used in the exploration of groundwater resources, environmental monitoring, engineering geological assessment, and archaeology. However, the undulation of the terrain significantly affects the accuracy of ERT data, potentially leading to false anomalies in the resistivity images and increasing the complexity of interpreting subsurface structures. This paper reviews the progress in the research on terrain correction for resistivity methods since the early 20th century.

Chromogenic Photonic Crystal Detectors for Monitoring Small Molecule Diffusion at Solid-Solid Interfaces Using Stimuli-Responsive Shape Memory Polymers.

In situ monitoring of small molecule diffusion at solid-solid interfaces is challenging, even with sophisticated equipment. Here, novel chromogenic photonic crystal detectors enabled by integrating bioinspired structural color with stimuli-responsive shape memory polymer (SMP) for detecting trace amounts of small molecule interfacial diffusion are reported. Colorless macroporous SMP membranes with deformed macropores can recover back to the "memorized" photonic crystal microstructures and the corresponding iridescent structural colors when triggered by diffused small molecules.

Screening and evaluation of diabetic retinopathy a deep learning network model: A prospective study.

Background: Diabetic retinopathy (DR) is one of the most common serious complications in diabetic patients, and early screening and diagnosis are essential to prevent visual impairment. With the rapid development of deep learning technology, network models based on attention mechanisms have shown significant advantages in medical image analysis, which can improve the accuracy and efficiency of screening.

Aim: To evaluate the efficacy of an attention mechanism-based deep learning network model in screening for DR in natural and diabetic populations, as well as in screening with unilateral and bilateral fundus photography.

High-efficiency respiratory protection and intelligent monitoring by nanopatterning of electroactive poly(lactic acid) nanofibers.

The advent of multifunctional nanofibrous membranes (NFMs) has led to the development of next-generation air filters that are ready to intercept fine particulate matters (PMs) and monitor the respiratory diseases. However, it is still challenging to fabricate biodegradable NFMs featuring the desirable combination of high filtration efficiencies, low air resistance, and intelligent real-time monitoring. Herein, a hierarchical nanopatterning approach was proposed to functionalize the stereocomplexed poly(lactic acid) (PLA) (SC-PLA) nanofibers via the combined electrospinning of SC-PLA and electrospray of CNT@ZIF-8 nanohybrids.

Bacteria-based biohybrids for remodeling adenosine-mediated immunosuppression to boost radiotherapy-triggered antitumor immune response.

Radiotherapy (RT) can trigger immunogenic cell death (ICD) in tumor cells and release adenosine triphosphate (ATP) to activate antitumor immunity. However, the formation of immunosuppressive adenosine (ADO) mediated by ectonucleotidases including CD39 and CD73, can exacerbate the immunosuppressive effects. Herein, a radiosensitizer-based metal-organic framework (MOF) composed of bismuth (Bi) and ellagic acid (EA) was synthesized in situ on the surface of Escherichia coli Nissle 1917 (EcN) to serve as a carrier for the CD39 inhibitor sodium polyoxotungstate (POM-1).