Aggregation induced emission luminogen bacteria hybrid bionic robot for multimodal phototheranostics and immunotherapy.

Multimodal phototheranostics utilizing single molecules offer a "one-and-done" approach, presenting a convenient and effective strategy for cancer therapy. However, therapies based on conventional photosensitizers often suffer from limitations such as a single photosensitizing mechanism, restricted tumor penetration and retention, and the requirement for multiple irradiations, which significantly constrain their application. In this report, we present an aggregation-induced emission luminogen (AIEgen) bacteria hybrid bionic robot to address above issues.

Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.

Effects of Fermented Liquid Feed with Compound Probiotics on Growth Performance, Meat Quality, and Fecal Microbiota of Growing Pigs.

Feed fermentation enhances feed nutrition and animal health, but its impact on the gut microbiota of young pigs remains unclear. This study aimed to evaluate the effects of a probiotic fermented feed, which includes , , , and , on the growth performance, meat quality, and intestinal microbiota of growing pigs. We randomly assigned 24 Duroc × Landrace × Landrace pigs to two groups: a control (Ctrl) group and the fermented liquid feed (FLF) group, with three replicate pens per group and four pigs per pen.

High level of initial Aspergillus fumigatus-specific IgE links increased risk of exacerbation in allergic bronchopulmonary aspergillosis patients.

Background: Elevated Aspergillus fumigatus (A. fumigatus)-specific Immunoglobulin E (IgE) is recognized as an essential diagnostic criterion for allergic bronchopulmonary aspergillosis (ABPA). However, it remains unknown whether initial A.

Multicenter analysis on the correlation between the anatomical characteristics of hepatic veins and hepatic venous wedge pressure.

Background: Wedged hepatic venous pressure (WHVP) is a crucial variable for accurately assessing the hepatic venous pressure gradient (HVPG) and is vital for the diagnosis and prognostic evaluation of patients with portal hypertension (PH).

Aim: To investigate the anatomical characteristics of balloon-occluded hepatic venous angiography in patients with PH and analyze the relationship between the WHVP and portal venous pressure (PVP).

Methods: This retrospective study included 877 patients with PH who met the inclusion criteria from January 2020 to June 2024.

Rapid antibiotic biosensors based on multiple molecular recognition elements.

The extensive use of antibiotics poses significant public health concerns, including the increase in drug-resistant bacteria and environmental pollution, underscoring the urgent need for rapid, sensitive, and specific antibiotic detection methods. Most current reviews on antibiotic detection primarily focus on categorizing antibiotics based on their types or the classification of sensors used, such as electrochemical, optical, or colorimetric sensors. In contrast, this review proposes a novel and systematic theoretical framework for the detection of antibiotics using sensors using seven popular molecular recognition elements-antibodies, aptamers, microorganisms, cells, peptides, molecularly imprinted polymers (MIPs), metal-organic frameworks (MOFs) and direct recognition modalities and briefly discusses the mechanism of molecular recognition elements and antibiotic recognition.

Influencing factors of depressive symptoms during pregnancy in Beijing, China.

Objective: Prenatal depression is a prevalent mental health challenge encountered during pregnancy and is notably associated with adverse maternal and neonatal outcomes. This study aimed to elucidate the likelihood and determinants of depressive symptoms among pregnant individuals in Beijing, thereby laying a foundational framework for the theoretical underpinning of prenatal screening and preemptive interventions for mental disorders.

Methods: The study dataset was derived from 4,564 pregnant individuals in Beijing utilizing a cross-sectional survey methodology.

[Application of optogenetic technology in the research on olfactory bulb neural projection from advanced brain regions to regulate olfactory signal processing].

Olfactory bulb is a critical component in encoding and processing olfactory signals, characterized by its intricate neural projections and networks dedicated to this function. It has been found that descending neural projections from the olfactory cortex and other advanced brain regions can modulate the excitability of olfactory bulb output neurons in the olfactory bulb, either directly or indirectly, which can further influence olfactory discrimination, learning, and other abilities. In recent years, advancements in optogenetic technology have facilitated extensive application of neuron manipulation for studying neural circuits, thereby greatly accelerating research into olfactory mechanisms.

Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma.

Background Aims: The prognoses and therapeutic responses of patients with intrahepatic cholangiocarcinoma (iCCA) depend on spatial interactions among tumor microenvironment (TME) components. However, the spatial TME characteristics of iCCA remain poorly understood. The aim of this study was to generate a comprehensive spatial atlas of iCCA using artificial intelligence-assisted spatial multiomics patterns and to identify spatial features associated with prognosis and immunotherapy.

Estimated size of the total genome and protein space of viruses.

Recent metagenomic studies have identified a vast number of viruses. However, the systematic assessment of the true genetic diversity of the whole virus community on our planet remains to be investigated. Here, we explored the genome and protein space of viruses by simulating the process of virus discovery in viral metagenomic studies.

Nasal or Submandibular Intubation for Anesthesia in Orthognathic Surgery to Correct Jaw Deformities Secondary to Cleft Lip and Palate: Which One Is the Optimal Choice?

The aim of this retrospective study is to investigate the optimal airway management of orthognathic surgery anesthesia for correcting jaw deformity secondary to cleft lip and palate (CLP) by comparing the differences between nasal and submandibular intubation. Preoperative (T0), 1 week postoperatively (T1), and 6 months postoperatively (T2) CT scans and vital signs after oral intubation (S0), before reconnection of the submandibular tracheal catheter (S1), and after reconnection (S2) were collected from 54 patients who received nasal intubation (Group I) and submandibular intubation (Group II). The results were evaluated using 3D reconstruction and analysis in Mimics.

[Identification of Differences in Brain Functions at Varied Degrees of Acclimatization to High Altitudes Based on Resting-State Electroencephalogram Signals].

Objective: To explore the differences in brain functions between individuals with good acclimatization to high altitudes and those with poor acclimatization based on microstate and functional connectivity analysis of resting-state electroencephalogram (EEG) activities.

Methods: A total of 44 residents exposed to the high-altitude environment of 3650 m above sea level were enrolled. They were divided into two groups according to their findings for the high-altitude acclimatization index (AAI), with 22 in the good acclimatization group and 22 in the poor acclimatization group.

A bioinspired microbial taste chip with artificial intelligence-enabled high selectivity and ultra-short response time.

Real-time water pollution monitoring is crucial as global water pollution has become an urgent issue endangering the health of humanity. Microbial taste chips are promising for water pollution monitoring due to the advantages of short response time and real-time monitoring capability. However, although more than 200 journal research articles on microbial taste chips have been reported to date, sensor selectivity, which is the foremost critical parameter, remains an unsolved challenge even after utilizing gene-editing techniques.

Dietary quality and adherence to dietary recommendations in Chinese patients with chronic kidney disease.

Objectives: There is a lack of data regarding the quality of the diet and the adherence to dietary guidelines of patients with non-dialysis-dependent CKD (NDD-CKD) in China.

Design And Methods: Single-center cross-sectional study of 261 patients with CKD stages 3-5, who responded to 3-day dietary records and undertook 24-h urine samples along with clinical, laboratory, and anthropometric assessments. We compared their food intake with Chinese recommendations for CKD patients, assessed dietary quality through the Chinese Healthy Eating Index (CHEI), and calculated the contribution to energy intake by processed foods according to the NOVA classification.

Machine learning approaches for predicting fetal macrosomia at different stages of pregnancy: a retrospective study in China.

Background: Macrosomia presents significant risks to both maternal and neonatal health, however, accurate antenatal prediction remains a major challenge. This study aimed to develop machine learning approaches to enhance the prediction of fetal macrosomia at different stages of pregnancy.

Methods: This retrospective study involved 500 pregnant women who delivered singleton infants at Beijing Tsinghua Changgung Hospital between December 2019 and July 2024.

Unprecedented female mutation bias in the aye-aye, a highly unusual lemur from Madagascar.

Every mammal studied to date has been found to have a male mutation bias: male parents transmit more de novo mutations to offspring than female parents, contributing increasingly more mutations with age. Although male-biased mutation has been studied for more than 75 years, its causes are still debated. One obstacle to understanding this pattern is its near universality-without variation in mutation bias, it is difficult to find an underlying cause.

The 1-acylglycerol-3-phosphate acyltransferase Slc1 is required to regulate mitochondria and lipid droplets.

Mitochondria are organelles involved in energy metabolism and biosynthesis. As the metabolites released from mitochondria are raw materials used for lipid synthesis, mitochondria also play important roles in lipid metabolism. Here we report that Slc1, a 1-acylglycerol-3-phosphate O-acyltransferase in the fission yeast Schizosaccharomyces pombe, is required to maintain tubular mitochondrial morphology and normal mitochondrial functions.

Association between oxidative balance score and glaucoma in the National Health and Nutrition Examination Survey.

Objective: To investigate the association between Oxidative Balance Score (OBS) and glaucoma risk.

Methods: Using data from the National Health and Nutrition Examination Survey (2005-2008), we analyzed 2,615 participants aged ≥40 years. OBS was calculated from 15 antioxidant and 5 pro-oxidant components, including dietary nutrients and lifestyle factors.

Atomistic Origin of Microsecond Carrier Lifetimes at Perovskite Grain Boundaries: Machine Learning-Assisted Nonadiabatic Molecular Dynamics.

The polycrystalline nature of perovskites, stemming from their facile solution-based fabrication, leads to a high density of grain boundaries (GBs) and point defects. However, the impact of GBs on perovskite performance remains uncertain, with contradictory statements found in the literature. We developed a machine learning force field, sampled GB structures on a nanosecond time scale, and performed nonadiabatic (NA) molecular dynamics simulations of charge carrier trapping and recombination in stoichiometric and doped GBs.

Ultrafast Charge Carrier Dynamics in Vanadium Dioxide, VO: Nonequilibrium Contributions to the Photoinduced Phase Transitions.

Vanadium oxide (VO) is an exotic phase-change material with diverse applications ranging from thermochromic smart windows to thermal sensors, neuromorphic computing, and tunable metasurfaces. Nonetheless, the mechanism responsible for its metal-insulator phase transition remains a subject of vigorous debate. Here, we investigate the ultrafast dynamics of the photoinduced phase transition in VO under low perturbation conditions.

Enhancement of titanium surfaces using different acid solutions at room temperature to improve bone cell responses.

Background/purpose: Early osseointegration of titanium (Ti) dental implants relies on the surface topography. Surface modification of Ti seeks to enhance bone regeneration around implants. Acid etching is the simple, less technique sensitive and cost-effective technique for surface treatment.

Improving osteogenic properties of zirconia ceramic via glow discharge plasma-enhanced deposition of amine organic compound.

Background/purpose: Osseointegration potential is greatly depended on the interaction between bone cells and dental implant surface. Since zirconia ceramic has a bioinert surface, functionalization of the surface with an organic compound allylamine was conducted to overcome its drawback of minimal interaction with the surrounding bone.

Materials And Methods: The zirconia surface was initially treated with argon glow discharge plasma (GDP), then combined with amine plasma at three different conditions of 50-W, 75-W and 85-W, to prepare the final samples.

Probiotic biofilm modified scaffolds for facilitating osteomyelitis treatment through sustained release of bacteriophage and regulated macrophage polarization.

Osteomyelitis has gradually become a catastrophic complication in orthopedic surgery due to the formation of bacterial biofilms on the implant surface and surrounding tissue. The therapeutic challenges of antibiotic resistance and poor postoperative osseointegration provide inspiration for the development of bioactive implants. We have strategically designed bioceramic scaffolds modified with (LR) and bacteriophages (phages) to achieve both antibacterial and osteogenic effects.

The Experience of Adults' Family Caregivers Using Home Care Services: A Scoping Review.

Aim: To review the experiences of family caregivers using home care services, the perception of home care services and the positive and negative effects on family caregivers.

Design: A scoping review of the literature was undertaken using JBI guidance.

Data Sources: Databases were searched in November 2023, including PubMed, Web of Science, Embase, CINAHL, Cochrane Library and CNKI (China National Knowledge Infrastructure).

Participants' satisfaction with social security is closely associated with their acceptance of vulnerable groups: a nationwide cross-sectional study in China.

Introduction: Social security, as a core component of the national welfare system, has consistently played a crucial role in ensuring the basic livelihood of citizens and promoting social equity and justice. Against this backdrop, this study explores the association between social security satisfaction and acceptance of vulnerable groups.

Methods: This study involved 9923 participants.