Bistable soliton optical frequency combs in a second-harmonic generation Kerr cavity.

We study the dynamics and stability of soliton optical frequency comb generation in a dissipative, coherently pumped cavity with both second- and third-order nonlinearity. Cavity sweep simulations and linear stability analysis based on path continuation reveal the existence of bistable solitons. These families of solitons represent a continuous transition between a purely quadratic and a Kerr cavity soliton frequency comb.

Unveiling distinct representations of P3a in schizophrenia through two-stimulus and three-stimulus auditory oddball paradigms.

Background: P3a event-related potential (ERP) is considered a potential biomarker for schizophrenia (SZ), can be elicited through both passive two-stimulus and active three-stimulus auditory oddball paradigms. While both types of P3a reflect involuntary attention shifts, the nuanced understanding of what P3a represents in different contexts is important and rarely studied. This study aims to examine correlations between P3a ERPs elicited from different paradigms and associations of each P3a with cognitive function, clinical symptoms, and antipsychotic medication.

Ultrafast cell-free DNA extraction from body fluids using UiO-66-NH hydrogel packed syringe.

Liquid biopsy represents a noninvasive or minimally invasive diagnostic approach relevant for both the organ-specific changes and systemic health conditions, whereas cell-free DNA (cfDNA) extraction from body liquids has attracted much attention in liquid biopsy, especially. Nowadays, metal-organic frameworks (MOF) such as UiO-66-NH has been demonstrated efficient extraction property for DNA molecular, whereas the disadvantages of MOF for solid-phase extraction (SPE) still remain. Herein, one macro-pored MOF hydrogel formation strategy was constructed in this study to achieve superb extraction performance of cfDNAs from body fluids.

A Static-Dynamic Composition Framework for Efficient Action Recognition.

The dynamic inference, which adaptively allocates computational budgets for different samples, is a prevalent approach for achieving efficient action recognition. Current studies primarily focus on a data-efficient regime that reduces spatial or temporal redundancy, or their combination, by selecting partial video data, such as clips, frames, or patches. However, these approaches often utilize fixed and computationally expensive networks.

Serotonin Mitigates ColdStress-Induced Damage in Through Modulating the Endogenous Melatonin- and Abscisic Acid Biosynthesis.

Endogenous melatonin (MEL) and abscisic acid (ABA) are involved in the adaptation of plants to environmental stresses. The application of exogenous serotonin (SER) to plants can enhance their tolerance to abiotic stress, such as cold. However, the mechanism associated with serotonin-mediated defense against cold-induced damage in mangroves is still poorly understood.

Harnessing organic electrolyte for non-corrosive and wide-temperature Na-Cl battery.

Rechargeable sodium-chlorine (Na-Cl) batteries show great promise in grid energy storage applications due to their high electrochemical performance. However, the use of highly corrosive thionyl chloride (SOCl)-based electrolytes has severely hindered their real-world applications. Here we show a non-corrosive ester (methyl dichloroacetate) as a promising alternative to SOCl, which can form a non-corrosive electrolyte with aluminum chloride and sodium bis(fluorosulfonyl)imide for high-performance rechargeable Na-Cl batteries.

Non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio as a biomarker for liver health: Insights from National Health and Nutrition Examination Survey data.

The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a lipid-related biomarker, remains underexplored in relation to the risk of advanced fibrosis and hepatic steatosis. The present study aimed to investigate the potential association between the NHHR and these hepatic conditions. A total of 6,907 individuals aged 20 years and older from the National Health and Nutrition Examination Survey 2017-2020 were included in the present study.

Pathologic characteristics and management strategies for two categories of prostate cancer patients with low prostate-specific antigen undergoing radical prostatectomy.

Background: Prostate cancer (PCa) with low levels of prostate-specific antigen (PSA) (0-4 ng/mL) includes PCa detected through biopsy and incidental PCa (IPC) in patients with previous prostate surgeries. The study was conducted to compare these two groups of patients undergoing radical prostatectomy (RP), aiming to assess pathological characteristics and suggest strategies for predicting and managing low PSA PCa.

Methods: A retrospective analysis was performed on two categories of low PSA PCa patients.

Separation of the active components from the residue of Schisandra chinensis via an ultrasound-assisted method.

A novel and efficient method, namely Solid-state fermentation combined with ionic liquid pretreatment and ultrasonic-assisted extraction (SSFIPU), was successfully established for the extraction of anthocyanins (ACs) from Schisandra chinensis residue samples. Additionally, an enzymatic combined with ionic liquid pretreatment and ultrasonic-assisted extraction technique (EIPU) was effectively developed to extract Schisandrin A (SDA) and Schizandrin B (SDB) from the residue after AC extraction. A comprehensive examination was conducted on ten crucial parameters of SSFIPU and eight essential parameters of EIPU.

New insights into the association between arthritis and overactive bladder in NHANES 2005-2020.

Arthritis and overactive bladder (OAB) are both common diseases, but the association between them remains unclear. The aim of our research is to investigate the possible link with regard to arthritis and OAB. Our study's data was sourced from the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2020.

Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma.

Arsenic trioxide (ATO), the active ingredient in Chinese arsenic, effectively inhibits hepatocellular carcinoma (HCC) cell growth, but its clinical application is limited by the lack of a targeted delivery system. Phosphatidylinositol proteoglycan 3 (GPC3) is specifically expressed in HCC, and CPP44 is a cell-penetrating peptide that targets HCC cells. Here, we developed a liposome incorporating ATO with dual surface modifications of anti-GPC3 antibody and CPP44.

A physics informed neural network approach to quantify antigen presentation activities at single cell level using omics data.

Antigen processing and presentation via major histocompatibility complex (MHC) molecules are central to immune surveillance. Yet, quantifying the dynamic activity of MHC class I and II antigen presentation remains a critical challenge, particularly in diseases like cancer, infection and autoimmunity where these pathways are often disrupted. Current methods fall short in providing precise, sample-specific insights into antigen presentation, limiting our understanding of immune evasion and therapeutic responses.

Neural Correlates of Social Perception Deficit in Schizophrenia: An Event-related Potential Study.

Background: Deficits in emotion recognition have been shown to be closely related to social-cognitive functioning in schizophrenic. This study aimed to investigate the event-related potential (ERP) characteristics of social perception in schizophrenia patients and to explore the neural mechanisms underlying these abnormal cognitive processes related to social perception.

Methods: Participants included 33 schizophrenia patients and 35 healthy controls (HCs).

, A Precious Rare Fungus With Good Pharmaceutical and Food Value.

is a rare porous fungus that exhibits notable pharmacological activities. Particularly, due to its diuretic properties, it is considered an important source of targeted drugs for the treatment of kidney disease. Extensive research has been conducted on this fungus, focusing not only on its challenging cultivation techniques but also on its diverse array of medicinal ingredients, including polysaccharides and steroids.

Engineered 3D DNA Crystals: A Molecular Design Perspective.

Recent advances in biomolecular self-assembly have transformed material science, enabling the creation of novel materials with unparalleled precision and functionality. Among these innovations, 3D DNA crystals have emerged as a distinctive class of macroscopic materials, engineered through the bottom-up approach by DNA self-assembly. These structures uniquely combine precise molecular ordering with high programmability, establishing their importance in advanced material design.

Non-Invasive Prenatal Diagnosis of Chromosomal and Monogenic Disease by a Novel Bioinspired Micro-Nanochip for Isolating Fetal Nucleated Red Blood Cells.

Purpose: Fetal nucleated red blood cells (fNRBCs) in the peripheral blood of pregnant women contain comprehensive fetal genetic information, making them an ideal target for non-invasive prenatal diagnosis (NIPD). However, challenges in identifying, enriching, and detecting fNRBCs limit their diagnostic potential.

Methods: To overcome these obstacles, we developed a novel biomimetic chip, replicating the micro-nano structure of red rose petals on polydimethylsiloxane (PDMS).

The addition of vermiculite reduced antibiotic resistance genes during composting: Novel insights based on reducing host bacteria abundance and inhibiting plasmid-mediated conjugative transfer.

Antibiotic resistance genes (ARGs) are prevalent in raw materials used for composting. The utilization of eco-friendly materials for the removal of ARGs is regarded as an economically effective method. Therefore, this study focused on the impact of incorporating different proportions of vermiculite (0% (CK), 5% (T1), and 10% (T2)) on the dynamics of ARGs during composting.

Quantum search algorithm on weighted databases.

The Grover algorithm is a crucial solution for addressing unstructured search problems and has emerged as an essential quantum subroutine in various complex algorithms. By using a different approach with previous studies, this research extensively investigates Grover's search methodology within non-uniformly distributed databases, a scenario frequently encountered in practical applications. Our analysis reveals that the behavior of the Grover evolution differs significantly when applied to non-uniform databases compared to uniform or 'unstructured databases'.

Bisphenol A impairs oocyte maturation by dysfunction of cumulus cells.

Bisphenol A (BPA) is a well-known environmental endocrine disruptor that has detrimental effects on reproduction. This study aimed to investigate whether BPA exposure could disrupt the function of cumulus cells and influence oocyte maturation and development. Porcine oocytes at the germinal vesicle stage were exposed to BPA for 44 h.

Exogenous additives reshape the microbiome and promote the reduction of resistome in co-composting of pig manure and mushroom residue.

Comprehensive understanding of the microbiome and resistome evolution in compost is crucial for guaranteeing the safety of organic fertilizers. Current studies using different composting systems and sequencing technologies have yielded varying conclusions on the efficacy of exogenous additives (EAs) in reducing antibiotic resistance genes (ARGs) in compost. This study employed metagenomics to investigate the impact of various EAs on microbial communities, ARGs, their coexistence with mobile genetic elements (MGEs), and ARG hosts in co-composting.

Metagenomic insights into the mechanism of sophorolipid in facilitating co-anaerobic digestion of mushroom residues and cattle manure: Functional microorganisms and metabolic pathway analysis.

The present study aimed to enhance the co-anaerobic digestion system of mushroom residues and cattle manure by incorporating biosurfactant sophorolipid. Results demonstrated that the addition of 75 mg/L sophorolipid increased cumulative methane production by 33.68%, acetate content by 9-10 times, and the abundance of Methanosarcina by 69.

Zhachong Shisanwei pill drug-containing serum protects HO-Induced PC12 cells injury by suppressing apoptosis, oxidative stress via regulating the MAPK signaling pathway.

Introduction: Zhachong Shisanwei Pill (ZSP) is a classical Mongolian formula that combines 13 types of Chinese medicinal materials and has been used for treating ischemic stroke (IS) for centuries. However, the underlying molecular mechanisms have yet to be fully elucidated. The aim of this study is to explore potential mechanism of ZSP on nerve cells in cerebral ischemic injury.