Plant-based Diet and Chronic Kidney Disease: A Systematic Review and Meta-analysis.

Objective: We aimed to perform a systematic review and meta-analyses to evaluate the impact of plant-based diet (PBD) on chronic kidney disease (CKD).

Methods: A systematic search of PubMed and Embase was conducted from inception to August 2023 to evaluate the association between adopting a PBD and the incidence, progression, and mortality of CKD. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random-effects model.

Young adult partner phubbing and relationship satisfaction: the mediating role of attachment anxiety and the moderating role of constructive conflict coping style.

Introduction: This study investigates the association between young adult partner phubbing and relationship satisfaction, with a focus on the mediating role of attachment anxiety and the moderating role of constructive conflict coping styles (voice or loyalty). Understanding these dynamics is crucial for enhancing relationship satisfaction among young adults.

Methods: A sample of 837 undergraduate students (376 male students; average age 21.

Alterations in brain iron and myelination in children with ASD: A susceptibility source separation imaging study.

Autism spectrum disorder (ASD) may have both brain iron and myelin changes, but traditional methods fail to differentiate them. This study utilized an advanced susceptibility source separation technique, APART-QSM (iterAtive magnetic suscePtibility sources sepARaTion), to investigate brain iron and myelination alterations in children with ASD and link neuroimaging findings to clinical symptom severity. Sixty-five school-aged children with ASD and Sixty age- and sex-matched typically developing children were included.

Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis.

Background: Sirt6-mediated gut microbiota plays a vital role in poststroke depression (PSD). Icariside Ⅱ (ICS Ⅱ) is a naturally-occurring neuroprotectant with Sirt6 induction potency. However, it is unknown whether ICS Ⅱ protects against PSD through modulation of gut microbiota.

Preparation of Polydeoxyribonucleotide Nanoliposomes and their Applicability to Cosmetic Formulations.

Introduction: The use of polydeoxyribonucleotide (PDRN) in promoting tissue repair and anti-aging has been hindered by several challenges, including its large molecular weight, susceptibility to decomposition, low bioavailability, and poor stability and skin permeability. Liposome formulation technology has emerged as a promising method in cosmetics, enhancing the penetration and protection of active ingredients.

Method: In this study, a PDRN-loaded nanoliposomal (PDRN-NL) formulation, which exhibited an average particle size of 125 ± 1 nm, a polydispersity index (PDI) of 0.

Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation.

AGR2 is a pro-oncogenic protein overexpressed in multiple cancer types, and it promotes tumor progression. Therefore, it is regarded as a promising therapeutic target for cancer. We reported the development and antitumor mechanism of AGR2-specific monoclonal antibody 18A4.

Recent Advances in Cationic Nanoemulsions for Drug Delivery: Preparation, Properties, and Applications.

Nanoemulsions have gained popularity as drug delivery vehicles owing to the enhanced solubility of insoluble drugs, the augmented stability of photo- and thermosensitive substances, and the facilitation of transdermal permeation of efficacy substances. As the cell surfaces of the skin, cornea, gastrointestinal mucosa, and other cells in living organisms carry negative charges, cationic nanoemulsions (CNE) mainly promote drug absorption through electrostatic effects. In this review, a brief characterization of CNEs is provided, and the types of cationic agents and their roles in nanoemulsions, including cationic surfactants, cationic lipids, cationic polymers, cationized polysaccharides, and phytosphingosine (PS), are discussed.

An innovative application of osmotic microbial fuel cell (OsMFC) for enhanced activated sludge thickening and stabilization with bioelectricity generation.

Waste activated sludge (WAS) management presents significant challenges due to its complex composition and the high cost associated with conventional treatment methods. This study investigates the potential of osmotic microbial fuel cell (OsMFC) technology for WAS thickening, stabilization, and bioelectricity generation. Compared to conventional microbial fuel cells (MFCs), OsMFCs offer several advantages, including enhanced sludge thickening performance, improved organic matter degradation efficiency, and increased bioelectricity generation.

The association between type 2 diabetes and asthma incidence: a longitudinal analysis considering genetic susceptibility.

Background: The prevalence of type 2 diabetes (T2D) and asthma is rising, yet evidence regarding the relationship between T2D and asthma, particularly in the context of genetic predispositions, remains limited.

Methods: This study utilized data from the UK Biobank longitudinal cohort, involving 388,775 participants. A polygenic risk score (PRS) for asthma was derived from genome-wide association studies summary.

CRISPR/Cas12a with Universal crRNA for Indiscriminate Virus Detection.

Viruses, known for causing widespread biological harm and even extinction, pose significant challenges to public health. Virus detection is crucial for accurate disease diagnosis and preventing the spread of infections. Recently, the outstanding analytical performance of CRISPR/Cas biosensors has shown great potential and they have been considered as augmenting methods for reverse-transcription polymerase chain reaction (RT-PCR), which was the gold standard for nucleic acid detection.

Targeting Siglec-15 mediates mitochondrial retrograde regulation of cervical cancer development.

Cervical cancer (CCA) is the predominant cause of fatalities from gynecologic malignancies, with metastasis responsible for 80 % of cancer-related mortalities. This study preliminarily examined the involvement of Sialic Acid Binding Ig Like Lectin 15 (Siglec-15) in the development of CCA and its probable mechanisms. We assessed the capacity of Siglec-15 to modulate CCA progression by establishing knockdown and overexpression Siglec-15 cell lines, supplemented with animal models, using both in vivo and in vitro dual investigations.

The Value of LC-MS/MS in Apparent Bilateral Aldosterone Suppression in Adrenal Venous Sampling for Primary Aldosteronism.

Context: Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA), however, it is unreliable when apparent bilateral aldosterone suppression (ABAS) occurs, defined as aldosterone/cortisol ratio in the adrenal vein being bilaterally lower than that in the inferior vena cava. The value of Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in PA subtyping when ABAS occurs is unclear.

Objective: To determine whether LC-MS/MS can reduce the occurrence of ABAS and misdiagnosis of PA subtyping.

Comparison of a chemiluminescence immunoassay with LC-MS/MS in the determination of the plasma aldosterone concentration in patients with impaired renal function.

Purpose: Compared with chemiluminescence immunoassay (CLIA), the quantification of the plasma aldosterone concentration (PAC) via liquid chromatography-tandem mass spectrometry (LC-MS/MS) yields lower values. The extent to which this difference is exacerbated by a reduced glomerular filtration rate (eGFR) is unclear. Therefore, this study aims to assess the impact of renal insufficiency on PAC as measured by CLIA using LC-MS/MS as the reference method.

Discontinuous Directional Wetting Transitions in Polymeric Droplets on the Heterogeneous Microcavity Surface.

The wetting transition behaviors of polymeric droplets on microcavity surfaces are familiar and play a vital role in micromanufacturing, microfluidics, and printing industries. Despite previous research indicating that microcavity surfaces can precisely control the droplet wetting state, the understanding of the complex effects of droplet spreading, surface morphology, and property of polymeric droplet on wetting transitions remains incomplete. The air-liquid interfaces (ALIs) typically arise from the entrapped air beneath the droplet on microcavity surfaces, adopting a metastable wetting state caused by either bubble escape or dissolution.

Hollow-structured Zn-doped CeO mesoporous spheres boost enhanced antioxidant activity and synergistic bactericidal effect.

The increasing prevalence of antibiotic-resistant bacteria is regarded as one of the worst threats to the environment and global health, and antimicrobial nanomaterials have been increasingly explored to provide solutions for antimicrobial resistance problems. In this paper, mesostructured Zn-doped CeO hollow spheres (ZDCHS) with various Zn/Ce ratios were successfully prepared by a conventional one-pot hydrothermal synthesis method. The ingenious incorporation of Zn playing a vital role in the fabrication of hollow structure of ZDCHS with high specific surface area, and detailed transmission electron microscopy (TEM) characterization confirmed the homogeneous distribution of Zn element across the ZDCHS.

Effect of Different Doping Concentrations on the Properties of Fe:ZnSe and Fe, Cr:ZnSe Crystals Grown by the Chemical Vapor Transport Method.

The Fe:ZnSe crystal is an important material for 3-5 μm mid-infrared lasers. In this work, we have grown different doping concentrations of Fe:ZnSe and Fe, Cr:ZnSe by the chemical vapor transport method. The doped crystals have the same structure.

Belimumab safety in adult and paediatric Chinese patients with systemic lupus erythematosus: A Phase 4, multicentre, observational study.

Objective: Although belimumab has been widely used in patients with systemic lupus erythematosus (SLE) globally, real-world safety data among Chinese patients are limited, particularly for children. This study assessed the safety and tolerability of belimumab in adult and paediatric patients with SLE in China in real-world clinical practice.

Methods: This Phase 4, multicentre, prospective, observational study enrolled patients prescribed intravenous belimumab by their physicians in tertiary hospitals, independent of a clinical study, during routine clinical visits between May 2021 and May 2022.

Smart Green Cotton Textiles with Hierarchically Responsive Conductive Network for Personal Healthcare and Thermal Management.

Whereas cotton as an abundant natural cellulose has been widely used for sustainable and skin-friendly textiles and clothes, developing cotton fabrics with smart functions that could respond to various stimuli is still eagerly desired while remaining a great challenge. Herein, smart multiresponsive cotton fabric with hierarchically copper nanowire interwoven MXene conductive networks that are seamlessly assembled along a 3D woven fabric template for efficient personal healthcare and thermal comfort regulation is successfully developed. The robust hierarchically interwoven conductive network was "glued" and protected by organic conductive polymer poly(3,4-ethylenedioxythiophene) along a 3D interconnected fabric template to enhance interfacial adherent and environmental stability.

Preparation and Characterization of Universal Liquid Proliposomes Encapsulating Water-soluble Efficacious Substances.

Introduction: Liposomes were extensively used for cosmetics and pharmaceuticals due to their versatility, biocompatibility, and biodegradability, as well as the ability to encapsulate water-soluble and fat-soluble substances. However, some challenges remain unsolved, including poor stability, complex preparation process, limited encapsulation efficiencies (EE%) and drug loading capacity (DLC%).

Method: We herein prepared universal liquid proliposomes by rotary evaporation method and optimized formulations with different pH, glycerol content, ethanol content and preparation process.

Differential diagnosis of benign and lung adenocarcinoma presenting as larger solid nodules and masses based on multiscale CT radiomics.

Purpose: To develop a better radiomic model for the differential diagnosis of benign and lung adenocarcinoma lesions presenting as larger solid nodules and masses based on multiscale computed tomography (CT) radiomics.

Materials And Methods: This retrospective study enrolled 205 patients with solid nodules and masses from Center 1 between January 2010 and February 2022 and Center 2 between January 2019 and February 2022. After applying the inclusion and exclusion criteria, we retrospectively enrolled 165 patients from two centers and assigned them to the training dataset (n = 115) or the test dataset (n = 50).

Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis.

Over 50 billion cells undergo apoptosis each day in an adult human to maintain tissue homeostasis by eliminating damaged or unwanted cells. Apoptotic deficiency can lead to age-related diseases with reduced apoptotic metabolites. However, whether apoptotic metabolism regulates aging is unclear.