Pivotal influence of solution chemistry on electrosorption-enhanced membrane filtration performance: Implication for study of electrified membrane processes.

Electrified membrane separation exhibits a multitude of intriguing qualities coveted for next-generation water purification technologies. For practical wastewater treatment scenarios, integrated electrified ultrafiltration (EUF) enables simultaneous enhancement in membrane fouling inhibition, pollutant rejection, and desalination efficiency. Elucidating the complex mechanism of the influence of solution chemistry on the efficiency of EUF treatment is one of the most crucial challenges dominating its further application.

The relationship between the Huanglongbing pathogen and Diaphorina citri with body color polyphenism: field dynamics, acquisition efficiency, and immunity response.

Background: Phenotypic plasticity is generally regarded as a crucial adaptation that enables organisms to survive in the face of environmental changes. Diaphorina citri, a vector of Candidatus Liberibacter asiaticus (CLas) that causes citrus Huanglongbing, displays three distinct body color morphotypes: blue/green, gray/brown, and orange/yellow morphs. Here, dynamics monitoring of D.

tRF-3a-Pro: A Transfer RNA-Derived Small RNA as a Novel Biomarker for Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most challenging malignancies of the digestive system. Screening for novel biomarkers and therapeutic targets is a promising strategy to enhance HCC prognosis. Recently, liquid biopsy with circulating nucleic acids as the detection targets has attracted much attention in the field of early screening of tumours.

Evaluation of binding interaction between compounds targeting peroxisome proliferator-activated receptor γ in Nelumbinis folium using receptor chromatography and molecular dynamic simulation.

Despite considerable efforts invested in clinical trials aimed at treating obesity and enhancing the metabolic profiles of Nelumbinis Folium, the precise phytochemicals involved and their mechanisms of action remain unclear due to the absence of an efficient screening technique. Herein, Nelumbinis Folium serves as the focal point to elucidate the bioactive compounds that specifically bind to peroxisome proliferator-activated receptor γ using immobilized receptor chromatography. Following identification through liquid chromatography-mass spectrometry, the compounds were further evaluated using chromatographic techniques and molecular dynamics simulations.

Molecular Photoelectrodes with Enhanced Photogenerated Charge Transport for Efficient Solar Hydrogen Evolution.

Photoelectrocatalytic cells for seawater splitting have shown promise toward large-scale deployment; however, challenges remain in operation performances, which outline clear research needs to scale up photoelectrodes with small loss of efficiency. Here, we report an approach for scalable and robust solar H evolution by enhancing photogenerated charge transport in a H-evolving molecular photoelectrode. The photoelectrode is based on p-type conjugated polymers that are homogeneously distributed in a polycarbazole network.

Emergence of Voronoi-Patterned Cellular Membranes via Confinement Transformation of Self-Assembled Metal-Organic Frameworks.

The self-assembly of nanoparticles allows the fabrication of complex, nature-inspired architectures. Among these, Voronoi tessellations─intricate patterns found in many natural systems such as insect wings and plant tissues─have broad implications across materials science, biology, and geography. However, replicating these irregular yet organized features at the nanoscale through nanoparticle self-assembly remains challenging.

Land system changes of terrestrial tipping elements on Earth under global climate pledges: 2000-2100.

Tipping elements on Earth are components that undergo rapid and irreversible changes when climate change reaches a tipping point. They are highly sensitive to climate variations and serve as early warning signs of global change. Human activities, including global climate pledges, significantly influence the climate and the state of tipping elements.

Multimodal large language models address clinical queries in laryngeal cancer surgery: a comparative evaluation of image interpretation across different models.

Background And Objectives: Recent advances in multimodal large language models (MLLMs) have shown promise in medical image interpretation, yet their utility in surgical contexts remains unexplored. This study evaluates six MLLMs' performance in interpreting diverse imaging modalities for laryngeal cancer surgery.

Methods: We analyzed 169 images (X-rays, CT scans, laryngoscopy, and pathology findings) from 50 patients using six state-of-the-art MLLMs.

Bacterial and fungal diversity and species interactions inversely affect ecosystem functions under drought in a semi-arid grassland.

Extreme climatic events, such as drought, can significantly alter belowground microbial diversity and species interactions, leading to unknown consequences for ecosystem functioning. Here, we simulated a drought gradient by removing 30 %, 50 %, and 70 % of precipitation in a semi-arid grassland over five years. We assessed the effects of drought on bacterial and fungal diversity, as well as on their species interactions.

Photosensitive Hybrid γδ-T Exosomes for Targeted Cancer Photoimmunotherapy.

Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness and can lead to systemic side effects. Photodynamic therapy (PDT) is a photoresponsive cancer therapy based on photosensitizers to generate reactive oxygen species (ROS) to eradicate tumor cells.

Additively Manufactured Flexible EGaIn Sensor for Dynamic Detection and Sensing on Ultra-Curved Surfaces.

Electronic skin is widely employed in multiple applications such as health monitoring, robot tactile perception, and bionic prosthetics. In this study, we fabricated millimeter-scale electronic skin featuring compact sensing units using the Boston Micro Fabrication S130 (a high-precision additive manufacturing device) and the template removal method. We used a gallium-based liquid metal and achieved an inner channel diameter of 0.

Study on Fire Temperature Field in Small-Section Steel-Shell Concrete Immersed Tube Tunnel Structure Based on CFD-FEM Method.

Small-section steel-shell concrete immersed tube tunnels are intended for minibuses and have a low fire heat release rate. Standard fire rise curves do not apply to such tunnels. In this study, a coupled method of computational fluid dynamics (CFD) and the finite element method (FEM) was used to simulate the structural temperature distribution in tunnels.

Assessing the use of the Index of Consciousness (IoC) as a monitoring tool for the sedative effects of ciprofol during general anesthesia induction: a prospective observational study.

Background: We investigated the consistency and accuracy of the Index of Consciousness (IoC) and the Bispectral Index (BIS) in monitoring the sedative effect of ciprofol during the induction of general anesthesia. There is extensive literature that reports good consistency and correlations between the IoC1 and the BIS in reflecting the sedation levels induced by propofol and sevoflurane but not by ciprofol.

Objective: The aim was to compare the consistency and accuracy of the IoC and BIS in monitoring the sedative effect of ciprofol during the induction of general anesthesia.

Carbon-based electrocatalytic dual-membrane system bolsters singlet oxygen production for ultrafast water decontamination.

Reactive electrochemical membranes (REMs) are promising technologies in treating pharmaceuticals and personal care products (PPCPs) in water. Herein, a novel carbon-based electrocatalytic dual-membrane system was designed to exploit the whole redox process of electrodes, in which the membrane cathode and anode were formed by carbon fibers doped with Fe and metal organic frameworks derived SnO, respectively. Propranolol (PRO) was used as a representative of PPCPs.

Enhanced stability of the NbO and NbO clusters: the π rule superatomic nature.

This study examines the chemical reactivity of niobium clusters with carbon dioxide (CO), with an emphasis on the analysis of the ensuing products NbO and NbO, which show up in the cationic and anionic mass spectra, respectively. Using density functional theory (DFT) calculations, we demonstrate the reactivity of the Nb clusters with CO and reveal distinct stabilization mechanisms for the two prominent products. The stability of NbO is determined by the existence of ten π bonds pertaining to π-electron delocalization, which conforms to the π electron configuration model.

Static Organic p-n Junctions in Photoelectrodes for Solar Ammonia Production with 86 % Internal Quantum Efficiency.

For photoelectrocatalytic cells, a limitation exists in finding appropriate photoelectrode configurations that couple efficient extraction of high-energy electrons from absorbed photons and selective catalysis. Here we report an organic p-n junction approach to fabricate molecular photoelectrodes for conversion of solar energy and nitrate into valuable ammonia product. Solar irradiation of the photoelectrode generates charge-separated states with electrons and holes spatially separated at the n-type and p-type components, as revealed by surface photovoltage mapping, at a quantum yield of 90 %.

BioBricks.ai: A Versioned Data Registry for Life Sciences Data Assets.

Researchers in biomedical research, public health and the life sciences often spend weeks or months discovering, accessing, curating, and integrating data from disparate sources, significantly delaying the onset of actual analysis and innovation. Instead of countless developers creating redundant and inconsistent data pipelines, BioBricks.ai offers a centralized data repository and a suite of developer-friendly tools to simplify access to scientific data.

Dimensional regulation of lanthanide metal-organic frameworks and their application in bacterial detection.

Low-dimensional (LD) lanthanide metal-organic frameworks (Ln-MOFs) have attracted considerable attention in different fields due to their exceptional optical properties and numerous accessible active sites. Through the dimensional regulation effect of dipicolinic acid (DPA), a new LD Ln-MOF crystal is synthesized to monitor nitroreductase (NTR) activity in living bacteria.

Regulating Arrhenius Activation Energy and Fluorescence Quantum Yields of AuNCs-MOF to Achieve High Temperature Sensitivity in a Wide Response Window.

Luminescent thermometry affords remote measurement of temperature and shows huge potential in future technology beyond those possible with traditional methods. Strategies of temperature measurement aiming to increase thermal sensitivity in a wide temperature response window would represent a pivotal step forward, but most thermometers cannot do both of them. Herein, we propose a balancing strategy to achieve a trade-off between high Arrhenius activation energy (), which could stretch the temperature response windows, and fluorescence quantum yields (QYs) in a manner that will increase thermal sensitivity in a wide response window.

Efficacy and safety of anti-programmed death-1 antibody-based combination therapy in advanced or metastatic gastric or gastroesophageal junction cancer in Chinese patients: A real-world study.

Purpose: Programmed death-1 antibody plus chemotherapy has gained approval for the treatment for (human epidermal growth factor receptor 2 negative locally advanced or metastatic gastric or gastroesophageal junction cancer. This study aims to analyze the efficacy and safety of anti-programmed death-1 antibody combined with chemo- or anti-angiogenesis therapy in Chinese patients with advanced or metastatic gastric or gastroesophageal junction cancer in a real-world setting.

Methods: In total, 122 patients treated with anti-programmed death-1 antibody-based combination therapy between April 2019 and December 2021 were encompassed.

Chidamide induces cell cycle arrest via NR4A3/P21 axis upregulation to suppress relapsed and refractory acute myeloid leukemia.

Unlabelled: (1) Currently, the survival prognosis for patients with relapsed and refractory acute myeloid leukemia (R/R AML) is extremely poor. Therefore, the exploration of novel drugs is imperative to enhance the prognosis of patients with R/R AML. The therapeutic efficacy and mechanism of Chidamide, a novel epigenetic regulatory drug, in the treatment of R/R AML remain unclear.