Publications by authors named "Yifa Yin"
Article Synopsis
- Cancer is a significant public health issue in China, with rising rates of incidence and mortality, particularly concerning concurrent cancers defined as having multiple primary malignancies in an individual.
- A Chinese family with several concurrent cancer cases was studied using whole exome sequencing to identify genetic mutations that could explain their conditions.
- The analysis highlighted the NADH:ubiquinone oxidoreductase core subunit S7 as a candidate gene for somatic mutations and identified 16 other genes with germline mutations, providing new insights into the molecular causes of concurrent cancers.
Objective: This present study is performed to figure out the role of microRNA-136 (miR-136) in radiosensitivity of esophageal squamous cell carcinoma (ESCC) cells through the regulation of MUC1.
Methods: Seventy-four ESCC patients were divided into radiotherapy sensitive group and radiotherapy resistance group. Colony formation assay and flow cytometry were used to test the radiosensitivity of radiotherapy resistant strain and parent strain.
Fascin actin-bundling protein 1 (FSCN1) plays significant roles in biological processes such as tumor cell invasion and metastasis. However, little is known about prognostic value of FSCN1 in non-small cell lung cancer (NSCLC). FSCN1 mRNA and protein expression were detected by real-time PCR and Western blot in NSCLC tissues and paired adjacent normal lung tissues.
View Article and Find Full Text PDFComplete sequence of a cholangiocarcinoma inbred Sprague-Dawley rat model mitochondrial genome.
Mitochondrial DNA A DNA Mapp Seq Anal
May 2016
In the present work we undertook the complete mitochondrial genome sequencing of an important cholangiocarcinoma model inbred rat strain for the first time. Its mitogenome was 16,312 bp and coding 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes. A total of 96 SNPs were examined when compared to reference BN sequence.
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