Publications by authors named "Yidong Liu"

This study pioneers a molecular topology engineering strategy by incorporating a twisted diamine motif into polyimide (PI) backbones, achieving an unprecedented integration of thermal stability, mechanical robustness, and optoelectronic functionality that surpasses conventional high-performance PIs. Unlike traditional PIs constrained by performance trade-offs (e.g.

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This study addresses the limitations of traditional polyimides (PIs) in high-frequency and high-temperature soft electronic applications, and then introducing trifluoromethylbenzene (TFMB) into the molecular structure and employing various diamines as connecting components to solve the bottleneck. The innovative molecular design enhances thermal, mechanical, and dielectric properties, overcoming challenges in balancing these performances. The optimized fluorinated PI (TPPI50) exhibits exceptional properties, including a glass transition temperature of 402 °C, thermal decomposition temperature of 563 °C, tensile strength of 232.

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Background: D-2-hydroxyglutarate (D-2HG), an oncometabolite derived from the tricarboxylic acid cycle. Previous studies have reported the diverse effects of D-2HG in pathophysiological processes, yet its role in breast cancer remains largely unexplored.

Methods: We applied an advanced biosensor approach to detect the D-2HG levels in breast cancer samples.

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Prokaryotic Argonaute proteins (pAgos) defend the host against invading nucleic acids, including plasmids and viruses. Short pAgo systems confer immunity by inducing cell death upon detecting invading nucleic acids. However, the activation mechanism of the SiAgo system, comprising a short pAgo from the archaeon Sulfolobus islandicus and its associated proteins SiAga1 and SiAga2, remains largely unknown.

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Purpose: Severe combined immunodeficiency (SCID) is a set of rare monogenic inherited diseases that together represent the most severe form of the primary immunodeficiency disease phenotype. Preimplantation genetic testing for monogenic defects (PGT-M) is an effective reproductive technology strategy to prevent disease-causing gene mutations from being transmitted to offspring. The aim of this study was to report the use of PGT-M strategy based on karyomapping in four families to avoid the birth of SCID children.

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Sulfone motifs play important roles in bioactive compounds and functional materials. The development of efficient methodologies for constructing sulfonyl-containing compounds has thus attracted considerable attention. Here, we introduce a protocol for the preparation of alkyl aryl sulfones under mild conditions.

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Background: Chromosome abnormalities are a leading cause of conception failure and pregnancy loss. While traditional cytogenetics technologies like karyotyping have been helpful in identifying structural variations (SVs), they face challenges in detecting complex rearrangements and cryptic structures. In this study, we developed a new method called chromosome conformation based karyotyping (C-MoKa) to comprehensively detect different types of chromosomal abnormalities in patients with conception failure and pregnancy loss.

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Article Synopsis
  • The study focuses on creating unique eight-membered rings within tetraphenylene derivatives using a method called [4+4] cycloaddition, which has been challenging until now.
  • The researchers successfully performed a stereoselective cross-[4+4] cycloaddition of quinone methides (QMs), resulting in new oxa-analogues of tetraphenylene that demonstrate high selectivity and stability.
  • This work not only broadens the range of chiral medium-sized rings available but also enhances the understanding and application of asymmetric cycloadditions in chemistry.
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Background: Acetate is an important chemical feedstock widely applied in the food, chemical and textile industries. It is now mainly produced from petrochemical materials through chemical processes. Conversion of lignocellulose biomass to acetate by biotechnological pathways is both environmentally beneficial and cost-effective.

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Secondary amines are widely used as robust catalysts for the enantioselective functionalization of aldehydes, yet they are rarely employed as Lewis bases or hydrogen-bonding catalysts for alkene activation. In this study, we present a decarboxylative [4 + 2] cycloaddition of vinyl benzoxazinanones with nitroolefins to construct tetrahydroquinolines through cascade catalysis. A single chiral morpholine catalyst sequentially functions as both a Lewis base and a hydrogen-bonding catalyst.

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Article Synopsis
  • Researchers created a variety of fused tricyclic heterocycles using a process involving the dimerization and cyclization of benzene derivatives when exposed to visible light.
  • The process is initiated by aryloxy radicals formed through a reaction involving proton-coupled electron transfer from a photoexcited vinylidene-quinone methide (VQM) and a Brønsted base.
  • This method highlights the innovative use of light and unique chemical reactions to synthesize complex compounds.
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Article Synopsis
  • Whey is a by-product of the dairy industry with potential pollutant concerns, but it can be fermented to produce valuable chemicals like α-ketoisovalerate.
  • The study used a modified strain of Klebsiella oxytoca (KIV-7) to efficiently produce α-ketoisovalerate by inactivating certain enzymes and overexpressing others, achieving high yields from both lactose and whey powder.
  • The findings suggest that K. oxytoca KIV-7, with integrated genes for α-ketoisovalerate production, can be a stable and effective option for generating this chemical and its derivatives.
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Article Synopsis
  • The study introduces a unique enantioselective intramolecular Diels-Alder (IMDA) reaction using a specific compound called vinyl branched vinylidene-quinone methide (VQM).
  • This reaction is notable for its ability to control site selectivity, resulting in the formation of chiral bridged bicyclic structures.
  • The yields of these products are impressive, reaching as high as 85%, with enantioselectivities reported at an exceptional 97% ee.
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l-2-Hydroxyglutarate (l-2-HG) is a functionally compartmentalized metabolite involved in various physiological processes. However, its subcellular distribution and mitochondrial transport remain unclear owing to technical limitations. In the present study, an ultrasensitive l-2-HG biosensor, sfLHGFR, composed of circularly permuted yellow fluorescent protein and l-2-HG-specific transcriptional regulator, is developed.

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Background: Disheveled, EGL-10, and pleckstrin (DEP) domain-containing protein 5 (DEPDC5) is a component of GTPase-activating protein (GAP) activity toward the RAG complex 1 (GATOR1) protein, which is an inhibitor of the amino acid-sensing branch of the mammalian target of rapamycin complex 1 (mTORC1) pathway. GATOR1 complex variations were reported to correlate with familial focal epilepsy with variable foci (FFEVF). With the wide application of whole exome sequencing (WES), more and more variations in were uncovered in FFEVF families.

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Objective: To evaluate the effect of a new strategy of transperineal anastomotic urethroplasty (TAU) with proximal transection in treating pelvic fracture urethral injury (PFUI) associated with urethrorectal fistula (URF).

Patients And Methods: A retrospective review of all patients treated by TAU with proximal transection and fistula repair for PFUI associated with URF was performed between August 2013 and July 2022. Information on demographics, peri-operative variables, and postoperative follow-up outcomes was collected.

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Objectives: To assess the effect of redo inferior pubectomy on the management of complicated pelvic fracture urethral injury (PFUI) in patients with a history of failed anastomotic urethroplasty.

Materials And Methods: We retrospectively reviewed all patients receiving redo anastomotic urethroplasty with redo inferior pubectomy for failed PFUI between January 2010 and December 2021. Patients with incomplete data and those who were lost to follow-up were excluded.

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Background: The traditional audiovisual sexual stimulation (AVSS) test may experience limitations including low erectile response rate and lack of unified diagnostic criteria.

Aim: We aimed to explore the clinical value of AVSS with virtual reality (VR-AVSS) test in assessing erectile function and diagnosing erectile dysfunction (ED).

Methods: Participants 18 to 60 years of age were screened for analysis in 3 clinical centers from June 2020 to March 2022.

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Steroid hybrids have emerged as a type of advantageous compound as they could offer improved pharmacological and pharmaceutical properties. Here, we report a series of novel peptide-dehydroepiandrosterone hybrids, which would effectively induce endoplasmic reticulum stress (ERS) and lead to apoptosis with outstanding in vitro and in vivo anti-melanoma effects. The lead compound IId among various steroids conjugated with peptides and pyridines showed effective in vivo activity in B16 xenograft mice: in medium- and high-dose treatment groups (60 and 80 mg/kg), compound IId would significantly inhibit the growth of tumours by 98%-99% compared to the control group, with the highest survival rate as well.

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The conventional orthogonality of Laguerre-Gaussian (LG) beams is widely recognized and serves as the fundamental basis for mode division multiplexing utilizing LG beams as channels. However, this conventional orthogonality holds true only when two LG beams share the same axis. Whether non-coaxial LG beams, with parallel axes separated by a distance, are orthogonal to each other remains an open question.

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L-Valine, a branched-chain amino acid with diversified applications, is biosynthesized with α-acetolactate as the key precursor. In this study, the metabolic flux in Klebsiella oxytoca PDL-K5, a Risk Group 1 organism producing 2,3-butanediol as the major fermentation product, was rearranged to L-valine production by introducing exogenous L-valine biosynthesis pathway and blocking endogenous 2,3-butanediol generation at the metabolic branch point α-acetolactate. After further enhancing L-valine efflux, strengthening pyruvate polymerization and selecting of key enzymes for L-valine synthesis, a plasmid-free K.

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Photoresponsive materials enable dynamic remote control of their fundamental properties. The incorporation of photochromic molecules in nanoporous metal-organic frameworks (MOFs) provides a unique opportunity to tailor the material properties, including the interaction between the MOF host and guest molecules in the pores. Here, a MOF film of type HKUST-1 with embedded hexaarylbiimidazole (HABI), undergoing reversible light-induced reactions between the stable dimer state and the metastable radical state, is presented.

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l-2-Hydroxyglutarate (l-2-HG) is a critical signaling and immune metabolite but its excessive accumulation can lead to l-2-hydroxyglutaric aciduria, renal cancer, and other diseases. Development of efficient and high-throughput methods for selective l-2-HG detection is urgently required. In this study, l-2-HG dehydrogenase in Azoarcus olearius BH72 (AoL2HGDH) was screened from ten homologs and identified as an enzyme with high specificity and activity toward l-2-HG dehydrogenation.

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Background: Haploid embryonic stem cells (haESCs) have been established in many species. Differentiated haploid cell line types in mammals are lacking due to spontaneous diploidization during differentiation that compromises lineage-specific screens.

Aim: To derive human haploid neural stem cells (haNSCs) to carry out lineage-specific screens.

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The catalytic dearomative cycloaddition of bicyclic heteroaromatics including benzofurans and indoles provides rapid access to functionalized heterocyclic molecules. Because of the inherent stereoelectronic differences, the furan or pyrrole nucleus is more prone to dearomative cycloaddition than the benzene ring. Here, we realized a geometry-based differentiation approach for achieving C6-C7 and C7-C7a regioselectivity.

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