Publications by authors named "Yidie Zou"
Mycobacterial infection poses a significant threat to human health, with granuloma formation serving as a hallmark pathological feature and a critical diagnostic indicator. Langhans giant cells (LGCs) play a pivotal role in the immune response during mycobacterial infections, yet their immunological functions remain incompletely understood. In this study, we explored the role of LGCs in immune modulation during mycobacterial infection.
View Article and Find Full Text PDFBackground: Cutaneous Mycobacterium marinum (M. marinum) infection can lead to the formation of infectious granulomas containing Langhans giant cells (LGCs). Due to concerns about prolonged antibiotic use and the development of drug resistance, its treatment poses challenges.
View Article and Find Full Text PDFReview of research progress on different modalities of Macrophage death in Mycobacterium leprae infection.
Int Immunopharmacol
December 2024
Article Synopsis
- Leprosy is a chronic infectious disease caused by the bacterium Mycobacterium leprae, mainly affecting the skin and nerves, with macrophages being the key host cells involved in its progression.
- The review discusses different types of macrophage cell death caused by M. leprae, including apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, and necrosis, and their effects on the immune response.
- It highlights that apoptosis and autophagy may help control M. leprae growth, while necroptosis and pyroptosis enhance inflammation, and new findings show that ferroptosis helps infected macrophages escape immune detection by polarizing towards a less aggressive M2 state.