Publications by authors named "Yidie Ying"
Investigating the Shared Genetic Architecture Between Leukocyte Telomere Length and Prostate Cancer.
World J Mens Health
September 2024
Article Synopsis
- - Evidence suggests a genetic link between leukocyte telomere length (LTL) and prostate cancer (PCa), with a global genetic correlation found (0.066, p=0.017) and significant loci identified through cross-trait GWAS.
- - The study discovered 44 shared genetic loci, including two new single nucleotide polymorphisms, and significant shared genetic enrichment in the small intestine, which may influence both LTL and PCa.
- - Findings support the idea that longer LTL may increase PCa risk, highlighting the potential for developing new therapeutic targets and strategies for predicting risk in future research.
Article Synopsis
- The study developed explainable machine learning models to predict overall survival for patients with retroperitoneal liposarcoma, focusing on enhancing transparency in results.!
- Data was collected from the SEER database and an external cohort, and six machine learning models were created using various statistical analysis techniques to identify risk factors influencing survival rates.!
- Key factors included patient demographics and tumor characteristics, with the ranger model demonstrating the best predictive performance across training and validation datasets.!
Article Synopsis
- Adrenocortical carcinoma (ACC) is a rare and aggressive cancer, and there is currently no reliable way to predict patient survival rates.
- Researchers developed a nomogram and risk classification system based on clinicopathological data from ACC patients to forecast overall survival at 1, 3, and 5 years.
- The final nomogram included age and tumor characteristics, showed effective predictive capabilities, and indicated significant differences in median survival between low-risk (70 months) and high-risk (10 months) groups.
Cisplatin-containing combination chemotherapy has been used as the standard treatment for bladder cancer patients at advanced stage. However, nearly 50% of patients are nonresponders. To guide the selection of more effective chemotherapeutic agents, a bladder cancer spheroids microfluidic drug sensitivity analysis system was established in this study.
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- Digital rectal examination (DRE) is a traditional, low-cost method for detecting prostate cancer, but its necessity has come into question with the rise of prostate-specific antigen (PSA) testing.
- In a study involving 597 patients suspected of having prostate cancer who were referred for biopsy, DRE showed a diagnostic accuracy of 63.45%, with higher effectiveness for detecting tumors in the peripheral zone compared to other zones.
- DRE results were notably associated with higher Gleason scores, indicating more aggressive cancer, suggesting it can assist doctors in assessing the need for biopsies in patients with elevated PSA levels.
Article Synopsis
- Transposable elements (TEs) can act as ectopic promoters that trigger the expression of oncogenes, a process known as onco-exaptation, which is frequently observed in various cancers, particularly bladder cancer.
- In a study analyzing 137 RNA-seq datasets from six cohorts, 44 specific onco-exaptation events were identified in bladder cancer cell lines, with the L1PA2 element being the most involved.
- Among these events, L1PA2-SYT1 not only showed a strong presence in cancer samples but was also linked to increased tumor invasiveness and worse patient survival, highlighting its potential as a key factor in bladder cancer progression.
Article Synopsis
- The study investigates the role of lymphovascular invasion (LVI) in selecting patients with muscle-invasive bladder cancer (MIBC) for neoadjuvant chemotherapy (NAC) before radical cystectomy (RC).
- Two cohorts from Lund University were analyzed, revealing that patients with positive LVI in transurethral resection (TUR) specimens had a significantly higher 3-year cancer-specific survival benefit (26.2%) from NAC compared to those without LVI.
- The findings suggest that assessing LVI could help identify patients who would benefit most from NAC, but further research is needed for validation.
Article Synopsis
- - This study aimed to establish a causal relationship between total testosterone (TT) and bioavailable testosterone (BT) levels and cancer risk in women, addressing previous inconclusive findings in observational research.
- - Using a Mendelian randomization approach, researchers analyzed genetic data and employed multiple statistical methods to assess the link between testosterone and various cancers, with emphasis on reliability through sensitivity analyses.
- - Results indicated a positive association between BT and the risk of breast and endometrial cancers, while TT was linked to increased risks for breast, cervical, and endometrial cancers; notably, there was a negative correlation between BT and ovarian cancer risk.
Article Synopsis
- PKMYT1 is found to be upregulated in bladder cancer (BLCA) and is linked to worse patient outcomes, indicating its potential role in tumor progression.
- Reducing PKMYT1 expression inhibits BLCA cell growth, migration, and invasion, while also promoting cell death.
- The expression of PKMYT1 is regulated by the proteins YAP and TEAD1, suggesting that targeting this pathway may offer new treatment options for bladder cancer.
Purpose: Urothelial carcinomas (UCs) are often characterized by frequent recurrences after surgery, making UC one of the costliest cancers. Chromosomal instability (CIN) has been proven to be a hallmark of UCs and is related to the prognosis of many cancer types. In this study, we evaluated CIN of urine sediments as a prognostic indicator for UCs.
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- KIF4A is found to be overexpressed in urothelial bladder carcinoma (UBC) compared to noncancerous tissues, linking high levels of KIF4A to poorer patient survival outcomes.
- Experiments showed that reducing KIF4A levels in UBC cells led to decreased cell proliferation, migration, and invasion while increasing apoptosis, suggesting a critical role in cancer progression.
- The study also identified a relationship between KIF4A and YAP1, where changes in KIF4A expression influenced YAP1 activity and localization, indicating potential pathways for therapeutic intervention.
Background: Currently, the treatment regimen of bladder cancer depends on the stage and grade. Yet, patients with similar histopathological characteristics may have distinct prognosis. Luminal/basal subtyping had proved to be a satisfactory subtyping method.
View Article and Find Full Text PDFFatty acid metabolism (FAM) genes are potentially useful for predicting prognosis and immunotherapy response in bladder cancer (BC). To examine this, we constructed a prognostic model and identified key FAM genes in BC. Using transcriptional expression profiles and clinical data of BC patients from public datasets and Changhai (CH) hospital, we built and validated a risk-score model based on 13 prognostic FAM genes.
View Article and Find Full Text PDFBackground: Currently, the impact of previous, simultaneous, or subsequent bladder cancer on the prognosis of upper urinary tract urothelial carcinoma (UTUC) is controversial. We aimed to investigate the impact of previous, simultaneous or intravesical recurrence (IVR) bladder cancer on the prognosis of UTUC based on a large population-based cohort from the Surveillance, Epidemiology, and End Results (SEER) database.
Methods: A total of 8,431 UTUC patients diagnosed from 2004 to 2018 met the inclusion criteria were identified based on the SEER database.
Background: Urachal cancer is a rare neoplasm in the urological system. To our knowledge, no published study has explored to establish a model for predicting the prognosis of urachal cancer. The present study aims to develop and validate nomograms for predicting the prognosis of urachal cancer based on clinicopathological parameters.
View Article and Find Full Text PDFPurpose: Urothelial carcinoma is a malignant cancer with frequent chromosomal aberrations. Here, we investigated the application of a cost-effective, low-coverage whole-genome sequencing technology in detecting all chromosomal aberrations.
Experimental Design: Patients with urothelial carcinomas and nontumor controls were prospectively recruited in clinical trial NCT03998371.
Cisplatin-based chemotherapy is the first-line treatment for patients with advanced bladder cancer. However, as more than 50% of patients are ineligible for cisplatin-based chemotherapy, there is an urgent need to develop new drugs. Cuprous oxide nanoparticles (CONPs), as a new nano-therapeutic agent, have been proved to be effective in many kinds of tumors.
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