N-acetylcysteine and chitosan conjugate modified dexamethasone nanostructured lipid carriers: Enhanced permeability, precorneal retention and lower inflammation for the treatment of dry eye syndrome.

Dexamethasone (Dex) is a primary medication for treating dry eye syndrome, and tobramycin-dexamethasone eye drops are commercially available. However, the eye's complex physiological environment reduces its bioavailability, and repeated use can lead to significant systemic toxicity and side effects. This study introduces a novel conjugate of chitosan (CS) and N-acetylcysteine (NAC), a bioadhesive material, which was grafted onto the surface of a Dex-supported nanostructured lipid carrier (NLC) to develop an innovative nanoparticle lipid ocular drug delivery system (CS-NAC@Dex-NLC).

Synergistic mechanism of stir-baked curcumae radix with vinegar in dysmenorrhea rats based on UPLC-Q-TOF/MS metabolomics.

Curcumae Radix (i.e. Huangsiyujin: HSYJ), a well-known traditional Chinese medicine (TCM), has been widely used in clinical practice for many years to treat depression and primary dysmenorrhea.

Baseline Interleukin-6 and Erythrocyte Sedimentation Rate Can Predict Clinical Response of TNF Inhibitor Treatment in Patients with Ankylosing Spondylitis.

Objective: The objective of this study is to investigate the baseline predictors of clinical response from tumor necrosis factor (TNF) inhibitor within ankylosing spondylitis (AS) patients.

Methods: We selected 60 AS patients and 24 healthy individuals. The interleukin (IL)-1β, IL-6, IL-17A and TNF-α levels were measured using the cytometric bead array.

Effective serum level of etanercept biosimilar and effect of antidrug antibodies on drug levels and clinical efficacy in Chinese patients with ankylosing spondylitis.

Objectives: To investigate the effective serum level of etanercept biosimilar in Chinese patients with ankylosing spondylitis (AS) who achieve AS Disease Activity Score-C-reactive protein (ASDAS-CRP) < 2.1, and the effect of antidrug antibodies on drug levels and clinical efficacy.

Methods: Our study enrolled 60 patients with AS who were treated with etanercept biosimilar.

[Clinical features and disease activity index of Behçet's disease].

Objective: The clinical features and two disease activity assessment methods of Behçet's disease were evaluated in order to guide clinical management.

Methods: A total of 116 patients with Behçet's disease from China-Japan Union Hospital of Jilin University in 2007-2014 were analyzed retrospectively for the gender and age distribution as well as clinical features of multisystem involvement. The correlations of Behçet's Disease Current Activity Form (BDCAF) and electronic medical record (EMR)-based activity index (EMRAI) scoring systems with clinical data were compared in Chinese patients for the first time, and clinical suggestion was raised.

A morphologic study of the transcallosal-interventricular foramen approach in endoscopic third ventriculostomy with magnetic resonance imaging.

There is a very wide range of applications in neurosurgery for the treatment of obstructive hydrocephalus by third ventriculostomy. To facilitate the operation, we measured the related data of transcallosal-interventricular foramen approach in endoscopic third ventriculostomy with the magnetic resonance images of the third ventricle from 103 healthy adults. We calculated the mean and standard deviation as well as the 95% confidence interval for the mean value of the measured data, which conformed to normal distribution.

Morphological study of surgical approach by superior temporal sulcus-temporal horn of lateral ventricle approach using volume rendering.

In this research, we acquired the length of the superior temporal sulcus, the shortest distance from the superior temporal sulcus to the temporal horn of the lateral ventricle, and the approach angle between the median sagittal plane and the shortest segment from the superior temporal sulcus to the temporal horn of the lateral ventricle measuring 98 specimens by magnetic resonance imaging volume rendering. At the same time, we preliminarily oriented the point of the superior temporal sulcus, which is closest to the temporal horn of the lateral ventricle, aimed at finding out the best entrance point of surgical approach through the superior temporal sulcus to the temporal horn of the lateral ventricle and reducing the damage to optic radiation as well as other nerve fibers during the operation. The results indicate that the point at the front side 3/5 of the superior temporal sulcus may be the ideal surgical approach entrance point, and there is no difference between 2 cerebral hemispheres (P < 0.

Investigation of organic pollutants in wastewater-irrigated soil and its DNA damage and oxidative damage on mice.

This work aimed to determine the DNA and oxidative damage on mice by mixtures of organic contaminants in wastewater-irrigated soil, in order to assess their usefulness as markers for this kind of pollution. Wastewater-irrigated soil samples in the vicinity of an industrial area in Tangshan, China were collected, and soil irrigated by underground water satisfying drinking water standards was used as control group. Organic pollutants were extracted from the soil using ultrasonic oscillation, and analyzed by gas chromatography-mass spectrometry (GC-MS).