Spatial and temporal variability of physicochemical characteristics in Lancang River sediments amid hydropower development.

The construction of river dams disrupts river continuity and sediment transport, altering the riverbed between sediment "sources" and "sinks" and changing the sediment characteristics of the river. In this study, 256 sediment samples from 54 major control cross-sections of the Lancang River (LCR) were analyzed to examine the spatial and temporal distribution of clay and non-clay minerals in the sediment and their relationship with the environmental changes caused by the construction 11 hydropower plants. The results indicate that the construction of terrace dams on the LCR interrupted the downstream refinement trend of sediments, which reappeared once the terrace reservoirs stabilized.

Serum microRNA-181a Expression Level in Patients with Acute Liver Failure and Its Correlation with Prognosis.

Objective: This paper examined miR-181a expression in the serum of patients with acute liver failure (ALF) and investigated the impact of its expression in the prognosis of ALF patients.

Methods: A total of 112 ALF patients (ALF group) and 100 healthy controls during the same period (control group) were recruited as study subjects, and ALF patients were separated into the survival group and the death group. Serum ALT, AST, SCr, TBil, PTA, and International Normalized Ratio (INR) indices as well as serum miR-181a expression were assessed by using a fully automated biochemistry analyzer and RT-qPCR.

Dynamic Evolution of Land Use/Land Cover and Its Socioeconomic Driving Forces in Wuhan, China.

Human activities are considered as the main driving forces of land use/land cover (LULC) variation at city scales. Monitoring the dynamic variation of LULC and its socioeconomic driving forces helps to reveal the response of LULC change to human activities and land use policies. However, this issue remains poorly understood.

Multidisciplinary management of pediatric malignant rhabdoid tumor based on 5 years of experience at a tertiary care center.

Objective: Malignant rhabdoid tumor (MRT) is a highly aggressive tumor that occurs mostly in young children with extremely poor prognosis. Standardized and effective treatment strategies for MRT have yet to be established because of its rarity. Here, we report our single-institutional experience involving MRT treatment.

Treatment of infantile fibrosarcoma: A tertiary care center experience.

Objective: Infantile fibrosarcoma (IFS) is a highly locally aggressive nonrhabdomyosarcomatous soft tissue sarcoma that most commonly occurs in young infants. There exists no standard treatment this lesion due to its rarity. We shared our treatment experience for IFS in this study.

Treatment of Pediatric Inflammatory Myofibroblastic Tumor: The Experience from China Children's Medical Center.

Background: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor with intermediate malignancy that tends to affect children primarily. To date, no standardized therapies exist for the treatment of IMT. This study aimed to share experience from China Children's Medical Center for the explorative treatment of IMT.

Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice.

To investigate the protective effects of celastrol on mice with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), and to explore its underlying mechanism. The levels of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) in serum were tested. Malondialdehyde (MDA) and superoxide dismutase (SOD), GOT, and GPT in serum were also detected.

STAT3-induced upregulation of lncRNA CASC11 promotes the cell migration, invasion and epithelial-mesenchymal transition in hepatocellular carcinoma by epigenetically silencing PTEN and activating PI3K/AKT signaling pathway.

Accumulating evidence suggest that long noncoding RNAs (lncRNAs) are dysregulated in various tumors and serve as crucial regulators in biological processes. Based on The Cancer Genome Atlas (TCGA) database, upregulation of CASC11 was associated with the low overall survival rate of patients with Hepatocellular carcinoma (HCC). However, the function and mechanism of lncRNA CASC11 in the progression of HCC remain unclear.

MicroRNA‑34a inhibits liver cancer cell growth by reprogramming glucose metabolism.

MicroRNAs (miRs) have been proposed as minimally invasive prognostic markers for various types of cancer, including liver cancer, which is one of the most common cancers worldwide. In the present study, the expression of miR‑34a in human liver cancer tissues and cell lines was evaluated and the effects of miR‑34a on cell proliferation, invasion and glycolysis in hepatocellular carcinoma (HCC) cells were determined. The results indicated that miR‑34a was downregulated in human liver cancer tissues.

LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma.

Background: Recent findings have identified thousands of long non-coding RNAs (lncRNAs) and reveal that lncRNAs play crucial roles in the regulation of tumor development and progression. However, the clinical significance and potentially functional value of LINC00261 in hepatocellular carcinoma (HCC) remain unknown.

Methods: Expression of LINC00261 was detected by qRT-PCR in HCC tissues and adjacent normal tissues.