GABA regulates the proliferation and apoptosis of head and neck squamous cell carcinoma cells by promoting the expression of CCND2 and BCL2L1.

Gamma-aminobutyric acid (GABA) is a multifunctional molecule that is widely present in the nervous system and nonneuronal tissues. It plays pivotal roles in neurotransmission, regulation of secretion, cell differentiation, proliferation, and tumorigenesis. However, the exact mechanisms of GABA in head and neck squamous cell carcinomas (HNSCCs) are unknown.

Enucleation combined with peripheral ostectomy: its role in the management of large cystic ameloblastomas of the mandible.

Aim: Aggressive resection of a large mandibular cystic ameloblastoma may cause severe deformity and dysfunction, while simple enucleation may carry a high risk of recurrence. The purpose of this study was to evaluate, in terms of both recurrence and the preservation of contour and function, the effectiveness of enucleation combined with peripheral ostectomy (Enu/PO) in managing large mandibular cystic ameloblastomas.

Materials And Methods: Fourteen patients who had large mandibular cystic ameloblastoma (11 unicystic, 3 multicystic) and had been treated with the Enu/PO were reviewed.

[Application of computer aided design-computer aided manufacture technique in mandible defect reconstruction with individual titanium prosthesis].

Objective: To investigate the application of computer aided design-computer aided manufacture (CAD-CAM) technique in the reconstruction of mandible defect with individual titanium prosthesis.

Methods: Six patients with large mandibular ramus and angle tumor were spiral CT scanned preoperatively, and the CAD-CAM was used to design and make individual titanium prosthesis for reconstructing the mandibular defects after resection of the tumor. The prosthesis were assembled during operation.

[Application of three dimensional model in evaluating the effect of artificial bone implantation of hard cleft palate on the development of maxilla].

Objective: To observe the effect of artificial bone implantation of hard cleft palate on the development of maxilla.

Methods: From January 1997 to December 1999, 40 patients with hard cleft palate were randomly divided into two groups: control group and implantation group (n = 20 each). The patients in the implantation group received an implantation of compound artificial bone of HA-Bone cement.

[Soft tissue profile changes in micrognathia after distraction osteogenesis].

Objective: To evaluate the effect of distraction osteogenesis for severe micrognathia by comparing the pre- and post-operative profile and mentolabial relationship.

Methods: 16 cases underwent temporal-mandibular joint plasty and temporal fasciomuscular flap transfer. The mandibular distraction began at the 5th postoperative day at a rate of 0.