An NIR-II-emitting type-I photosensitizer for efficient hypoxic tumor phototheranostics.

A small molecule-based NIR-II type-I photosensitizer (IT-IC) with a strong push-pull effect and good planar π-conjugated structure was synthesized. The IT-IC NPs exhibited strong light absorption, outstanding NIR-II fluorescence emission, excellent photothermal conversion and efficient type-I/II ROS generation, showing encouraging therapeutic outcomes for hypoxic tumors.

A diketopyrrolopyrrole-based small molecule with an extended conjugated skeleton and J-aggregation behavior for 808 nm laser triggered phototheranostics.

The development of phototheranostic agents, specifically those based on organic small molecules (OSMs) with long wavelength excitation/emission, is an attractive but challenging project. In this contribution, we designed and synthesized a novel conjugate small molecule with a linear structure, named DPP-OPIC. Water-soluble nanoparticle DPP-OPIC NPs were fabricated.

Molecular Oligomerization and Donor Engineering Strategies for Achieving Superior NIR-II Fluorescence Imaging and Thermotherapy under 1064 nm Laser Irradiation.

An enormous challenge still exists for designing molecules with the second near-infrared (NIR-II, 1000-1700 nm) window absorption, NIR-II fluorescence emission, and batch-to-batch reproducibility, which is the premise for high-performance NIR-II phototheranostics. Although organic small molecules and polymers have been largely explored for phototheranostics, it is difficult to satisfy the above three elements simultaneously. In this work, molecular oligomerization (the general structure is S-D-A-D'-A-D-S) and donor engineering (changing the donor linker D') strategies are applied to design phototheranostic agents.

Design, fabrication and application of self-spiraling pattern-driven 4D-printed actuator.

Self-spiraling actuators are widely found in nature and have high research and actuator-application value in self-lock and self-assembly. Four-dimensional (4D) printing is a new generation additive manufacturing of smart materials and has shown great potential for the fabrication of multi-functional and customized structures. The microarchitecture design of a bilayer actuator could bring flexible and diversified self-spiraling behaviors and more possibilities for practical application by combing 4D printing.

Identification of the cDNA Encoding the Growth Hormone Receptor () and the Regulation of and Gene Expression by Nutritional Status in Reeves' Turtle ().

(Reeves' turtle) is a slow-growing reptile that is distributed widely across China. Prior to this study, the cDNA sequence of the growth hormone receptor () in the Reeve's turtle, or how periods of starvation might influence the gene expression of and insulin-like growth factor I () in this species, were unknown. Here, we identified the full-length sequence of the cDNA encoding GHR in Reeves' turtle by using RT-PCR and RACE.

Crashworthiness Optimization Design of Aluminum Alloy Thin-Walled Triangle Column Based on Bioinspired Strategy.

Aluminum alloy thin-walled structures have been well used in applications of energy absorption. In the present work, a bioinspired design strategy for aluminum alloy thin-walled structures is proposed to improve the performance of out-of-plane crashworthiness by altering the material distribution. According to the proposed strategy, a novel fractal thin-walled triangle column (FTTC) is designed, which is composed by iteratively applying the affine transformation of a base triangle up to 2nd-order.

A Robust Predicted Performance Analysis Approach for Data-Driven Product Development in the Industrial Internet of Things.

Industrial Internet of Things (IoT) is a ubiquitous network integrating various sensing technologies and communication technologies to provide intelligent information processing and smart control abilities for the manufacturing enterprises. The aim of applying industrial IoT is to assist manufacturers manage and optimize the entire product manufacturing process to improve product quality and production efficiency. Data-driven product development is considered as one of the critical application scenarios of industrial IoT, which is used to acquire the satisfied and robust design solution according to customer demands.

Excellent oxygen evolution reaction of NiO with a layered nanosphere structure as the cathode of lithium-oxygen batteries.

A layered nanosphere structured NiO catalyst was successfully synthesized by a simple and efficient hydrothermal method as a cathode material for lithium-oxygen (Li-O) batteries. Cyclic voltammetry (CV), dual electrode voltammetry (DECV) and chronoamperometry (CA) by rotating ring-disk electrode (RRDE) were carried out to investigate the catalytic activity of this catalyst for the oxygen evolution reaction (OER). The results revealed that the layered nanosphere NiO exhibited excellent electrochemical performance, stability and a typical four-electron reaction as a cathode electrocatalyst for rechargeable nonaqueous Li-O batteries.