AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy.

Background: Radiation (IR)-induced DNA damage triggers cell cycle arrest and has a suppressive effect on the tumor microenvironment (TME). Wee1, a cell cycle regulator, can eliminate G2/M arrest by phosphorylating cyclin-dependent kinase 1 (CDK1). Meanwhile, programed death-1/programed death ligand-1 (PD-1/PDL-1) blockade is closely related to TME.

Self-Assembled Ruddlesden-Popper/Perovskite Hybrid with Lattice-Oxygen Activation as a Superior Oxygen Evolution Electrocatalyst.

The oxygen evolution reaction (OER) is pivotal in multiple gas-involved energy conversion technologies, such as water splitting, rechargeable metal-air batteries, and CO /N electrolysis. Emerging anion-redox chemistry provides exciting opportunities for boosting catalytic activity, and thus mastering lattice-oxygen activation of metal oxides and identifying the origins are crucial for the development of advanced catalysts. Here, a strategy to activate surface lattice-oxygen sites for OER catalysis via constructing a Ruddlesden-Popper/perovskite hybrid, which is prepared by a facile one-pot self-assembly method, is developed.

An in situ assembled WO-TiO vertical heterojunction for enhanced Z-scheme photocatalytic activity.

The face-to-face contact of a vertical heterojunction is beneficial to charge interaction in photocatalysis. However, constructing a vertical heterojunction with uncompromised redox ability still remains a challenge. Herein, we report the successful synthesis of a WO3-TiO2 vertical heterojunction via establishing an internal electric field across the interface.

Super-Exchange Interaction Induced Overall Optimization in Ferromagnetic Perovskite Oxides Enables Ultrafast Water Oxidation.

Oxygen evolution reaction (OER) is crucial in many renewable electrochemical technologies including regenerative fuel cells, rechargeable metal-air batteries, and water splitting. It is found that abundant active sites with favorable electronic structure and high electrical conductivity play a dominant role in achieving high electrocatalytic efficiency of perovskites, thus efficient strategies need to be designed to generate multiple beneficial factors for OER. Here, highlighted is an unusual super-exchange effect in ferromagnetic perovskite oxide to optimize active sites and enhance electrical conductivity.

Improved catalytic combustion of methane using CuO nanobelts with predominantly (001) surfaces.

Through computational calculations, CuO(001) has been identified as an active surface for methane oxidation. Experimental validation with CuO nanobelts comprised of predominantly (001) surfaces has been performed and it is confirmed that the performance of such nanobelts is much higher than normal nanoparticles and nanowires. First principle calculations further clarified that two-coordinated oxygen plays a key role for methane adsorption and oxidation.