Determining the status of tertiary lymphoid structures in invasive pulmonary adenocarcinoma based on chest CT radiomic features.

Objectives: The aim of this study was to determine the status of tertiary lymphoid structures (TLSs) using radiomic features in patients with invasive pulmonary adenocarcinoma (IA).

Methods: In this retrospective study, patients with IA from November 2015 to March 2024 were recruited from two independent centers (center 1, training and internal test data set; center 2, external test data set). TLS was divided into two groups according to hematoxylin-eosin staining.

Identification of novel ferroptosis-related biomarkers associated with the oxidative stress pathways in ischemic cardiomyopathy.

Background: Ferroptosis is a cell death process that depends on iron and reactive oxygen species. It significantly contributes to cardiovascular diseases. However, its exact role in ischemic cardiomyopathy (ICM) is still unclear.

Correlation between the systemic immune-inflammation indicator (SII) and serum ferritin in US adults: a cross-sectional study based on NHANES 2015-2018.

Background & Objective: The systemic immune-inflammation indicator (SII) has been extensively employed in various diseases for course change, treatment efficacy, or prediction, whereas whether it applies to iron overload or iron deficiency remains unclear. This study aimed at investigating the correlation between SII and serum ferritin in people aged over 20 in the US.

Methods: The measurements of the systemic immune-inflammation indicator (SII = platelet count × neutrophil-to-lymphocyte ratio) and serum ferritin of 5491 participants in the NHANES database served as the independent and dependent variables for the present cross-sectional study, respectively.

Relationship between serum uric acid and estimated glomerular filtration rate in adolescents aged 12-19 years with different body mass indices: a cross-sectional study.

Background: Globally, chronic kidney disease (CKD) is a growing public health concern. Serum uric acid (SUA) is an easily detectable and readily available biochemical indicator that has long been recognized as an independent risk factor for CKD. In addition, studies have indicated a potential relationship between SUA and body mass index (BMI).

Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis.

Endoplasmic reticulum (ER) stress has been implicated in the mechanisms underlying the fibrotic process in dilated cardiomyopathy (DCM) and results in disease exacerbation; however, the molecular details of this mechanism remain unclear. Through microarray and bioinformatic analyses, we explored genetic alterations in myocardial fibrosis (MF) and identified potential biomarkers related to ER stress. We integrated two public microarray datasets, including 19 DCM and 16 control samples, and comprehensively analyzed differential expression, biological functions, molecular interactions, and immune infiltration levels.

Changes of nitrogen and phosphorus removal pattern caused by alternating aerobic/anoxia from the perspective of microbial characteristics.

The purpose of this study was to compare the impact of different numbers of alternating aerobic/anoxic (A/O) cycles on pollutant removal. Three sequential batch reactors (SBRs) with varying numbers of alternating A/O cycles were established. Under the tertiary anoxic operating conditions, the removal efficiencies of chemical oxygen demand (COD), ammonia nitrogen (NH-N), total nitrogen (TN), and total phosphorus (TP) were 88.

Prevalence and correlates of elder neglect in the community-dwelling Chinese population: New evidence from the CLHLS study.

Background: This study aimed to explore the prevalence of elder neglect (EN) and its associated factors among community-based Chinese older adults.

Methods: We used data from the 2018 phase of a nationwide cross-sectional study, the Chinese Longitudinal Healthy Longevity Survey (CLHLS), which recruited 15,854 older adults to complete the study interviews that incorporated six dimensions of EN, namely, life neglect, social isolation, medical neglect, poor living situation, family neglect, and social neglect. Multivariate logistic regression was used to explore factors associated with EN.

Calculation and evaluation of suitable ecological flows for eco-environmental recovery of cascade-developed rivers.

River cascade development affects the hydrological and habitat characteristics of the region and disrupts the dynamic balance of stable river ecosystems. The most profound impact of river cascade development is on the resident fish species. River ecosystem restoration for maximum river habitat improvement is generally based on water security and environment improvement and effectively embodies the nature-based solutions (NbS) concept of naturalized restoration.

[Value of serum procalcitonin and acute physiology and chronic health evaluation II score on predicting the prognosis of sepsis in elderly patients].

Objective: To explore the value of serum procalcitonin (PCT) and acute physiology and chronic health evaluation II (APACHE II) score on predicting prognosis of elderly patients with sepsis.

Methods: A retrospective cohort study, patients with sepsis who admitted to the department of emergency and the department of geriatric medicine of Peking University Third Hospital from March 2020 to June 2021 were enrolled. Patients' demographics, routine laboratory examinations, APACHE II score that within 24 hours of admission were obtained from their electronic medical records.

Relationship between bisphenol A and the cardiovascular disease metabolic risk factors in American adults: A population-based study.

Background: Bisphenol A (BPA) is widely used in personal care and consumer products. However, no study has reported a specific relationship between BPA concentrations and metabolic hazardous elements for cardiovascular diseases (CVDs). Consequently, in this study, we used six years of population-based NHANES data (2011-2016) to analyse the association between BPA concentrations and metabolic risk factors for CVDs.

Association of blood mercury levels with bone mineral density in adolescents aged 12-19.

Bone mass increases rapidly in adolescence, and achieving higher bone mineral density (BMD) during this period can help prevent osteoporosis. However, the effects of metallic mercury on bone health remain controversial. Previous studies have discussed perimenopausal women and older adults, while the association of blood mercury with BMD in adolescents is yet to be studied.

Interactive influences of ecosystem services and socioeconomic factors on watershed eco-compensation standard "popularization" based on natural based solutions.

Watershed eco-compensation is a policy tool to realize watershed environment improvement and regional economic development. It is important to eliminate the influence of economic differences between upstream & downstream regions and realize the fairness of regional social development based on Natural based Solutions (NbS). At present, lack of clarity in coupling and coordination analysis of ecosystem services & socioeconomic based on NbS could hamper watershed eco-compensation standards "popularization" and reduce the ability to successfully ecological governance.

Adsorption Characteristics of Phosphate Based on Al-Doped Waste Ceramsite: Batch and Column Experiments.

Phosphorus widely existing in rainfall and wastewater impacts the water environment. In this study, sludge, cement block, and coal fly ash were employed as ceramsite material to synthesize Al-doped waste ceramsite (Al-ceramsite) for removing phosphate (PO-P) from aqueous solutions. Batch static adsorption-desorption experiments were designed to investigate the effect of various parameters such as Al-ceramsite dosage, PO-P concentration, temperature, initial pH, coexisting ions, and desorbents on the removal of PO-P.

Derivation of new resistance principle on flow-induced morphological response of flexible vegetation.

Water flow under vegetated environments is a noteworthy research topic in environmental hydraulics and restoration ecology, and this research is particularly important for maintaining water transport and streambed stability in water ecosystems. The calculation of the resistance coefficient in vegetated water flow is the core of this research. But there are still problems such as complex expressions and low simulation accuracy in this research field.

Association of mutation with tumor mutation load and clinical outcomes in patients with gastric cancer.

Stomach adenocarcinoma (STAD) is one of the most frequently diagnosed cancers in the world with a poor prognosis due to genetic heterogeneity. The present study aimed to explore potential prognostic predictors and therapeutic targets that can be used for STAD treatment. We collected relevant data of STAD patients from the Cancer Genome Atlas (TCGA), including somatic mutation, transcriptome, and survival data.

Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory syndrome. The central pathogenesis is an explosive cytokine storm characterized by a significant increase in proinflammatory cytokines, including IL-1β, IL-6, IL-18, IFN-γ, and TNF-α. Meanwhile, negative regulatory factors, such as IL-10 and TGF-β, are also related to the production of HLH.

The Association Between Smoking and Renal Function in People Over 20 Years Old.

Background: Many conclusions have been reached in renal function studies in direct smokers.

Aim: This study aimed to determine the relationship between smoking and decreased renal function to ensure that reduced chronic kidney disease incidence can be achieved by limiting smoking, we assessed the relationship between cigarette smoking and renal function.

Methods: We recruited 10,267 people from the National Health and Nutrition Program Testing Survey (NHANES) aged over 20 years from 2013 to 2018 to assess smoking exposure by serum cotinine.

Association of Sex Hormones and Sex Hormone-Binding Globulin Levels With Bone Mineral Density in Adolescents Aged 12-19 Years.

Background: Sex hormones are recognized to play a significant role in increasing bone mineral density (BMD) and promoting bone maturation during adolescence. The purpose of our study was to use a database with large population data to evaluate the association of BMD with sex hormones (including testosterone and estradiol) and sex hormone-binding globulin (SHBG) in adolescent boys and girls aged 12-19 years.

Methods: The data for our study were taken from the National Health and Nutrition Examination Survey 2013-2016, and we used weighted multiple linear regression models to assess the relationship between testosterone, estradiol, and SHBG and total BMD.

Noninvasive evaluation of hypoxia in rabbit VX2 lung transplant tumors using spectral CT parameters and texture analysis.

Aim: Noninvasive evaluation of hypoxia in rabbit VX2 lung transplant tumors using spectral CT parameters and texture analysis.

Materials And Methods: Twenty-five VX2 lung transplant tumors of twenty-two rabbits were included in the study. Contrast-enhanced spectral CT scanning in the arterial phase (AP) and venous phase (VP) was performed.

[Spatial Differences in Water Quality and Spatial Autocorrelation Analysis of Eutrophication in Songhua Lake].

To identify the spatial differences in the water quality and eutrophication characteristics of Songhua Lake, the largest artificial lake in northeast China, analysis of variance (ANOVA) and factor analysis were used to analyze the water quality sampling and testing results in 2017 in three regions, namely the main reservoir area of the Fengman Reservoir (MRAFR), the experimental area of the Songhua River Three Lakes Protection Zone (EASRTLPZ), and the Jiaohe River backwater area (JRBA). The nutrient status of the lake was evaluated by the trophic state index method, and the spatial correlation and aggregation status of the eutrophication level in Songhua Lake were studied using spatial autocorrelation analysis. The main results were as follows: ① the ANOVA showed that, except for dissolved oxygen and chlorophyll-a (Chl-a), there were significant differences (<0.

Determining the invasiveness of ground-glass nodules using a 3D multi-task network.

Objectives: The aim of this study was to determine the invasiveness of ground-glass nodules (GGNs) using a 3D multi-task deep learning network.

Methods: We propose a novel architecture based on 3D multi-task learning to determine the invasiveness of GGNs. In total, 770 patients with 909 GGNs who underwent lung CT scans were enrolled.

Pollution characteristics and risk assessment of surface sediments in the urban lakes.

The objective of the manuscript was to evaluate the concentration and distribution of nutrients and heavy metals (HMs) in the sediments of urban lakes, as well as the potential ecological risk to the lake. This paper discusses the risk assessment and its management via potential nature-based solutions (NBS), which are lessons learnt from nature. The HM pollution and potential ecological risk were evaluated using conventional geo-accumulation index (GI) and geo-accumulation vector (GV) model.

Stochastic trophic level index model: A new method for evaluating eutrophication state.

The trophic state index (TSI) and trophic level index (TLI) are commonly used methods for evaluating the eutrophication state of lakes and reservoirs. However, they are unable to overcome uncertainties such as calculation errors and spatial heterogeneity of evaluation indicators. To comprehensively evaluate the eutrophication state of a region, we introduce a probability density function and propose the stochastic trophic level index model (STLI).