Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicing.

Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate cancer progression. Here, we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues, tumors, and cell lines to establish a comprehensive full-length gallbladder transcriptomic atlas. It is of note that receptor tyrosine kinases were one of the most dynamic components with highly variable transcript, with Erb-B2 receptor tyrosine kinase 2 (ERBB2) as a prime representative.

The relationships between short video addiction, subjective well-being, social support, personality, and core self-evaluation: a latent profile analysis.

Background: The proportion of short video addiction (SVA) is increasing among different populations, and its impact on the adolescent group has attracted research attention in recent years. To better explore the heterogeneity of individuals addicted to short videos and the antecedents of their addiction, the present study used quantitative research to conduct a latent profile analysis (LPA) of college students' SVA from the perspective of internal and external resources.

Methods: Referring to the Interaction of Person-Affect-Cognition-Execution (I-PACE) theory, this study explores the relationship between subgroups of SVA on the one hand and subjective well-being (SWB), social support (SS), core self-evaluation (CSE), and extraversion on the other using latent profile analysis.