Publications by authors named "Yichen Zhao"

Academic stress is associated with lower engagement in healthy behaviors, including physical exercise, among middle school students. Based on Self-Determination Theory, this study examines the association between academic stress and physical exercise behavior among middle school students, exploring the mechanisms through the chained mediation of motivation and intention. Scales used in this study include the Academic Stress Scale, Autonomous and Controlled Motivation Scales, and Physical Exercise Intention and Behavior Scales to measure relevant variables.

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Aneurysmal rupture is the main cause of subarachnoid hemorrhage (SAH), leading to neurological and cognitive deficits. The clinical significance of enlarged perivascular spaces (EPVS) on aSAH (aneurysm subarachnoid hemorrhage) outcomes was unclear. Our aim was to explore the association between EPVS and the clinical outcomes of aSAH.

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In situ high-pressure Raman spectroscopy and synchrotron angular dispersive x-ray diffraction techniques, combined with first-principles calculations, have been performed to investigate the 1-methylhydantoin (C4H6N2O2, 1-MH) molecular crystal. High-pressure experiments have shown that phase I (monoclinic system) begins to transform into phase II (orthorhombic system) at pressures above 4.0 GPa, and the transformation range is from 4.

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DNA-protein crosslinks (DPCs) are endogenous and chemotherapy-induced genotoxic DNA lesions and, if not repaired, lead to embryonic lethality, neurodegeneration, premature ageing, and cancer. DPCs are heavily polyubiquitinated, and the SPRTN protease and 26S proteasome emerged as two central enzymes for DPC proteolysis. The proteasome recognises its substrates by their ubiquitination status.

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  • There is a lack of agreement on how to treat patients with severe atrial functional mitral regurgitation and heart failure, particularly those with long-standing atrial fibrillation; this study compares two treatment options: mitral valve repair plus the maze procedure versus catheter ablation.
  • The study involved 302 patients, assessing outcomes like mortality, atrial fibrillation recurrence, and heart failure readmissions, finding that surgical patients had fewer instances of these issues compared to those who underwent catheter ablation.
  • Despite surgical patients showing lower recurrence rates for atrial fibrillation and heart failure readmissions, no significant differences in long-term outcomes such as death or AF recurrence emerged when comparing the two groups, suggesting both methods can effectively reduce mitral
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Tea plants (Camellia sinensis L.) are prone to spring frosts, leading to substantial economic damage. WRKY transcription factors are key in plant abiotic stress responses, yet the role of CsWRKY29 in freezing tolerance is unclear.

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  • This study examined the flavor changes in black tea during fermentation with the fungus Eurotium cristatum using techniques like GC-MS, GC-IMS, and sensory evaluation.
  • The fermentation process led to a significant reduction in the bitter and astringent flavors while increasing the mellow taste, with 152 and 129 volatile organic compounds (VOCs) detected by GC-MS and GC-IMS, respectively.
  • Key aroma-active compounds associated with floral, honey, and sweet scents were identified, notably with day 4 of fermentation marking a critical point for flavor and aroma development, resulting in a more enjoyable and rich flavor profile in the final black tea product.
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DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome stability, there is no evidence of its direct role in the repair of DNA lesions. We discovered that lysosomes process topoisomerase 1 cleavage complexes (TOP1cc) DNA lesions in vertebrates.

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Objectives: To investigate the effects of transpalatal (TPA) wire dimension and temporary skeletal anchorage device (TSAD) position on maxillary molar intrusion.

Materials And Methods: The maxillary molar intrusion measurement system included a maxillary acrylic model, TPA, TSADs, and a three-dimensional Force/Moment (F/M) sensor. The intrusion patterns were categorized into six groups: buccal-mesial, buccal-distal, buccal-mesiodistal, palatal-mesial, palatal-distal, and palatal-mesiodistal.

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Background: Left atrial appendages (LAAs) play an important role in regulating left atrial function, and much evidence supports the possibility that changes in left atrial structure may cause or worsen mitral regurgitation. This study intended to investigate the outcomes of patients with mitral regurgitation who underwent left atrial appendage closure (resection or endocardial closure) during isolated surgical ablations.

Methods: Patients with mild or moderate mitral regurgitation who received isolated surgical ablations for atrial fibrillation (AF) in our center from 2013 to 2022 were referred.

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Background: Mitral valve repair (MVr) is an effective treatment for degenerative mitral regurgitation (DMR).And the outcomes and repair rates for posterior leaflet prolapse (PLP), anterior leaflet prolapse (ALP), and bileaflet prolapse (BLP) vary. This study aimed to compare the outcomes of mitral valve repair for patients with PLP, ALP, and BLP.

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The study of the fluid inclusions of W-Mo deposits in the mineralization area of Ningshan-Zhen'an , Shaanxi Province, China shows that the gas-liquid two-phase inclusions are mainly present in W-Mo deposits, and the ore-forming fluid can be divided into four types: high-temperature type, middle-high-temperature type, middle-temperature type and low-temperature type. The formation depths of the W-Mo mineralization range from 4.2 to 8.

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Hypoxia exerts a profound influence on the tumor microenvironment and immune response, shaping treatment outcomes and prognosis. Utilizing consistency clustering, we discerned two hypoxia subtypes in OPSCC bulk sequencing data from GEO. Key modules within OPSCC were identified through weighted gene correlation network analysis (WGCNA).

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The loss of dopaminergic neurons in the substantia nigra is a hallmark of pathology in Parkinson's disease (PD). Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) is the critical enzyme responsible for the degradation of asymmetric dimethylarginine (ADMA) which inhibits nitric oxide (NO) synthase and has been implicated in neurodegeneration. Mitochondrial dysfunction, particularly in the mitochondria-associated endoplasmic reticulum membrane (MAM), plays a critical role in this process, although the specific molecular target has not yet been determined.

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  • - The study investigates how shading enhances the quality of green tea by increasing theanine content, as previous research indicated shading improves the biosynthesis of key compounds in tea plants through specific gene down-regulation.
  • - The researchers analyzed tea leaf area, free amino acid content, and photosynthetic parameters under varying light conditions to confirm that moderate shading positively influences tea quality, rather than reducing it.
  • - Key findings showed the differential expression of genes involved in chlorophyll metabolism under shading, suggesting that specific gene regulation can lead to higher chlorophyll content and improved tea quality, ultimately enhancing the production of high-quality matcha.
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  • The study investigates the use of cardiac magnetic resonance feature tracking (CMR-FT) to differentiate between constrictive pericarditis (CP) and restrictive cardiomyopathy (RCM) by analyzing left atrial (LA) strain in patients.
  • Researchers enrolled 120 patients, including those with CP, RCM, and a control group, and measured LV and biatrial strain over an 8-year period.
  • Results show that LA strain significantly differentiates CP from RCM, particularly in patients with reduced left ventricular ejection fraction (LVEF), with LA strain demonstrating a strong diagnostic capability indicated by high area under the curve (AUC) values in ROC analysis.
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Forsythia suspensa tea is a popular traditional Chinese medicine decoction for its healthy and therapeutic benefits. However, its effects in bone metabolism were not clear. In recent study, we uncovered anti-osteoclastogenesis property of Phillygenin (Phi), a compound abundant in Forsythia suspensa leaves, and aimed to investigate the effect and mechanism of Phi on bone metabolism in vivo and in vitro.

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Tetracyclines are a class of commonly used four-ringed antibiotics. A series of DNA aptamers were recently obtained using the capture-SELEX (systematic evolution of ligands by exponential enrichment) method to bind to oxytetracycline, and one of the aptamers can bind to a few other tetracycline antibiotics as well. Upon binding to the aptamers, the intrinsic fluorescence of tetracycline antibiotics can be enhanced.

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  • The study investigates the potential of alisol B 23-acetate (AB23A) as a treatment for obesity by promoting white adipose tissue (WAT) browning and improving metabolic health in mice on a high-fat diet.
  • Experiments showed that AB23A reduced body weight, adipose tissue mass, improved glucose and insulin metabolism, and promoted energy expenditure without affecting food intake or physical activity.
  • Findings suggest that AB23A might be a low-risk alternative for obesity management by targeting lipid distribution and metabolic profiles.
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  • There is currently no evidence supporting the use of topology-optimized splints in treating distal radius fractures, which prompted a study to evaluate their effectiveness compared to traditional casts.
  • A randomized clinical trial involving 110 participants aimed to compare the outcomes of topology-optimized splint immobilization and cast immobilization over a 12-week period, including a 6-week treatment phase.
  • Results showed that at 6 weeks, the splint group had a statistically significant better mean Gartland-Werley wrist score compared to the cast group, but by 12 weeks, no significant differences were noted between the two groups.
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Avian malaria is a vector-borne parasitic disease caused by Plasmodium infection transmitted to birds by mosquitoes. The aim of this systematic review was to analyze the global prevalence of malaria and risk factors associated with infection in wild birds. A systematic search of the databases CNKI, WanFang, VIP, PubMed, and ScienceDirect was performed from database inception to 24 February 2023.

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  • - The study evaluated long-term outcomes in 1,069 patients who underwent mitral valve repair due to degenerative disease at Beijing Anzhen Hospital from 2010 to 2019, with an average follow-up of 4.7 years.
  • - Key findings showed that long-term survival rate was 94%, but 10 patients died in the hospital and 33 during follow-up, with 113 experiencing recurrent mitral regurgitation (MR) and 14 needing re-operation.
  • - Risk factors for long-term all-cause death were age and low ejection fraction, while recurrent MR was linked to factors like age, female sex, and postoperative residual MR.
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In this study, metagenomic sequencing technology was employed to analyze the ITS1 region sequence of the ITS rDNA gene of endophytic fungi and 16S sequence of endophytic bacteria in tea leaves with varying degrees of infection by tea blister blight disease as well as healthy tea leaves. Subsequently, a comparative analysis was conducted on the endophytic microbial diversity and the community structure in tea leaves. The findings of this investigation reveal a shift in the dominant endophytic fungal genera from to as the disease progressed.

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The generation of adventitious roots (ARs) is the key to the success of cuttings. The appropriate environment for AR differentiation in tea plants is acidic. However, the mechanism is unclear.

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