Publications by authors named "Yibo Meng"
Background: USP54, a ubiquitin-specific protease in the deubiquitinase (DUB) family, facilitates the malignant progression of several types of cancer. However, the role of USP54 in prostate cancer (PCa), especially castration-resistant prostate cancer (CRPC), remains unknown.
Methods: We established the CRPC LNCaP-AI cell line from the hormone-sensitive prostate cancer (HSPC) LNCaP cell line.
ANP32B inhibition suppresses the growth of prostate cancer cells by regulating c-Myc signaling.
Biochem Biophys Res Commun
February 2024
ANP32B is a histone chaperone that interacts with various transcription factors that regulate cancer cell proliferation, immigration, and apoptosis. c-Myc, a well-known oncogenic protein, is a principal player in the initiation and progression of prostate cancer (PC). The means by which ANP32B and c-Myc act remain unknown.
View Article and Find Full Text PDFChronic psoriasis is a kind of immune-mediated skin illness and the underlying molecular mechanisms of pathogenesis remain incompletely understood. Here, we used small RNA microarray assays to scan the differential expressed RNAs in psoriasis patient samples. The downstream miRNAs and its targets were predicted using bioinformatics analysis from online bases and confirmed using fluorescence in situ hybridization and dual‑luciferase report gene assay.
View Article and Find Full Text PDFBackground: The anti-tumor activities of Natural compounds and their derivatives are of great interest to pharmaceutical industries. Fisetin is one of prospective natural compounds in this regard but unfortunately with poor hydrophilicity.
Methods: The effects of unmodified and modified fisetin in cultured ovarian cancer cells were compared by transmission electronmicroscopy to determine apoptotic bodies, MTT assay to quantitate cell numbers, and fluorescence activated cell sorting analyse of various markers to determine the apoptotic state.
Article Synopsis
- This study looked at 885 patients with vulvar diseases in southwest China from 2006 to 2016 to understand vulvar cancer better.
- Researchers found that factors like age, smoking, and HPV infection increase the risk of developing vulvar cancer.
- They discovered that vulvar cancer patients were usually older, had fewer sexual experiences earlier in life, and had more pregnancies than those without cancer.
[The Antitumor Effects of Fisetin on Ovarian Cancer and ].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2016
Objectives: We attempted to survey the inhibit effect of fisetin with human ovarian cancer cell line SKOV3 and the xenograft and the mechanism of the effect.
Methods: The ovarian cancer cell line SKOV3 treated by fisetin were observed directly under the transmission electronmicroscope (TEM);MTT assay was used to determine cell viability.Flow cytometry was used to analyze the apoptosis in ovarian cancer cell line SKOV3.