Publications by authors named "Yibing Bao"
In domestic animals, the mechanisms by which the luteinizing hormone (LH) surge induces oocyte meiosis resumption and maturation through follicular somatic cells remain unclear. Given the pivotal roles of histone deacetylases (HDACs) in regulating gametogenesis, this study investigated the roles of HDACs in follicular granulosa cells (GCs) in mediating LH action during oocyte maturation in pigs. The results showed that histone deacetylase 4 (HDAC4) levels in cultured GCs increased in a time-dependent manner with follicle-stimulating hormone (FSH) stimulation but significantly decreased with LH treatment.
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- Premature ovarian insufficiency (POI) causes infertility due to accelerated loss of ovarian function, often linked to defects in folliculogenesis and ovulation failure, but the exact mechanisms are not fully understood.
- Researchers utilized advanced techniques, including whole genome sequencing and mouse models, to investigate the role of the polycomb repressive complex 1 (PRC1) in POI and ovarian follicle development.
- A specific mutation in a PRC1 component was found in a patient, and further studies showed that simultaneous deletion of two PRC1 components hindered cell proliferation and disrupted communication necessary for fertility, indicating that PRC1 is critical in regulating gene activity and may inform future POI treatments.