Gut microbial metabolite butyrate improves anticancer therapy by regulating intracellular calcium homeostasis.

Background And Aims: Gut microbiota are recognized to be important for anticancer therapy, yet the underlying mechanism is not clear. Here, through the analysis of clinical samples, we identify the mechanism by which the gut microbial metabolite butyrate inhibits HCC and then explore new strategies for HCC treatment.

Approach And Results: In our study, we demonstrate that gut microbial metabolite butyrate improves anticancer therapy efficacy by regulating intracellular calcium homeostasis.

CDK2AP1 influences immune infiltrates and serves as a prognostic indicator for hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a tumor with high malignancy and poor 5-years survival rate. Excellent tumor markers are very important for early clinical diagnosis and prognosis evaluation. Previous studies have shown that (Cyclin-dependent kinase 2-associated protein 1) is involved in cell-cycle and epigenetic regulation.