CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin.

Background: CD44 is highly expressed in most cancer cells and its cross-linking pattern is closely related to tumor migration and invasion. However, the underlying molecular mechanism regarding CD44 cross-linking during cancer cell metastasis is poorly understood. Therefore, the purpose of this study was to explore whether disruption of CD44 cross-linking in breast cancer cells could prevent the cells migration and invasion and determine the effects of CD44 cross-linking on the malignancy of the cancer cells.

Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer.

A variety of pathogenic microorganisms can promote the occurrence and development of malignant tumors by colonizing in the body. It has been shown that Porphyromonas gingivalis (P. gingivalis) can be colonized for a long time in upper gastrointestinal tumors and is closely related to the occurrence and development of esophageal cancer in previous studies of our team.

Evaluation of a continuous flow microbial fuel cell for treating synthetic swine wastewater containing antibiotics.

Microbial fuel cell (MFC) systems are promising technologies for wastewater treatment and renewable energy generation simultaneously. Performance of a double-chamber microbial fuel cell (MFC) to treat synthetic swine wastewater containing sulfonamide antibiotics (SMs) was evaluated in this study. The MFC was operated in continuous modes at different conditions.

Mechanistic insights into the effect of poly ferric sulfate on anaerobic digestion of waste activated sludge.

Poly ferric sulfate (PFS), one of the typical inorganic flocculants widely used in wastewater management and waste activated sludge (WAS) dewatering, could be accumulated in WAS and inevitably entered in anaerobic digestion system at high levels. However, knowledge about its impact on methane production is virtually absent. This study therefore aims to fill this gap and provide insights into the mechanisms involved through both batch and long-term tests using either real WAS or synthetic wastewaters as the digestion substrates.

Ensemble dimensionality reduction and feature gene extraction for single-cell RNA-seq data.

Single-cell RNA sequencing (scRNA-seq) technologies allow researchers to uncover the biological states of a single cell at high resolution. For computational efficiency and easy visualization, dimensionality reduction is necessary to capture gene expression patterns in low-dimensional space. Here we propose an ensemble method for simultaneous dimensionality reduction and feature gene extraction (EDGE) of scRNA-seq data.

Understanding the fate and impact of capsaicin in anaerobic co-digestion of food waste and waste activated sludge.

Anaerobic co-digestion is an attractive option to treat food waste and waste activated sludge, which is increasingly applied in real-world situations. As an active component in Capsicum species being substantially present in food waste in many areas, capsaicin has been recently demonstrated to inhibit the anaerobic co-digestion. However, the interaction between capsaicin and anaerobic co-digestion are still poorly understood.

Validity of whole genomes sequencing results in neoplasms in precision medicine.

Objective: To compare the whole genomes sequencing (WGS) results in the 100K Genomes project with the results of routine molecular diagnostics in precision medicine.

Materials And Methods: We analysed 374 cancers including a high tumour mutational burden (TMB-high) subgroup, defined as >10 non-synonymous single nucleotide variations per megabase. Colon cancers were evaluated for microsatellite instability (MSI), mismatch repair (MMR) genes and NRAS, KRAS and BRAF mutations using routine molecular diagnostics.

Enhancement of short-chain fatty acids production from microalgae by potassium ferrate addition: Feasibility, mechanisms and implications.

Anaerobic fermentation of microalgae was always hindered by its rigid cell wall structure. This paper reports a novel technique, i.e.

Spectroscopic Evidence for a Spin- and Valley-Polarized Metallic State in a Nonmagic-Angle Twisted Bilayer Graphene.

In the magic-angle twisted bilayer graphene (MA-TBG), strong electron-electron (e-e) correlations caused by the band-flattening lead to many exotic quantum phases such as superconductivity, correlated insulator, ferromagnetism, and quantum anomalous Hall effects, when its low-energy van Hove singularities (VHSs) are partially filled. Here our high-resolution scanning tunneling microscope and spectroscopy measurements demonstrate that the e-e correlation in a nonmagic-angle TBG with a twist angle θ = 1.49° still plays an important role in determining its electronic properties.

Modeling of completely autotrophic nitrogen removal process with salt and glycine betaine addition.

The susceptibility of the completely autotrophic nitrogen removal over nitrite (CANON) process to high salinity limits its widespread application. The addition of glycine betaine (GB), a type of compatible solutes that could resist osmotic stress, could be an effective strategy to enhance the salt tolerance ability of aerobic and anaerobic ammonium oxidizing bacteria (AOB and anammox bacteria) involved in the CANON process. This study aims to make use of mathematical modeling to systematically investigate the effects of salt and GB addition on the activities of AOB and anammox bacteria and the treatment performance of the CANON process.

CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor.

Most luminal breast carcinomas (BrCas) bearing PIK3CA mutations initially respond to phosphoinositide-3-kinase (PI3K)-α inhibitors, but many eventually become resistant. The underlying mechanisms of this resistance remain obscure. In this work, we showed that a CD44 state due to aberrant isoform splicing was acquired from adaptive resistance to a PI3Kα inhibitor (BLY719) in luminal BrCas.

Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2'-Deoxyguanosine.

Alterations in mitochondrial DNA are potentially associated with oxidative stress and may be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the association between mitochondrial DNA copy number (mtDNAcn) and NAFLD was not consistent. In addition, the association between inflammation and NAFLD has not been established yet.

Negative association between antioxidant vitamin intake and non-alcoholic fatty liver disease in Chinese non-diabetic adults: mediation models involving superoxide dismutase.

We aimed to explore the association between antioxidant vitamin intake, oxidative stress related markers and non-alcoholic fatty liver disease (NAFLD) by a cross-sectional analysis. A total of 241 non-diabetic participants from a Chinese rural cohort were included. NAFLD was diagnosed by abdominal ultrasound (NAFLD,  = 71; Non-NAFLD,  = 171).

A novel method for accurate extraction of liver capsule and auxiliary diagnosis of liver cirrhosis based on high-frequency ultrasound images.

Liver cirrhosis is a common chronic progressive disease with a high mortality rate. The early diagnosis and treatment of liver cirrhosis is an important research subject in the medical field. In this paper, a novel method is proposed for the accurate extraction of the liver capsule and auxiliary diagnosis of cirrhosis based on high frequency ultrasound images.

The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer.

Trastuzumab is a humanized mAb used to treat HER2-overexpressing breast cancer; however its mechanisms remain to be fully elucidated. Previous studies suggest a role for immunity in mediating trastuzumab-specific antitumor effects. This study evaluated the role(s) of trastuzumab and other antibodies on macrophage activation and Ab-dependent cell-mediated phagocytosis (ADCP) of HER2 breast cancer cells in vitro and in vivo.

Electrostimulation enhanced ammonium removal during Fe(III) reduction coupled with anaerobic ammonium oxidation (Feammox) process.

Ammonium removal in wastewater treatment plants requires a large number of energy input, such as aeration and the addition of organics. Alternative, more economical technologies for nitrogen removal from wastewater are required. This study comprehensively investigated the feasible of microbial electricity coupled with Fe(III) reduction promoting the anaerobic ammonium removal.

Influences of Longitudinal Heterogeneity on Nitrous Oxide Production from Membrane-Aerated Biofilm Reactor: A Modeling Perspective.

As a promising technology for sustainable nitrogen removal from wastewater, the membrane-aerated biofilm reactors (MABRs) performing autotrophic deammonification are faced with the problem of unwanted production of nitrous oxide (NO, a potent greenhouse gas). As a common tool to study NO production from such an MABR, the traditional one-dimensional modeling approach fails to simulate the existence of longitudinal gradients in the reactor and therefore might render NO production significantly deviated from reality. To this end, this work aims to study the influences of key longitudinal gradients (i.

Calcium peroxide eliminates grease inhibition and promotes short-chain fatty acids production during anaerobic fermentation of food waste.

Deterioration of anaerobic fermentation can occur with the presence of grease in food waste, but little information on eliminating this deterioration is currently available. In this study, it was found that the presence of 10 g/L grease decreased SCFAs production from 16.97 to 13.

Corrigendum to "Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor ".

[This corrects the article DOI: 10.1155/2020/7610436.].

[The Monitoring and Application of Transcranial Doppler Ultrasound in Patients with Severe Neurovascular Diseases].

Objective: To investigate the monitoring effect and application of transcranial Doppler ultrasound (TCD) in patients with severe neurovascular cerebrovascular diseases.

Methods: From December 2016 to October 2018, 96 patients with cerebrovascular disease in Department of Neurology and ICU, West China Hospital, Sichuan University were monitored by bedside TCD, including the detection of bilateral middle cerebral arteries (MCAs) through temporal window, and the detection of the basilar artery (BA) through occipital window, characterized by the peak systolic blood flow velocity, peak diastolic blood flow velocity, average peak blood flow velocity, vascular pulsatility index, vascular pulsatility index, vascular resistance index and blood flow spectrum morphology in local hemodynamic changes. According to the monitoring results, it was divided into vasospasm group, increased blood flow group and insufficient blood supply group.

tRNA-Derived Fragments in Podocytes with Adriamycin-Induced Injury Reveal the Potential Mechanism of Idiopathic Nephrotic Syndrome.

Idiopathic nephrotic syndrome (INS) is a disease involving injury to podocytes in the glomerular filtration barrier, and its specific causes have not been elucidated. Transfer RNA-derived fragments (tRFs), products of precise tRNA cleavage, have been indicated to play critical roles in various diseases. Currently, there is no relevant research on the role of tRFs in INS.

A Critical Review on Nitrous Oxide Production by Ammonia-Oxidizing Archaea.

The continuous increase of nitrous oxide (NO) in the atmosphere has become a global concern because of its property as a potent greenhouse gas. Given the important role of ammonia-oxidizing archaea (AOA) in ammonia oxidation and their involvement in NO production, a clear understanding of the knowledge on archaeal NO production is necessary for global NO mitigation. Compared to bacterial NO production by ammonia-oxidizing bacteria (AOB), AOA-driven NO production pathways are less-well elucidated.

Micropollutants cometabolism of microalgae for wastewater remediation: Effect of carbon sources to cometabolism and degradation products.

This study investigated the impacts of selective sole carbon source-induced micropollutants (MPs) cometabolism of Chlorella sp. by: (i) extracellular polymeric substances (EPS), superoxide dismutase and peroxidase enzyme production; (ii) MPs removal efficiency and cometabolism rate; (iii) MPs' potential degradation products identification; and (iv) degradation pathways and validation using the Eawag database to differentiate the cometabolism of Chlorella sp. with other microbes.

Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and -Cell Dysfunction.

The interplays of cellular aging and oxidative stress (OS) markers form a complex network, which has been reported to be interrelated with numerous age-related and metabolic diseases, including metabolic syndrome (MS). However, given the multifactorial mechanisms of MS, several important confounders such as dietary factors and the reciprocal effect among these markers have not been considered and adjusted in previous investigations regarding the associations of cellular aging and OS markers with MS and its related metabolic abnormalities. To explicate this, we conducted a cross-sectional study among 533 Chinese adults.

Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor .

Objectives: In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL).

Designs: The current cross-sectional analysis was based on data collected within a type 2 diabetes project. .