Evaluating the Effect of Depression, Anxiety, and Post-Traumatic Stress Disorder on Anti-Müllerian Hormone Levels Among Women Firefighters.

To assess whether depression, anxiety, and post-traumatic stress disorder (PTSD) are associated with serum anti-Müllerian hormone (AMH) levels. We used data from a sample of women firefighters from the Fire Fighter Cancer Cohort Study. Participant demographics, reproductive history, and self-reported clinical diagnosis of anxiety, depression, and PTSD were collected with serum for AMH analysis at enrollment.

Flexural Behavior of Innovative Glass Fiber-Reinforced Composite Beams Reinforced with Gypsum-Based Composites.

Glass Fiber-Reinforced Composite (GFRP) has found widespread use in engineering structures due to its lightweight construction, high strength, and design flexibility. However, pure GFRP beams exhibit weaknesses in terms of stiffness, stability, and local compressive strength, which compromise their bending properties. In addressing these limitations, this study introduces innovative square GFRP beams infused with gypsum-based composites (GBIGCs).

Continuously tunable low-loss phase shifter using weak-dispersion spoof surface plasmon polaritons.

We propose a continuously tunable low-loss phase shifter based on weak-dispersion spoof surface plasmon polariton (SSPP) waveguide. Unlike traditional designs of SSPP devices that rely on the strong-dispersion property, we address the high insertion loss issue by leveraging the weak-dispersion region of SSPP. A detailed study reveals the relation between the waveguide length, phase shift, and insertion loss of SSPP.

Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-κB pathway.

Human leukocyte antigen DR alpha (HLA-DRA) is recognized for its inhibitory effect on the progression of clear cell renal cell carcinoma (ccRCC); high HLA-DRA expression levels are positively correlated with improved prognosis in patients with ccRCC. In this study, we evaluated HLA-DRA expression in ccRCCs, its effects on tumor-associated macrophage recruitment, and the influence of polarization. Clinical cohort analyses revealed that elevated HLA-DRA expression in ccRCC cells was correlated with enhanced tumor infiltration by M1-type macrophages.

NSUN2 Promotes Head and Neck Squamous Cell Carcinoma Progression by Targeting EMT-Related Gene LAMC2 in an mC-YBX1-Dependent Manner.

Background/objectives: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and aggressive cancer with high rates of metastasis and poor prognosis. Recent research highlights the role of 5-methylcytosine (mC) in cancer progression. NSUN2, an mC methyltransferase, has been implicated in various cancers, but its role in HNSCC remains elusive.

DES/O microemulsion for solubilizing and delivering curcumin via the nasal administration to treat acute asthma.

As a natural small molecule drug derived from turmeric, curcumin is known for its good biosafety and a range of beneficial effects, including anti-inflammatory, anti-spasmodic, antioxidant, antibacterial, anti-tumor, and neuroprotective effects. Even though, its insolubility in water and instability severely limit its bioavailability and clinical applications. The present study developed a deep eutectic solvent (DES) in oil microemulsion (DES/O-ME) system loaded with Cur for intranasal administration, aiming to enhance both the solubility and permeability of Cur to significantly increase its bioavailability.

Multi-omics Graph Knowledge Representation for Pneumonia Prognostic Prediction.

Early prognostic prediction is crucial for determining appropriate clinical interventions. Previous single-omics models had limitations, such as high contingency and overlooking complex physical conditions. In this paper, we introduced multi-omics graph knowledge representation to predict in-hospital outcomes for pneumonia patients.

Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease.

Disease-modifying therapies are standard of care (SOC) for sickle cell disease (SCD), but hematopoietic cell transplantation (HCT) has curative potential. We compared outcomes prospectively through 2-years after biologic assignment to a Donor or No Donor (SOC) Arm based on the availability of an HLA-matched sibling or unrelated donor (BMTCTN 1503; NCT02766465). A donor search was commenced after eligibility confirmation.

Elevated 1-Hour Post Load Glucose as a Predictor for Telomere Attrition: a study based on a Chinese Community population.

Context: 1-hour post-load glucose (1h-PG) detects dysglycemia-related disorders more effectively than traditional glycemic parameters. Hyperglycemia accelerates aging, whether 1h-PG outperforms in predicting aging remains unclear.

Objective: To Compare the effectiveness of 1h-PG with other glycemic parameters in identifying and predicting telomere attrition.

Effect, Fate and Remediation of Pharmaceuticals and Personal Care Products (PPCPs) during Anaerobic Sludge Treatment: A Review.

Biomass energy recovery from sewage sludge through anaerobic treatment is vital for environmental sustainability and a circular economy. However, large amounts of pharmaceutical and personal care products (PPCPs) remain in sludge, and their interactions with microbes and enzymes would affect resource recovery. This article reviews the effects and mechanisms of PPCPs on anaerobic sludge treatment.

Global burden of dementia in younger people: an analysis of data from the 2021 Global Burden of Disease Study.

Background: Dementia among younger people is rapidly emerging as a global health concern; however, comprehensive research on its shifting burden trends remains insufficient.

Methods: Data on the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) associated with dementia occurring in individuals <70 years were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Average annual percentage changes (AAPCs) were calculated to assess trends in age-specific rates (ASRs), including age-specific prevalence rates (ASPRs), age-specific incidence rates (ASIRs), age-specific mortality rates (ASMRs), and age-specific DALY rates (ASDRs) while young-onset dementia (YOD) burden trends were analyzed.

Xylem embolism induced by freeze-thaw and drought are influenced by different anatomical traits in subtropical montane evergreen angiosperm trees.

Subtropical evergreen broadleaved forests distributed in montane zones of southern China experience seasonal droughts and winter frost. Previously, studies have recognized that xylem anatomy is a determinant of its vulnerability to embolism caused by drought and freezing events. We hypothesized that there is a coordination of xylem resistance to freeze-thaw and drought-induced embolism for the subtropical montane evergreen broadleaved tree species because they are influenced by common xylem structural traits (e.

The negative association between sodium-driven nutrient pattern and telomere length: the chain mediating role of diastolic pressure and waist circumference.

Background: Numerous single nutrients have been suggested to be linked with leukocyte telomere length (LTL). However, data on nutrient patterns (NPs), particularly in Chinese population, are scarce. This study aimed to examine the relationship between nutrient-based dietary patterns and LTL, and the potential role of metabolic factors.

Alkali-Stable Metal-Organic Frameworks with Enhanced Electroconductivity for Black-Brown Electrochromic Energy Storage Smart Window.

Metal-organic frameworks (MOFs) deliver potential applications in electrochromism and energy storage. However, the poor intrinsic conductivity of MOFs in electrolytes seriously hampers the development of the above-mentioned electrochemical applications, especially in one MOF electrode. Herein, a new Ni-based MOF (denoted Ni-DPNDI) is proposed with enhanced conductivity by π-delocalized DPNDI connectors.

Impact of rosuvastatin on metabolic syndrome patients with moderate to severe metabolic associated fatty liver disease without overt diabetes: A randomized clinical trial.

Objective: This investigation aimed to evaluate the efficacy and safety of rosuvastatin in treating moderate to severe metabolic associated fatty liver disease (MAFLD).

Methods: This prospective, open-label, randomized study included non-diabetic participants with metabolic syndrome and intrahepatocellular lipid (IHCL) levels >10 %, as determined by proton magnetic resonance spectroscopy (H-MRS). The primary objective was the effect of a 52-week rosuvastatin treatment (10 mg/day) on IHCL content.

A novel strategy for spinal cord reconstruction via vascularized allogeneic spinal cord transplantation combine spinal cord fusion.

Aims: Spinal cord injuries (SCI) pose persistent challenges in clinical practice due to the secondary injury. Drawing from our experience in spinal cord fusion (SCF), we propose vascularized allogeneic spinal cord transplantation (vASCT) as a novel approach for SCI, much like organ transplantation has revolutionized organ failure treatment and vascularized composite-tissue allotransplantation has addressed limb defects.

Materials And Methods: In this study, 24 dogs were paired and underwent vASCT, with donor spinal cord grafts and polyethylene glycol (PEG) application for SCF.

Condensed tannin improves growth and alleviates intestinal inflammation of juvenile largemouth bass (Micropterus salmoides) fed with high cottonseed protein concentrate diet.

The objective of this study was to examine the potential of condensed tannin (CT) in mitigating the adverse effects on growth and intestinal health induced by high cottonseed concentrate protein (CPC) diets in juvenile largemouth bass (Micropterus salmoides). Largemouth bass were respectively fed with the basic diet, the high CPC diet, and the CPC + CT diet (incorporated 3.75 g/kg CT into the high CPC diet) for a duration of 8 weeks.

Electrochemical production of HO and O for sulfide removal from sewage.

In this study, a comparative analysis of two electrochemical methods for sulfide control in sewer networks was performed for the first time. In addition, the mechanism of sulfide control by HO was elucidated, and an analysis of the device operation and electrolyte selection was performed. The two-electron oxygen reduction reaction (2e-ORR) using untreated gas diffusion electrode (GDE) was superior to the hydrogen evolution reaction (HER) using stainless-steel mesh in terms of cell voltage, product formation, and sulfide suppression.

Selenium increases antimony uptake in As-hyperaccumulators Pteris vittata and Pteris cretica by promoting antimonate reduction: GSH-GSSG cycle and arsenate reductases HAC1/ACR2.

Selenium-enhanced arsenic uptake by As-hyperaccumulators Pteris vittata and Pteris cretica is known, but how it impacts antimony (Sb) uptake and associated mechanisms are unclear. Here, we investigated the effects of 2.5 μM selenate (Se) on Sb uptake by two plants after growing for 10 days under hydroponics containing 10 or 50 μM antimonate (SbV) (Sb or Sb).

A Novel Infection-Related Inflammatory Response-Related Genes Signature Predicts the Prognosis of Esophageal Squamous Cell Carcinoma.

Background: Our previous research showed that () infection can activate the inflammatory signaling pathway and promotes the malignancy development of esophageal squamous cell carcinoma (ESCC). However, the prognostic significance of inflammatory response-related genes (IRRGs) in -infected ESCC requires further elucidation. Hence, our study constructed a prognostic signature based on and IRRGs to forecast the survival of patients with ESCC, which may provide insight into new treatment options for ESCC patients.

Interaction of poly dimethyl diallyl ammonium chloride with sludge components: Anaerobic digestion performance and adaptive changes of anaerobic microbes.

The wide utilization of poly dimethyl diallyl ammonium chloride (polyDADMAC) in industrial conditions leads to its accumulation in waste activated sludge (WAS), thereby affecting subsequent WAS treatment processes. This work investigated the interaction between polyDADMAC and WAS components from the perspective of anaerobic digestion (AD) performance and anaerobes adaptability variation. The results showed that polyDADMAC decreased the content of biodegradable organic substrates (i.