Predicting Pancreatic Cancer in New-Onset Diabetes Cohort Using a Novel Model With Integrated Clinical and Genetic Indicators: A Large-Scale Prospective Cohort Study.

Introduction: Individuals who develop new-onset diabetes have been identified as a high-risk cohort for pancreatic cancer (PC), exhibiting an incidence rate nearly 8 times higher than the general population. Hence, the targeted screening of this specific cohort presents a promising opportunity for early pancreatic cancer detection. We aimed to develop and validate a novel model capable of identifying high-risk individuals among those with new-onset diabetes.

Bibliometric and Visual Analysis of Studies on Ceramic Membranes: A Review.

As a high-performance separation material, the ceramic membrane has played a crucial role in addressing resource, energy, and environmental challenges. Here, we carried out literature retrieval and collection for the research of ceramic membranes based on the Web of Science. The retrieval strategy was quantitatively evaluated from two dimensions: recall and precision.

Two-Dimensional MFI-Type Zeolite Flow Battery Membranes.

Vanadium flow battery (VFB) is one of the most reliable stationary electrochemical energy-storage technologies, and a membrane with high vanadium resistance and proton conductivity is essential for manufacturing high-performance VFBs. In this study, a two-dimensional (2D) MFI-type zeolite membrane was fabricated from zeolite nanosheet modules, which displayed excellent vanadium resistance (0.07 mmol L h ) and proton conductivity (0.

Parachute-like pull-through anastomosis for low rectal cancer: a new method for preservation of anal function.

Background: With recent improvements in surgical technique, oncological outcomes of low rectal cancer have improved over time. But the QoL impairment as a result of anal functional disorder cannot be ignored. And the incidence of anastomosis-related complications cannot be ignored.

Efficient Estimation of Permeate Flux of Asymmetric Ceramic Membranes for Vacuum Membrane Distillation.

Ceramic membranes have the advantages of high mechanical strength and thermal stability and are promising candidates for membrane distillation. Ceramic membranes are generally designed to have a multilayer structure with different pore sizes to create a high liquid entry pressure and obtain a high permeability. However, these structural characteristics pose significant difficulties in predicting permeate flux in a ceramic membrane contactor for vacuum membrane distillation (VMD).

Permeability and Stability of Hydrophobic Tubular Ceramic Membrane Contactor for CO Desorption from MEA Solution.

Ceramic membrane contactors hold great promise for CO desorption due to their high mass transfer area as well as the favorable characteristics of ceramic materials to resist harsh operating conditions. In this work, a hydrophobic tubular asymmetric alpha-alumina (α-AlO) membrane was prepared by grafting a hexadecyltrimethoxysilane ethanol solution. The hydrophobicity and permeability of the membrane were evaluated in terms of water contact angle and nitrogen (N) flux.

Preoperative recurrence prediction in pancreatic ductal adenocarcinoma after radical resection using radiomics of diagnostic computed tomography.

Background: The high recurrence rate after radical resection of pancreatic ductal adenocarcinoma (PDAC) leads to its poor prognosis. We aimed to develop a model to preoperatively predict the risk of recurrence based on computed tomography (CT) radiomics and multiple clinical parameters.

Methods: Datasets were retrospectively collected and analysed of 220 PDAC patients who underwent contrast-enhanced computed tomography (CE-CT) and received radical resection at 3 institutions in China between 2013 and 2017, with 153 from one institution as a training set, the remaining 67 as a validation set.

Enhanced Performance of Fly Ash-Based Supports for Low-Cost Ceramic Membranes with the Addition of Bauxite.

Support is a necessary foundation for ceramic membranes to achieve high performance. Finding the optimum balance between high performance and low cost is still a significant challenge in the fabrication of ceramic supports. In this study, low-cost fly ash-based ceramic supports with enhanced performance were prepared by the addition of bauxite.

Multi-institutional development and external validation of machine learning-based models to predict relapse risk of pancreatic ductal adenocarcinoma after radical resection.

Background: Surgical resection is the only potentially curative treatment for pancreatic ductal adenocarcinoma (PDAC) and the survival of patients after radical resection is closely related to relapse. We aimed to develop models to predict the risk of relapse using machine learning methods based on multiple clinical parameters.

Methods: Data were collected and analysed of 262 PDAC patients who underwent radical resection at 3 institutions between 2013 and 2017, with 183 from one institution as a training set, 79 from the other 2 institution as a validation set.

Exosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p/TNFRSF1B Pathway.

Background: Pancreatic cancer (PC) was regarded as the 4th principal cause of cancer-related fatalities in the United States and patients usually suffered from severe nutrition deficiency, muscle wasting, as well as bone loss. In our previous research, we have found that PC-derived exosomes potentially initiate insulin resistance in skeletal muscle cells. However, the role of exosomes in the PC-related bone loss remains unknown.

Perillaldehyde Ameliorates Aspergillus fumigatus Keratitis by Activating the Nrf2/HO-1 Signaling Pathway and Inhibiting Dectin-1-Mediated Inflammation.

Purpose: The purpose of this study was to investigate the therapeutic effect of perillaldehyde (PAE) on Aspergillus fumigatus (A. fumigatus) keratitis.

Methods: Human corneal epithelial cells (HCECs) were pretreated with PAE and stimulated with A.

Preparation of High Stability Pd/Ceramic/Ti-Al Alloy Composite Membranes by Electroless Plating.

High stability Pd/ceramic/Ti-Al alloy composite membranes were prepared by electroless plating. Ceramic membranes fabricated by an oxidation method were used as an inter-diffusion barrier between the Pd layer and the Ti-Al alloy support of the membranes to prevent intermetallic diffusion. The stabilities of the ceramic membranes at high temperatures in an H atmosphere were investigated.

Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway.

Dimethyl itaconate (DI) is a membrane-permeable itaconate derivative with anti-inflammatory functions. However, the anti-inflammatory effect of DI has never been studied in fungal keratitis. In this study, we tested the protective effect of DI against fungal keratitis and assessed the role of NF-E2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1) signaling in this process.

Molecular Bridges Stabilize Graphene Oxide Membranes in Water.

Recent innovations highlight the great potential of two-dimensional graphene oxide (GO) films in water-related applications. However, undesirable water-induced effects, such as the redispersion and peeling of stacked GO laminates, greatly limit their performance and impact their practical application. It remains a great challenge to stabilize GO membranes in water.

Dual-Subpopulation as reciprocal optional external archives for differential evolution.

Differential Evolution (DE) is powerful for global optimization problems. Among DE algorithms, JADE and its variants, whose mutation strategy is DE/current-to-pbest/1 with optional archive, have good performance. A significant feature of the above mutation strategy is that one individual for difference operation comes from the union of the optional external archive and the population.

Expression of GLS1 in intrahepatic cholangiocarcinoma and its clinical significance.

Kidney‑type glutaminase (GLS1) plays a significant role in tumor metabolism. Our recent studies demonstrated that GLS1 was aberrantly expressed in hepatocellular carcinoma (HCC) and facilitated tumor progression. However, the roles of GLS1 in intrahepatic cholangiocarcinoma (ICC) remain largely unknown.

Ultrasound Assisted Synthesis of Size-Controlled Aqueous Colloids for the Fabrication of Nanoporous Zirconia Membrane.

Permeation and separation efficiency of ceramic membranes are strongly dependent on their nanoporous structures, especially on the pore size. In this work, ultrasound is employed to form the size-controlled ZrO nanoparticles, and a ceramic membrane is prepared with tunable pore size. Under the ultrasound treatment, H from water plays a key role in the synthesis process.

Progress of immune checkpoint therapy in the clinic (Review).

Cancer cells can escape antitumor immune responses by exploiting inhibitory immune checkpoints. Immune checkpoint therapy, mainly including anti‑CTLA‑4 therapy and anti‑PD‑1/PD‑L1 therapy, can enhance antitumor immune responses by blocking the inhibitory signals of the immune system. This therapy has produced clinical advances in a fraction of patients.

Self-Cleaning Piezoelectric Membrane for Oil-in-Water Separation.

Ultrasound (US) treatment coupled with membrane filtration has been utilized for membrane fouling control in water treatment; however, large-scale implementation of ultrasonic cleaning equipment appeared to be cost-prohibitive. In this study, a porous lead zirconate titanate (PZT) membrane is presented that enables in situ ultrasound generation by the application of an alternating voltage (AV) to mitigate fouling during oil-in-water (O/W) emulsion separation. We expect that this method is much more cost-effective because it is more direct, avoiding buildup of fouling and the need to take the membrane offline.

Metabonomic potential plasma biomarkers in abnormal fast buoyancy ascent escape-induced decompression sickness model and the protective effects of pyrrolidine dithiocarbamic acid.

Background: Decompression sickness (DCS) induced by fast buoyancy ascent escape (FBAE) is a special DCS, characterized with cardiopulmonary injuries. Serum metabonomics of this type of DCS has not yet been studied. We proposed a metabonomics approach for assessing serum metabonomics changes and evaluating the preventive effect of pyrrolidine dithiocarbamic acid (PDTC) in FBAE-induced DCS rats.

Fabrication of mesoporous titania-zirconia composite membranes based on nanoparticles improved hydrosol.

A novel method for the fabrication of mesoporous titania-zirconia (TiO2ZrO2) composite membranes was successfully developed based on nanoparticles (NPs) improved hydrosol. ZrO2 hydrosols were synthesized through a straightforward sol-gel route using zirconium oxychloride. Compared to the polymeric sol route, this method was found to be more environmentally friendly because organic solvent was not required.

A reduced graphene oxide nanofiltration membrane intercalated by well-dispersed carbon nanotubes for drinking water purification.

In this study, we report a promising rGO-CNT hybrid nanofiltration (NF) membrane that was fabricated by loading reduced graphene oxide that was intercalated with carbon nanotubes (rGO-CNTs) onto an anodic aluminum oxide (AAO) microfiltration membrane via a facile vacuum-assisted filtration process. To create this NF membrane, the CNTs were first dispersed using block copolymers (BCPs); the effects of the types and contents of BCPs used on the dispersion of CNTs have been investigated. The as-prepared rGO-CNT hybrid NF membranes were then used for drinking water purification to retain the nanoparticles, dyes, proteins, organophosphates, sugars, and particularly humic acid.

Fabrication of mesoporous TiO2 membranes by a nanoparticle-modified polymeric sol process.

A straightforward synthesis of crack-free mesoporous titania membrane on a macroporous support without intermediate layers by a nanoparticle-modified polymeric sol-gel process is reported. TiO2 nanoparticle (Degussa P25) was dispersed into the prepared sol to toughen the formed gel. This helped to avoid the cracking of membrane during the drying and early stage of sintering, particularly when the sol-gel transformation occurred on a substrate with an uneven surface.

Fabrication of a visible-light response mesoporous TiO2 membrane with superior water permeability via a weak alkaline sol-gel process.

A visible-light response TiO(2) ultrafiltration membrane was fabricated via a weakly alkaline sol-gel method for the first time, and exhibited a cut-off molecular weight of 7500 Da and high pure water flux of 170 L m(-1) h(-1) bar(-1).