[Trade-off and Synergy of Ecosystem Services in the Yellow River Basin and Their Spatiotemporal Heterogeneity].

Exploring the trade-off and synergy between ecosystem services and their intrinsic impact mechanisms is crucial for improving the overall efficiency of ecosystems and ensuring the sustainable supply of ecosystem services. This study takes the 499 counties in the Yellow River Basin as the research object, uses the Pearson correlation coefficient method to measure the trade-off and synergy among counties, and constructs a geographically weighted logistic regression（GWLR） model to examine the spatiotemporal heterogeneity between balancing synergy and various influencing factors. The results showed that： ① From 2001 to 2021, the ecosystem service value of the Yellow River Basin first increased, then decreased, and finally increased, showing a spatial distribution pattern of "lower in the downstream, higher in the upper and middle reaches.

Periodic detection and disinfection maintenance of dental unit waterlines in dental simulation head model laboratories.

Dental simulation head model laboratories are crucial for clinical simulation training for stomatological students, yet the maintenance of their dental unit waterlines (DUWLs) has been overlooked. This study investigated water contamination in DUWLs within these laboratories and proposed solutions. Water samples were collected from 12 dental chairs in three laboratories at three time points: the beginning, middle, and end of the semester.

Acrylamide Induces Antiapoptotic Autophagy and Apoptosis by Activating PERK Pathway in SH-SY5Y Cells.

Acrylamide (ACR) is a commonly used organic compound that exhibits evident neurotoxicity in humans. Our previous studies showed that the mechanisms of ACR-caused neurotoxicity included apoptosis, PERK-mediated endoplasmic reticulum stress, and autophagy, but the relationships among them were still unclear. This paper investigated the relationships among apoptosis, autophagy, and the PERK pathway to demonstrate the mechanism of ACR neurotoxicity further.

Effect of early rehabilitation on hospital stay and postoperative complications in elderly hip fracture patients: a prospective cohort study.

Background: Hip fractures in the elderly are a major global public health concern, with incidence projected to rise as populations age. Rehabilitation is critical to recovery after hip fracture surgery, but the ideal timing for initiation remains uncertain. While early rehabilitation, within 48 h post-surgery, is associated with better outcomes, its specific impact on hospital stay duration and postoperative complications is not yet conclusively established.

Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.

Bisphenol F (BPF) has become a new risk factor for male semen quality, but its specific mechanism is still unclear. Therefore, this study explored the potential mechanism of BPF affecting male semen quality from the perspective of ferroptosis and m6A RNA methylation. In vivo experiments showed that BPF destroyed the structure of seminiferous tubules, reduced the layers of spermatogenic cells, and reduced semen quality in mice.

Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.

Hypoxia is a common feature of glioblastoma (GBM). Circular RNAs (circRNAs) are identified as regulators in cancers. However, the role of circRNAs in GBM remains elusive.

Research on Digital Terrain Construction Based on IMU and LiDAR Fusion Perception.

To address the shortcomings of light detection and ranging (LiDAR) sensors in extracting road surface elevation information in front of a vehicle, a scheme for digital terrain construction based on the fusion of an Inertial Measurement Unit (IMU) and LiDAR perception is proposed. First, two sets of sensor coordinate systems were configured, and the parameters of LiDAR and IMU were calibrated. Then, a terrain construction system based on the fusion perception of IMU and LiDAR was established, and improvements were made to the state estimation and mapping architecture.

Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time.

Ischemic stroke constitutes a multifaceted neurological affliction that spans various cellular types. Lack of dynamic chromatin accessibility data after stroke is one of the obstacles to understanding this process. To gain insights into the variations in transcriptional regulation among various cell types subsequent to a stroke, we employed single-nucleus ATAC-seq to curate a chromatin accessibility compendium from the cerebral cortex of mice subjected to middle cerebral artery occlusion/reperfusion (MCAO/R).

Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R.

Microcystin-LR (MC-LR), a prevalent cyanotoxin present in hazardous cyanobacterial blooms, is recognized as a neurotoxic environmental pollutant that induces brain damage and neurobehavioral deficits. However, the mechanisms underlying MC-LR-induced neurotoxicity remain unclear. This study aims to elucidate the role of mitophagy in MC-LR-induced neurotoxicity both in vitro and in vivo.

[Spatial Correlation Network and Influencing Factors of Carbon Emissions from Inter-provincial Tourism Transportation in China].

Clarifying the spatial correlation network structure from tourism transportation carbon emissions and its influencing factors is crucial for China's tourism and transportation industry to coordinate the planning of carbon reduction governance and realize the sustainable development of the tourism transportation industry. Based on inter-provincial panel data from 2001 to 2021, China's carbon emissions from tourism transportation were measured, and the modified spatial gravity model was used to construct characteristics of provincial spatial networks and their influencing factors, which were analyzed using the social network analysis method and the QAP model. The study showed that ① China's total carbon emissions from tourism and transportation have been growing slowly year by year, showing a distribution pattern of "high in the southeast and low in the northwest," with obvious differences between the eastern and western regions.

NEK2 promotes the progression of osteoarthritis by stabilizing ATF2 through phosphorylation at Ser-112 and inhibiting autophagy.

NEK2 (NIMA-related kinase 2) has recently gained attention for its potential role in osteoarthritis (OA) chondrocytes, however, its specific involvement remains unclear. This study aimed to investigate the role of NEK2 in OA progression and the underlying molecular mechanisms. Primary mouse knee chondrocytes were stimulated with IL-1β to establish an in vitro OA model, followed by the knockdown of NEK2 or ATF2.

Integrated Analysis of Gene Expression and Immune Cell Infiltration Reveals Dysregulated Genes and miRNAs in Acute Kidney Injury.

Acute Kidney Injury (AKI) is a multifaceted condition characterised by rapid deterioration of renal function, often precipitated by diverse etiologies. A comprehensive understanding of the molecular underpinnings of AKI is pivotal for identifying potential diagnostic markers and therapeutic targets. This study utilised bioinformatics to elucidate gene expression and immune infiltration in AKI.

Reproductive Toxicity and Multi/Transgenerational Effects of Emerging Pollutants on .

Emerging pollutants (EPs) are receiving increasing attention due to the threats they pose to the environment and human health. As EPs continue to emerge, risk assessment requires many model animals. () has been an outstanding toxicological model organism due to its growth and development characteristics.

Influencing mechanisms of renewable energy development on carbon emission intensity in China.

Faced with increasingly severe climate and energy crises, promoting renewable energy development has become an inevitable choice for realizing carbon reduction strategy and energy structure transformation. This paper selects the panel data of 30 provinces in China from 2001 to 2021 and constructs a dynamic spatial Durbin model to study the effect of renewable energy development on carbon emission intensity. The study shows a significant positive spatial correlation between renewable energy development and carbon emission intensity in Chinese provinces.

Integrated impacts of surrounding building density and gap permeability on pollutant dispersion in four-way street networks.

Gaps between buildings facing the streets can effectively accelerate the natural removal of pollutants in street canyons by enhancing ventilation and diffusion processes. This removal process is closely related to gap permeability (P, ratio of gap width to street length) and building density (λ) surrounding the streets. However, the integrated effects of these two parameters on pollutant dispersion remain unclear, because of the limited computational resources and the difficulty of traditional modeling methods to discrete the numerous buildings.

MRI findings of newly present benign focal hepatic observations following chemotherapy: distinct features in early- and late-term follow-up.

Objective: To evaluate gadoxetic acid-enhanced (Gd-EOB-DTPA) MRI features of newly detected benign focal hepatic observations after chemotherapy.

Methods: In this retrospective single-center case-control study, we enrolled a cohort of 43 cancer patients with 93 newly detected benign focal hepatic observations after chemotherapy between January 2010 and December 2020. We evaluated several parameters including the delay of occurrence after chemotherapy, imaging features, and imaging follow-up.

Macrophage accumulation in dorsal root ganglion is associated with neuropathic pain in experimental autoimmune neuritis.

Background: Neuropathic pain is a common symptom of Guillain-Barré syndrome (GBS). The infiltration of macrophages in the dorsal root ganglion (DRG) contributed to neuropathic pain in nerve injury. The underlying mechanisms of neuropathic pain in patients with GBS remain unknown.

Critical Role of S100A9 in Sepsis-associated Acute Kidney Injury: Mechanistic Insights through Pyroptosis Pathway Modulation.

This study investigates the role of S100A9 in sepsis-associated AKI (SA-AKI) through the lens of pyroptosis, a controlled form of cell death mediated by the gasdermin protein family. Using C57BL/6 mice and S100A9 knockout mice subjected to cecal ligation and puncture (CLP), RNA sequencing and bioinformatics analyses revealed differentially expressed genes (DEGs) related to inflammation and immune responses, with notable upregulation of S100A9. Functional enrichment analyses (GO and KEGG) indicated these DEGs are involved in interferon-beta response, immune processes, and cell adhesion.

Paeonol prevents sepsis-associated encephalopathy via regulating the HIF1A pathway in microglia.

Paeonol, a phenolic acid compound extracted from the Cortex Moutan, exhibits significant anti-inflammatory, antioxidant, and anti-apoptotic properties. This study aimed to investigate the effects of paeonol on neuroinflammation and depressive-like symptoms, and the underlying mechanisms in a mouse model of sepsis-associated encephalopathy (SAE) induced by lipopolysaccharide (LPS). To assess the therapeutic potential of paeonol in mice treated with LPS, behavioral assessments were conducted using the open-field test (OFT), tail suspension test (TST), and forced swimming test (FST), and quantitative PCR (qPCR), Western blot, and immunofluorescent staining were utilized to determine the expression levels of inflammatory molecules in the hippocampus in vivo and microglial cells in vitro.

[Spatiotemporal Differentiation of Carbon Budget and Carbon Compensation Zoning Based on the Plan for Major Function-oriented Zones：A Case Study of Counties in the Yellow River Basin].

Exploring the spatiotemporal differentiation of the carbon budget and clarifying the zoning of carbon compensation based on the perspective of the main function-oriented zones is of great significance for promoting regional low-carbon development and achieving the "dual carbon" goal. This study was conducted using 550 counties in the Yellow River Basin as the basic unit, and based on the concentration index to examine the spatial distribution characteristics of carbon emissions and carbon absorptions in the main function-oriented zones of the Yellow River Basin, a four-dimensional benchmark framework for carbon compensation zoning was constructed by total scale, economic contribution, ecological carrying capacity, and land development intensity. The SOM-K-means algorithm was used to establish a differentiated carbon compensation zoning scheme.

TIMM9 as a prognostic biomarker in multiple cancers and its associated biological processes.

TIMM9 has been identified as a mediator of essential functions in mitochondria, but its association with pan-cancer is poorly understood. We herein employed bioinformatics, computational chemistry techniques and experiments to investigate the role of TIMM9 in pan-cancer. Our analysis revealed that overexpression of TIMM9 was significantly associated with tumorigenesis, pathological stage progression, and metastasis.

Stanniocalcin-1 promotes temozolomide resistance of glioblastoma through regulation of MGMT.

Temozolomide (TMZ) resistance is a major challenge in the treatment of glioblastoma (GBM). Tumour reproductive cells (TRCs) have been implicated in the development of chemotherapy resistance. By culturing DBTRG cells in three-dimensional soft fibrin gels to enrich GBM TRCs and performing RNA-seq analysis, the expression of stanniocalcin-1 (STC), a gene encoding a secreted glycoprotein, was found to be upregulated in TRCs.

Long Non-Coding RNA : A Comprehensive Overview on Its Biological Functions and Clinical Significances in Human Cancers.

Long non-coding RNAs (lncRNAs) are well known for their oncogenic or anti-oncogenic roles in cancer development. , a new lncRNA, has been extensively demonstrated as an oncogenic lncRNA in various cancers. Abundant experimental results have proved the aberrantly high level of in a great number of malignancies, such as glioma, colorectal, lung, ovarian, prostate, breast, cholangiocarcinoma, bladder, colon and pancreatic cancers.

Multiparametric magnetic resonance imaging (MRI)-based radiomics model explained by the Shapley Additive exPlanations (SHAP) method for predicting complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicenter retrospective study.

Background: Predicting the response to neoadjuvant chemoradiotherapy (nCRT) before initiating treatment is essential for tailoring therapeutic strategies and monitoring prognosis in locally advanced rectal cancer (LARC). In this study, we aimed to develop and validate radiomic-based models to predict clinical and pathological complete responses (cCR and pCR, respectively) by incorporating the Shapley Additive exPlanations (SHAP) method for model interpretation.

Methods: A total of 285 patients with complete pretreatment clinical characteristics and T1-weighted (T1W) and T2-weighted (T2W) magnetic resonance imaging (MRI) at 3 centers were retrospectively recruited.

Hypoxia-responsive gene Promotes GBM Cell Proliferation and Migration through Activating NF-κB/p65 Signaling Pathway.

Glioblastoma multiforme (GBM) is the most common malignant form of glioma, but the molecular mechanisms underlying the progression of GBM in hypoxic microenvironment remain elusive. This study aims to explore the pathological functions of hypoxia-responsive genes on GBM progression and its downstream signaling pathways. RNA-seq was performed in normoxic and hypoxic U87 cells to identify the differentially expressed genes (DEGs) under hypoxia.