Greenness, Nighttime Light, and Couple Fecundability: A National Cohort Study Between 2014-2020.

Background: Reduced greenness and increased nighttime light (NTL) have been associated with adverse health outcomes; however, the impacts of greenness and NTL on human fecundability remain uncertain.

Methods: Data was collected from 14,239,365 couples across 31 provinces in China. Greenness exposure was estimated using the Normalized Difference Vegetation Index (NDVI) within 1000-meter buffer zones, while NTL data was derived from the Visible and Infrared Imaging Suite Day Night Band aboard satellites, both based on individual residential addresses.

SplitFusion enables ultrasensitive gene fusion detection and reveals fusion variant-associated tumor heterogeneity.

Gene fusions are common cancer drivers and therapeutic targets, but clinical-grade open-source bioinformatic tools are lacking. Here, we introduce a fusion detection method named SplitFusion, which is fast by leveraging Burrows-Wheeler Aligner-maximal exact match (BWA-MEM) split alignments, can detect cryptic splice-site fusions (e.g.

Depolymerization of oyster glycosaminoglycans for the enhancement of α-glucosidase inhibition and its application in hypoglycemic studies.

Glycosaminoglycans are a class of naturally occurring macromolecular heteropolysaccharides with α-glucosidase inhibitory effects, which play an essential role in regulating postprandial hyperglycemia. However, the significant molecular weight hinders their inhibitory activity. In this study, oyster glycosaminoglycans were used for purification and depolymerization studies to obtain oyster glycosaminoglycan oligosaccharides (OGAG-Oli) and to study their inhibitory activity against α-glucosidase in vitro and hypoglycemic effect on hyperglycemic zebrafish in vivo.

Leveraging diverse cell-death patterns in diagnosis of sepsis by integrating bioinformatics and machine learning.

Background: Sepsis is a life-threatening disease causing millions of deaths every year. It has been reported that programmed cell death (PCD) plays a critical role in the development and progression of sepsis, which has the potential to be a diagnosis and prognosis indicator for patient with sepsis.

Methods: Fourteen PCD patterns were analyzed for model construction.

Genome-wide identification of WOX family members in rose and functional analysis of RcWUS1 in embryogenic transformation.

WUSCHEL-related homeobox (WOX) is a class of plant-specific transcription factors and plays vital roles in plant development and evolution. Here, we analyzed WOX family genes of three Rosa species and explored their potential functions in Rosa. A total of 351 WOX genes were identified from Rosa chinensis 'Old Blush' (208), Rosa wichuraiana 'Basye's Thornless' (21) and Rosa rugosa (122).

HCN2 deficiency correlates with memory deficits and hyperexcitability of dCA1 pyramidal neurons in Alzheimer's disease.

Background: Abnormal excitability of hippocampal neurons may lead to dysfunction of neural circuits and then causes cognitive impairments in Alzheimer's disease (AD). However, the underlying mechanisms remain to be fully elucidated.

Methods: Electrophysiology was performed to examine the intrinsic excitability of CA1 neurons and the activity of the hyperpolarization-activated cyclic nucleotide-gated ion channels (HCNs) of CA1 neurons in wild type (WT) and hAPP-J20 mice.

Effects of pore water flow rate on microplastics transport in saturated porous media: Spatial distribution analysis.

Microplastics (MPs) pollution in subsurface environments poses significant ecological challenges, yet the understanding of their transport and retention behaviors remains limited. This study employs a two-dimensional porous media flow cell to investigate the migration and distribution of polystyrene MPs in saturated porous media under varying flow rates. We reveal that higher flow rates reduce overall retention but increase spatial autocorrelation in MP distribution, driven by particle accumulation in "transition pores" -pores that retain MPs occasionally.

Comprehensive analysis reveals the tumor suppressor role of macrophage signature gene FCER1G in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) progression is closely linked to the role of macrophages. This study utilized single-cell RNA sequencing and genomic analysis to explore the characteristic genes of macrophages in HCC and their impact on patient prognosis. We obtained single-cell se-quencing data from seven HCC samples in the GEO database.

Dynamical characteristics of tightly focused circularly polarized modulated autofocusing vortex beams and their optimized trapping performance for chiral nanoparticles.

By combining the improved properties of the Bessel modulated autofocusing beam [Phys. Rev. A104, 043524 (2021)PLRAAN1050-294710.

Cobalt-Zinc carbonaceous yolk-shell reactor enhances electron transfer in non-radical pathways: Electric potential concentration effect via bimetallic synergy.

Bimetallic catalysts have notable advantages in the field of persulfate activation owing to their intermetallic synergy. However, studies on stimulating the potential concentration effect through intermetallic coordination to enhance the electron transfer efficiency are limited. In this study, a cobalt (Co) and zinc (Zn) bimetallic yolk-shell structured high-efficiency peroxymonosulfate (PMS) catalyst (Z67@8-HCNF) was prepared by the derivatization of metal-organic backbone materials and was found to produce significant synergistic interactions between Co and Zn metals, which could be utilized to trigger the potential concentration effect to enhance the intermolecular electron transfer efficiency and achieve efficient PMS activation.

Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1.

Sterols target sterol-sensing domain (SSD) proteins to lower cholesterol and circulating and hepatic triglyceride levels, but the mechanism remains unclear. In this study, we identify acyl-coenzyme A (CoA) synthetase long-chain family member 1 (ACSL1) as a direct target of ergosterol (ES). The C-terminal domain of ACSL1 undergoes conformational changes from closed to open, and ES may target the drug-binding pocket in the acetyl-CoA synthetase-like domain 1 (ASLD1) of ACSL1 to stabilize the closed conformation and maintain its activity.

Trends in osteoporosis assessment, diagnosis after fragility fractures, and treatment for hospitalized patients with osteoporosis or fragility fractures between 2012 and 2021.

Unlabelled: Our study investigated trends in osteoporosis management in Xiamen from 2012 to 2021, revealing improvements in screening and treatment, although medication use remained low. Additionally, we identified factors that may influence medication use and emphasized the importance of effective osteoporosis management strategies.

Purpose: The goal of the current study is to explore trends in assessment, diagnosis after fragility fractures, and osteoporosis treatment among hospitalized patients in Xiamen, China, between 2012 and 2021.

Effectiveness of Virtual Reality Training in Improving Outcomes for Dialysis Patients: Systematic Review and Meta-Analysis.

Background: Virtual reality (VR) training uses computer-generated simulations that enable users to engage with immersive virtual environments, simulating real-world activities or therapeutic exercises. This technology is increasingly recognized as a promising intervention to address the physical and psychological challenges faced by dialysis patients, who frequently experience diminished physical function, social isolation, and emotional distress associated with prolonged treatment regimens. Given the increasing prevalence of dialysis patients and the limitations of conventional rehabilitation approaches, VR presents a novel, interactive method that has the potential to enhance patient well-being and improve quality of life.

Amivantamab Plus Lazertinib in Patients With EGFR-Mutant NSCLC After Progression on Osimertinib and Platinum-Based Chemotherapy: Results From CHRYSALIS-2 Cohort A.

Introduction: Treatment options for patients with EGFR-mutated NSCLC with disease progression on or after osimertinib and platinum-based chemotherapy are limited.

Methods: CHRYSALIS-2 cohort A evaluated amivantamab plus lazertinib in patients with EGFR exon 19 deletion- or L858R-mutated NSCLC with disease progression on or after osimertinib and platinum-based chemotherapy. Primary end point was investigator-assessed objective response rate (ORR).

A novel approach: enhancing marigold ( L.) genetic transformation through seed priming technology.

This research presents an innovative genetic transformation protocol for marigolds ( L.), a species of great significance in floriculture, impacting both yield and quality. The study introduces seed priming technology as a novel approach and evaluates its effect on the germination rate.

Comprehensive Analysis of Bulk RNA-Seq and Single-Cell RNA-Seq Data Unveils Sevoflurane-Induced Neurotoxicity Through SLC7A11-Associated Ferroptosis.

Sevoflurane's potential impact on cognitive function and neurodevelopment, especially in susceptible populations such as infants and the elderly, has raised widespread concern. This study focuses on how sevoflurane induces ferroptosis in astrocytes and identifies solute carrier family 7 member 11 (SLC7A11) as a mediator of ferroptosis, providing new insights into sevoflurane-related neurotoxic pathways. We analysed single-cell sequencing (scRNA-seq) data from sevoflurane-exposed mice and control mice, supplemented with bulk RNA-seq data, to assess gene expression alterations.

Study on the mechanical behavior and rupture characteristics of coal after thermal damage.

High temperature is a critical safety concern that poses challenges to the safe and efficient operation of coal mines. To explore the mechanical behavior and fracture mechanisms of coal exposed to high temperatures, coal samples were subjected to various thermal treatments. After cooling, uniaxial compression tests were performed using an electronic universal testing machine to assess their macroscopic properties.

Prognostic value of ubiquitination-related differentially expressed genes in esophageal squamous cell carcinoma: a comprehensive analysis and future directions.

Background: Esophageal squamous cell carcinoma (ESCC) represents a considerable health challenge, primarily due to its poor prognosis and the limited availability of effective therapeutic interventions. Ubiquitination, a vital post-translational modification, is integral to cellular regulation; nonetheless, its role in ESCC has not been thoroughly explored. This study aims to identify ubiquitination-related differentially expressed genes (URDEGs) that possess prognostic significance in the context of ESCC.

A novel framework for optimization and evaluation of sensors network in urban drainage system.

Efficient management of urban drainage system (UDS) is crucial for understanding the operating status of UDS and facilitating urban flood early warning. Establishing an appropriate sensor network is fundamental to achieving cost-effective and sustainable management of UDS. Previous researches have predominantly focused on optimizing sensor placement but have often overlooked the evaluation of sensor network performance.

The efficacy of neuroendoscopic surgery treating patients with thalamic hemorrhage accompanied by intraventricular hematoma.

Objective: Neuroendoscopic surgery (NES) has been proven to be safe and effective in hematoma evacuation for cerebral hemorrhage. However, its efficacy for thalamic hemorrhage accompanied by intraventricular hematoma (THAVH) remains unclear. The aim of this study is to determine the efficacy of NES in treating THAVH.