Trial sequential analysis involving same-year studies requires careful temporal ordering.

Trial sequential analysis (TSA) is an increasingly used tool in systematic reviews to monitor synthesized evidence. However, the current practice of TSAs often overlooks the order of same-year studies, which are typically ordered alphabetically based on the last names of the studies' authors by default in the widely used TSA software application. This practice is inappropriate and contrary to the TSA's definition.

Improving the Stability and Anti-Infective Activity of Sea Turtle AMPs Using Multiple Structural Modification Strategies.

Antimicrobial peptides (AMPs) are regarded as promising candidates for combating antimicrobial resistance. Previously we identified an AMP named -CATH2 from the green sea turtle, which exhibited potent antibacterial activity and attractive potential in application. However, natural AMPs including -CATH2 frequently suffer from structural instability and sensitivity to physiological conditions, limiting their effectiveness.

Does relative bracket base area affect the accuracy of reconstructed buccal surface in the virtual bracket removal technique?

Background: Virtual bracket removal (VBR) facilitates efficient retainer fabrication for fixed orthodontics in a digital workflow. This study is aimed at assessing the influence of the relative bracket base area (RBA), representing the proportion of the labial/buccal surface area intended for removal, on the surface reconstruction accuracy in the VBR technique.

Methods: 196 teeth from seven resin dental models were included.

Trace elements exposure affects the outcomes of in vitro fertilization embryo transfer, a cohort study in Northern China.

Purpose: With urbanization and industrialization process accelerated, humans are exposed more and more trace elements. This study aimed to explore the potential associations of trace elements with the outcomes of in vitro fertilization embryo transfer (IVF-ET).

Methods: Total 181 women who underwent IVF-ET were enrolled, among which 89 women underwent fresh ET after IVF.

AVATAR 2.0: next level communication systems for radiotherapy through face-to-face video, biofeedback, translation, and audiovisual immersion.

Purpose: This paper discusses an advanced version of our audiovisual-assisted therapeutic ambience in radiotherapy (AVATAR) radiolucent display systems designed for pediatric radiotherapy, enabling anesthesia-free treatments, video communication, and biofeedback. The scope of the AVATAR system is expanded here in two major ways: (i) through alternative mounting systems to accommodate a broader range of radiotherapy machines (specifically to fit robotic-arm and toroidal geometry photon radiotherapy and proton radiotherapy systems) and (ii) through additional hardware to provide video-calling, optimized audio for clear communication, and combined video inputs for biofeedback, translation, and other advanced functionalities.

Methods And Materials: Because robustness requires strong parts and radio-transparency requires thin, light parts, three-dimensional printing was used to rapidly prototype hollow structures and to iteratively improve robustness.

Method for remaining useful life prediction of rolling bearings based on deep reinforcement learning.

In contemporary industrial systems, the prediction of remaining useful life (RUL) is recognized as a valuable maintenance strategy for health management due to its ability to monitor equipment operational status in real time and ensure the safety of industrial production. Current studies have largely concentrated on deep learning (DL) techniques, leading to a shortage of RUL prediction methods that utilize deep reinforcement learning (DRL). To further enhance application and research, this paper introduces a novel approach to RUL prediction based on DRL, specifically using a combination of Convolutional Neural Network-Bidirectional Long Short-Term Memory Network (CNN-BiLSTM) and the Deep Deterministic Policy Gradient (DDPG) algorithm.

Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides.

Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate immune system. But their functions and association with antimicrobial peptides (AMPs) are incompletely understood. Here, we reveal a synergistic interaction between the AMP AW1 and the NDACP AW2, which are co-expressed in the frog Amolops wuyiensis.

Comparison of two popular transducers to measure sit-to-stand power in older adults.

The Tendo Unit (TU) and GymAware (GA) are the two most frequently used linear transducers for assessing muscle power in older adults via the sit-to-stand (STS) test. Unlike TU, GA incorporates a sensor mechanism to correct for non-vertical movements, which may lead to systematic differences between devices. The aim of this study therefore was to compare GA to TU for measuring STS power in community-dwelling older adults.

Neoadjuvant inetetamab and pertuzumab with taxanes and carboplatin (TCbIP) In locally advanced HER2-positive breast cancer: a prospective cohort study with propensity-matched analysis.

Background: Inetetamab is the first domestically developed innovative anti-HER2 monoclonal antibody in China, proven effective and safe in HER2-positive advanced breast cancer. However, its efficacy and safety in neoadjuvant treatment of HER2-positive locally advanced breast cancer (LABC) remain to be validated.

Methods: This prospective cohort study aimed to evaluate the efficacy and safety of inetetamab combined with pertuzumab, taxanes, and carboplatin (TCbIP) in neoadjuvant therapy for HER2-positive LABC, comparing it to data from patients treated with the TCbHP regimen (trastuzumab combined with pertuzumab, taxanes, and carboplatin) using propensity score matching (PSM).

Panthenol Additives with Multiple Coordination Sites Induce Uniform Zinc Deposition and Inhibited Side Reactions for High Performance Aqueous Zinc Metal Battery.

Application of aqueous zinc metal batteries (AZMBs) in large-scale new energy systems (NESs) is challenging owing to the growth of dendrites and frequent side reactions. Here, this study proposes the use of Panthenol (PB) as an electrolyte additive in AZMBs to achieve highly reversible zinc plating/stripping processes and suppressed side reactions. The PB structure is rich in polar groups, which led to the formation of a strong hydrogen bonding network of PB-HO, while the PB molecule also builds a multi-coordination solvated structure, which inhibits water activity and reduces side reactions.

Photocatalytic Multisite Functionalization of Unactivated Terminal Alkenes by Merging Polar Cycloaddition and Radical Ring-Opening Process.

Although highly appealing for rapid access of molecular complexity, multi-functionalization of alkenes that allows incorporation of more than two functional groups remains a prominent challenge. Herein, we report a novel strategy that merges dipolar cycloaddition with photoredox promoted radical ring-opening remote C(sp)-H functionalization, thus enabling a smooth 1,2,5-trifunctionalization of unactivated alkenes. A highly regioselective [3+2] cycloaddition anchors a reaction trigger onto alkene substrates.

Automated Design of Collaboration-Based Hybrid Metaheuristics.

Hybridization plays a prominent role in bolstering the performance of optimization algorithms (OAs), yet designing efficient hybrid OAs tailored to intricate optimization problems persists as a formidable task. This article introduces a novel top-down methodology for the automated design of hybrid OAs, treating algorithm design as a meta-optimization problem. A general design template for collaboration-based hybrid OAs is developed, integrating a multitude of hybridization strategies for the first time.

The adaptive mechanisms of the marine diatom Thalassiosira weissflogii to long-term high CO and warming.

While it is known that increased dissolved CO concentrations and rising sea surface temperature (ocean warming) can act interactively on marine phytoplankton, the ultimate molecular mechanisms underlying this interaction on a long-term evolutionary scale are relatively unexplored. Here, we performed transcriptomics and quantitative metabolomics analyses, along with a physiological trait analysis, on the marine diatom Thalassiosira weissflogii adapted for approximately 3.5 years to warming and/or high CO conditions.

Mechanical, Thermal Properties, and Extreme Phase Stability of High-Entropy Diborides (VNbTaCrW)B.

High-entropy diborides (HEDBs) have gained significant attention in industrial applications due to their vast composition space and tunable properties. We propose a solid solution reaction at high temperatures and pressures that successfully synthesized and sintered a novel, dense, and phase-pure HEDB (VNbTaCrW)B. A high asymptotic Vickers hardness of 26.

Durability and Mechanical Properties of Nano-SiO and Polyvinyl Alcohol Fiber-Reinforced Cementitious Composites Subjected to Saline Freeze-Thaw Cycles.

To investigate the effects of nano-SiO (NS) and polyvinyl alcohol (PVA) fibers on the durability and mechanical properties of cementitious composites subjected to saline freeze-thaw cycling, a series of PVA fiber-reinforced cementitious composite (PFRCC) specimens were prepared using various fiber contents, and a series of NS and PVA fiber-reinforced cementitious composite (NPFRCC) specimens were prepared using various combinations of NS and fiber contents. Durability and fracture toughness tests were subsequently conducted on the specimens after different numbers of saline freeze-thaw cycles. The results indicate that the degradation of material properties can be divided into slow and accelerated damage stages before/after 50 freeze-thaw cycles.

The Impact of Neoadjuvant Chemotherapy on Patients With T1N0M0 Triple-Negative and HER-2 Positive Breast Cancer: A Retrospective Analysis Based on the SEER Database.

Background: The utilization of neoadjuvant chemotherapy (NAC) originated in the treatment of locally advanced breast cancer (BC). Our study is designed to elucidate the effects of NAC on patients with T1N0M0 triple-negative and HER-2 positive BC.

Methods: This study involved the selection of 10,614 patients diagnosed with T1N0M0 triple-negative and HER-2 positive breast cancer (BC) from the surveillance, epidemiology, and end results (SEER) database.

Research on rolling bearing fault diagnosis method based on simulation and experiment fusion drive.

Aiming at the problem that the rolling bearing fault data are difficult to obtain and that the traditional fault diagnosis method does not consider the signal uncertainty characteristics and the low accuracy of models in the process of rolling bearing fault, a fault diagnosis method based on simulation and experiment fusion drive is proposed. First, the dynamics simulation model of rolling bearings under different fault conditions is established to obtain the bearing fault simulation signals. Second, a sequence generative adversarial network is used to fuse the simulation and experimental data.