Current trends and hotspots of etiology of auditory neuropathy in the past 30 years: A bibliometric analysis.

Objective: To make an overview of global research trends in the etiology of auditory neuropathy (AN) over the past 30 years using a bibliometric approach.

Methods: Bibliometric analyses were conducted by GraphPad Prism 9.0, Citespace 6.

Microbe-derived Bisindole Alkaloids with Anticancer Potential and Their Mechanisms: A Comprehensive Review.

Bisindole alkaloids constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the past six decades, researchers have isolated 425 microorganism-derived bisindole alkaloids (MDBAs). Among them, 187 MDBAs have demonstrated anticancer properties against various in vitro cancer cell lines, primarily by impeding the cell cycle, restraining cell proliferation, and inducing apoptosis and autophagy.

Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.

Aims/introduction: Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound-healing processes. Interleukin-37 (IL-37) is a natural suppressor of innate inflammation. Here, we aim to investigate the potential of IL-37 in enhancing the healing process of diabetic wounds.

Non-noble Metal Single-Molecule Photocatalysts for the Overall Photosynthesis of Hydrogen Peroxide.

Despite the great progress in molecule photocatalytic solar energy conversion, it is particularly challenging to realize a photocatalytic overall reaction in a non-noble metal complex, which represents a new paradigm for photosynthesis. In this study, a class of novel non-noble metal complexes with head-to-tail geometry were designed and readily synthesized via the coordination of triphenylamine-modified 2,2': 6',2″-terpyridine ligands with Zn. As expected, these complexes exhibited the desired through-space charge-transfer transition, generating both long-lived excited states (on the order of microseconds) and separate redox centers under visible-light irradiation.

Association between calculated remnant cholesterol levels and incident risks of Alzheimer's disease among elderly patients with type 2 diabetes: a real-world study.

Objective: Alzheimer's disease (AD) is a leading cause of dementia, with a rising global burden. Remnant cholesterol (RC), a component of triglyceride-rich lipoproteins, has been implicated in cardiovascular diseases and metabolic disorders, but its role in AD remains unclear. This study investigated the association between RC levels and the risk of AD among elderly patients with type 2 diabetes (T2D) in a real-world clinical setting.

Standardizing plaque impact on overall coronary hemodynamics using a binomial equation based on the equivalent energy loss.

This study proposes a novel method for evaluating the risk of adverse events (AE) in patients with coronary stenosis based on the morphology and hemodynamics along a whole coronary artery. Twenty-eight specific coronary artery tree models with different stenotic degrees are established from the CCTA images and divided into AE group and Non-AE group. Pressures are obtained by computational fluid dynamics method.

Curcumaones A-N, sesquiterpenes from the secondary rhizomes of Curcuma wenyujin.

Fourteen undescribed sesquiterpenes, named curcumaones A-N (1-14), as well as forty-four (15-58) known ones, were isolated from the secondary rhizomes of Curcuma wenyujin. The structures and absolute configurations of 1-14 were elucidated based on NMR spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data and electronic circular dichroism (ECD) spectral analysis. Among these, five sesquiterpenes with the peroxide linkage (1-5) were obtained and the change of chemical shift between the α-C connecting the peroxide linkage and the oxygen atom has been discussed.

A predictive model for cerebellar mutism syndrome based on lesion map in children with medulloblastoma.

Background: This study aimed to establish a voxel-based map to predict the occurrence of cerebellar mutism syndrome (CMS) and investigate the relationship between CMS and motor dysfunction.

Method: This multicenter study cohort included 224 patients diagnosed with medulloblastoma at Beijing Children's Hospital (n = 88) and Beijing Tiantan Hospital (n = 136). The dataset was randomly divided into training (n = 95), test (n = 41), and validation (n = 88) datasets.

Dependence of acoustophoretic aggregation on the impedance of microchannel's walls.

Background And Objectives: Acoustofluidic manipulation of particles and biological cells has been widely applied in various biomedical and engineering applications, including effective separation of cancer cell, point-of-care diagnosis, and cell patterning for tissue engineering. It is often implemented within a polydimethylsiloxane (PDMS) microchannel, where standing surface acoustic waves (SSAW) are generated by sending two counter-propagating ultrasonic waves on a piezoelectric substrate.

Methods: In this paper, we develop a full cross-sectional model of the acoustofluidic device using finite element method, simulating the wave excitation on the substrate and wave propagation in both the fluid and the microchannel wall.

Full conversion of lignocellulose using polyoxometalate catalysts with redox sites and antagonistic acidity/basicity.

The full utilization of lignocellulose involves two distinct catalytic routes: i) oxidative depolymerization of lignin and ii) acid/alkaline hydrolysis of hemicellulose and cellulose. To improve efficiency and reduce costs, constructing a single-cluster catalyst represents a desirable yet challenging strategy. Herein, triple-functional molecular polyoxometalates (POMs), NLLHVMoO (n = 1-6) were fabricated using N-lauroyl-l-lysine (NLL) and HVMoO as precursors.

Isoalcanivorax beigongshangi sp. nov., isolated from the fermented grains of Chinese baijiu.

A bacterial strain, REN37, was isolated from fermented grains of Baijiu samples collected from Sichuan, PR China. The cells of strain REN37 was Gram-negative and aerobic. The cellular morphology exhibited rod-shaped cells without flagellum, displaying non-motility.

Mechanical Properties and Strength Criteria of Hydrate-Bearing Sediments Considering Clay Minerals.

Understanding the effect of clay on the mechanical properties and strength criteria of hydrate-bearing sediments (HBS) is essential for evaluating the safety of clay-rich reservoirs. In this study, a series of triaxial shear tests were conducted to investigate the impacts of clay type and content on the mechanical behavior of I-HBS (hydrate-bearing sediments containing illite) and M-HBS (hydrate-bearing sediments containing montmorillonite). The findings reveal that M-HBS exhibit greater susceptibility to strain hardening compared to I-HBS, accompanied by more extensive volume deformation, and both strain hardening and shear shrinkage intensify with increasing clay content.

Basic public service and residents' travel carbon time intensity: Impact and mechanism.

Investigating demand-side emission reduction through individual behavior and public infrastructure remains a focal point, yet existing studies lack a temporal perspective on their relationship. This study introduces the concept of carbon time intensity (CTI), which refines carbon emission analysis from total quantity to temporal structure, aiming to deepen the understanding of demand-side mitigation through an integrated spatiotemporal framework. This study, drawing on data from the 2021 China Time Use Survey and Household Finance Survey, investigates the mechanisms by which urban basic public service (BPS) affect residents' travel carbon time intensity (TCTI).

ABA-activated low-nanomolar Ca-CPK signalling controls root cap cycle plasticity and stress adaptation.

Abscisic acid (ABA) regulates plant stress adaptation, growth and reproduction. Despite extensive ABA-Ca signalling links, imaging ABA-induced increases in Ca concentration has been challenging, except in guard cells. Here we visualize ABA-triggered [Ca] dynamics in diverse organs and cell types of Arabidopsis thaliana using a genetically encoded Ca ratiometric sensor with a low-nanomolar Ca-binding affinity and a large dynamic range.

A 6-Month Randomized Controlled Trial to Measure the Efficacy of a Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) on Dental Plaque and Gingivitis.

Background: The objective of this randomized controlled trial was the comparison of a stannous fluoride (SnF2) dentifrice stabilized with nitrate and phosphates (test) to a regular fluoride dentifrice (negative control) for the control of plaque and gingivitis over 6 months.

Methods: A total of 80 adult participants were enrolled in this study that was conducted in Loma Linda, California. After randomization and blinding of study personnel and patients, enrolled participants were provided instructions for the use of their assigned dentifrice.

Colorimetric Thermography by a Long-Infrared Dual-Band Metalens.

Infrared (IR) radiation thermography is extensively utilized in diverse fields due to its non-contact capability. Nevertheless, its effectiveness is often compromised by the significant emissivity variations among different objects, limiting its application to specific setups or focused object types. Colorimetric thermography is introduced as an alternative emissivity-independent method of radiation thermometry.

Physiologically Based Pharmacokinetic Modeling to Assess Ritonavir-Digoxin Interactions and Recommendations for Co-Administration Regimens.

Background: Digoxin is a commonly used cardiac glycoside drug in clinical practice, primarily transported by P-glycoprotein (P-gp) and susceptible to the influence of P-gp inhibitors/inducers. Concurrent administration of ritonavir and digoxin may significantly increase the plasma concentration of digoxin. Due to the narrow therapeutic window of digoxin, combined use may lead to severe toxic effects.

In situ synthetic C encapsulated δ-MnO with O vacancies: A versatile programming in bio-engineering.

In this study, we successfully synthesized a δ-MnO cathode with O vacancies, encapsulated by C derived from pyromellitic acid, using a facile hydrothermal method followed by annealing in an Ar atmosphere. The cathode's structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product ZnSO(OH)·4HO, regulating the Mn valence state, and suppressing the Jahn-Teller effect through the synergy of C encapsulation and O vacancies. This results in remarkable electrochemical performance, including a large capacity of 421.

Traditional Chinese Medicine and Headache Disorders-A Review of Categorization and Selected Therapeutic Approaches.

Headaches have emerged as a prevailing global health concern, impacting millions of individuals and posing challenges to public health care systems. With an escalating number of patients seeking complementary therapies to attain a more holistic approach for headaches, Traditional Chinese Medicine has gained significant popularity. It plays a pivotal role in advancing the safeguarding of health and the alleviation of prevalent, recurrent, and complex medical conditions.

CellCircLoc: Deep Neural Network for Predicting and Explaining Cell Line-Specific CircRNA Subcellular Localization.

The subcellular localization of circular RNAs (circRNAs) is crucial for understanding their functional relevance and regulatory mechanisms. CircRNA subcellular localization exhibits variations across different cell lines, demonstrating the diversity and complexity of circRNA regulation within distinct cellular contexts. However, existing computational methods for predicting circRNA subcellular localization often ignore the importance of cell line specificity and instead train a general model on aggregated data from all cell lines.

Prognostic nomogram model based on quantitative metrics of subregions surrounding residual cavity in glioblastoma patients.

Background: The hyperintensity area surrounding the residual cavity on postoperative fluid-attenuated inversion recovery (FLAIR) image is a potential site for glioblastoma (GBM) recurrence. This study aimed to develop a nomogram using quantitative metrics from subregions of this area, prior to chemoradiotherapy (CRT), to predict early GBM recurrence.

Methods: Adult patients with GBM diagnosed between October 2018 and October 2022 were retrospectively analyzed.

A quantitative model using multi-parameters in dual-energy CT to preoperatively predict serosal invasion in locally advanced gastric cancer.

Objectives: To develop and validate a quantitative model for predicting serosal invasion based on multi-parameters in preoperative dual-energy CT (DECT).

Materials And Methods: A total of 342 LAGC patients who underwent gastrectomy and DECT from six centers were divided into one training cohort (TC), and two validation cohorts (VCs). Dual-phase enhanced DECT-derived iodine concentration (IC), water concentration, and monochromatic attenuation of lesions, along with clinical information, were measured and collected.