Effects of ambient temperature on mental and neurological conditions in older adults: A systematic review and meta-analysis.

Background: Emerging research has suggested a link between ambient temperature and mental and neurological conditions such as depression and dementia. This systematic review aims to summarize the epidemiological evidence on the effects of ambient temperature on mental and neurological conditions in older adults, who may be more vulnerable to temperature-related health effects compared to younger individuals.

Methods: A systematic search was conducted in PubMed, Ovid/Embase, Web of Science, and Ovid/PsycINFO on July 17, 2023, and updated on July 31, 2024.

GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4.

Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy characterized by dysregulated cellular metabolism leading to aberrant glucose metabolism, fatty acid accumulation, and excessive reactive oxygen species production. ccRCC cells exhibit an augmented oxidative stress response. Complex interactions between iron metabolism and lipid homeostasis in ccRCC cells require a counteracting response that enables ferroptosis evasion and survival maintenance.

Delineating Urbanicity and Rurality: Impact on Environmental Exposure Assessment.

Environmental exposures and their health impacts can vary substantially between urban and rural areas. However, different methods for classifying these areas could lead to inconsistencies in environmental exposure and health studies, which are often overlooked. We constructed different urban/rural classification systems based on multiple population-based (e.

Temperature, Crime, and Violence: A Systematic Review and Meta-Analysis.

Background: Heat is known to affect many health outcomes, but more evidence is needed on the impact of rising temperatures on crime and/or violence.

Objectives: We conducted a systematic review with meta-analysis regarding the influence of hot temperatures on crime and/or violence.

Methods: In this systematic review and meta-analysis, we evaluated the relationship between increase in temperature and crime and/or violence for studies across the world and generated overall estimates.

High-resolution greenspace dynamic data cube from Sentinel-2 satellites over 1028 global major cities.

Greenspace, offering multifaceted ecological and socioeconomic benefits to the nature system and human society, is integral to the 11 Sustainable Development Goal pertaining to cities and communities. Spatially and temporally explicit information on greenspace is a premise to gauge the balance between its supply and demand. However, existing efforts on urban greenspace mapping primarily focus on specific time points or baseline years without well considering seasonal fluctuations, which obscures our knowledge of greenspace's spatiotemporal dynamics in urban settings.

A systematic review of animal feeding operations including concentrated animal feeding operations (CAFOs) for exposure, health outcomes, and environmental justice.

Background: Despite growing literature on animal feeding operations (AFOs) including concentrated animal feeding operations (CAFOs), research on disproportionate exposure and associated health burden is relatively limited and shows inconclusive findings.

Objective: We systematically reviewed previous literature on AFOs/CAFOs, focusing on exposure assessment, associated health outcomes, and variables related to environmental justice (EJ) and potentially vulnerable populations.

Methods: We conducted a systematic search of databases (MEDLINE/PubMed and Web of Science) and performed citation screening.

Unraveling near real-time spatial dynamics of population using geographical ensemble learning.

Dynamic gridded population data are crucial in fields such as disaster reduction, public health, urban planning, and global change studies. Despite the use of multi-source geospatial data and advanced machine learning models, current frameworks for population spatialization often struggle with spatial non-stationarity, temporal generalizability, and fine temporal resolution. To address these issues, we introduce a framework for dynamic gridded population mapping using open-source geospatial data and machine learning.

Wildfire smoke exposure during pregnancy and perinatal, obstetric, and early childhood health outcomes: A systematic review and meta-analysis.

Background: Maternal exposure to air pollution during pregnancy is associated with adverse birth outcomes, although less is known for wildfire smoke. This systematic review evaluated the association between maternal exposure to wildfire smoke during pregnancy and the risk of perinatal, obstetric, and early childhood health outcomes.

Methods: We searched CINAHL Complete, Ovid/EMBASE, Ovid/MEDLINE, ProQuest, PubMed, Scopus, Web of Science, and Google Scholar to identify relevant epidemiological observational studies indexed through September 2023.

Ultrafast Antisolvent Growth of Single-Crystal CsPbBr Microcavity for Whispering-Gallery-Mode Lasing.

In recent years, all-inorganic cesium lead bromide (CsPbBr) perovskites have garnered considerable attention for their prospective applications in green photonics and optoelectronic devices. However, the development of efficient and economical methods to obtain high-quality micron-sized single-crystalline CsPbBr microplatelets (MPs) has become a challenge. Here, we report the synthesis of CsPbBr MPs on Si/SiO substrate by optimizing the ultrafast antisolvent method (FAS).

CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9.

Background: In many solid tumors, CD44 has been identified as a cancer stem cell marker as well as an important molecular in cancer progression and metastasis, making it attractive for potential therapeutic applications. However, our knowledge of the biological function and mechanism of CD44 in clear cell renal cell carcinoma (ccRCC) is limited.

Methods: In this study, the expression, prognostic values and functional enrichment analysis of CD44 in ccRCC were analyzed using public databases.

Mid-infrared carbon isotope spectrum logging system combined with a thermostat of optical subsystem for high-precision detection of isotope ratio.

In the process of oil and gas exploration and development, carbon isotope ratio can reflect the maturity of oil and gas and predict the recovery factor, and the isotope ratio in the composition of shale gas is particularly important. Thus, a carbon isotope spectrum logging system was designed and exploited based on tunable diode laser absorption spectroscopy (TDLAS) technology under the fundamental frequency absorption band of CO and CO molecules, and a quantum cascade laser (QCL) with center wavelength of 4.35 μm was applied.

ATAD2 promotes glycolysis and tumor progression in clear cell renal cell carcinoma by regulating the transcriptional activity of c-Myc.

Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urogenital tract. Given that ccRCC is often resistant to radiotherapy and traditional chemotherapy, the clinical treatment of patients with ccRCC remains a challenge. The present study found that ATAD2 was significantly upregulated in ccRCC tissues.

Spatiotemporally continuous estimates of daily 1-km PM concentrations and their long-term exposure in China from 2000 to 2020.

Monitoring long-term variations in fine particulate matter (PM) is essential for environmental management and epidemiological studies. While satellite-based statistical/machine-learning methods can be used for estimating high-resolution ground-level PM concentration data, their applications have been hindered by limited accuracy in daily estimates during years without PM measurements and massive missing values due to satellite retrieval data. To address these issues, we developed a new spatiotemporal high-resolution PM hindcast modeling framework to generate the full-coverage, daily, 1-km PM data for China for the period 2000-2020 with improved accuracy.

L1CAM deployed perivascular tumor niche promotes vessel wall invasion of tumor thrombus and metastasis of renal cell carcinoma.

The survival of tumor cells in the bloodstream, and vasculature adhesion at metastatic sites are crucial for tumor metastasis. Perivascular invasion aids tumor cell self-renewal, survival, and formation of metastases by facilitating readily available oxygen, nutrients, and endothelial-derived paracrine factors. Renal cell carcinoma (RCC) is among the most prevalent tumors of the urinary system, and the formation of venous tumor thrombus (VTT) is a characteristic feature of RCC.

TPM2 attenuates progression of prostate cancer by blocking PDLIM7-mediated nuclear translocation of YAP1.

Background: Prostate cancer (PCa) is a common malignant tumor of the genitourinary system. Clinical intervention in advanced PCa remains challenging. Tropomyosins 2 (TPM2) are actin-binding proteins and have been found as a biomarker candidate for certain cancers.

The temporal trend of disease burden attributable to metabolic risk factors in China, 1990-2019: An analysis of the Global Burden of Disease study.

Background And Aims: The disease burden attributable to metabolic risk factors is rapidly increasing in China, especially in older people. The objective of this study was to (i) estimate the pattern and trend of six metabolic risk factors and attributable causes in China from 1990 to 2019, (ii) ascertain its association with societal development, and (iii) compare the disease burden among the Group of 20 (G20) countries.

Methods: The main outcome measures were disability-adjusted life-years (DALYs) and mortality (deaths) attributable to high fasting plasma glucose (HFPG), high systolic blood pressure (HSBP), high low-density lipoprotein (HLDL) cholesterol, high body-mass index (HBMI), kidney dysfunction (KDF), and low bone mineral density (LBMD).

Comparative analysis of surgical and oncologic outcomes of robotic, laparoscopic and open radical nephrectomy with venous thrombectomy: a propensity-matched cohort study.

Objective: To provide insight into the surgical and oncological outcomes of robotic, laparoscopic and open radical nephrectomy with venous thrombectomy (RALRN-VT, LRN-VT, ORN-VT) in patients with renal tumor and venous thrombus.

Materials And Methods: A propensity-matched retrospective cohort study containing 324 patients with renal tumor and venous thrombus from January 2014 to August 2021 was analyzed. We compared surgical outcomes and we used the Kalan-Meier method to assess the overall survival (OS), tumor-specific survival (TSS), metastasis-free survival (MFS) and local recurrence-free survival (LRFS).

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma.

Radioresistance is a principal culprit for the failure of radiotherapy in hepatocellular carcinoma (HCC). Insights on the regulation genes of radioresistance and underlying mechanisms in HCC are awaiting for profound investigation. In this study, the suppressor of cytokine signaling 2 (SOCS2) were screened out by RNA-seq and bioinformatics analyses as a potential prognosis predictor of HCC radiotherapy and then were determined to promote radiosensitivity in HCC both in vivo or in vitro.

Contrasting inequality in human exposure to greenspace between cities of Global North and Global South.

The United Nations specified the need for "providing universal access to greenspace for urban residents" in the 11th Sustainable Development Goal. Yet, how far we are from this goal remains unclear. Here, we develop a methodology incorporating fine-resolution population and greenspace mappings and use the results for 2020 to elucidate global differences in human exposure to greenspace.

Performance of a Mid-Infrared Sensor for Simultaneous Trace Detection of Atmospheric CO and NO Based on PSO-KELM.

In this article, a field deployable sensor was developed using a self-developed 4.58-µm continuous wave quantum cascade laser (CW-QCL) for the simultaneous detection of carbon monoxide (CO) and nitrous oxide (NO), both of which have strong fundamental absorption bands in this waveband. The sensor is based on tunable diode laser absorption spectroscopy (TDLAS) technology, which combined a multi-pass gas cell (MPGC) with a 41 m optical path length to achieve high-precision detection.

Irradiation combined with PD-L1 and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.

Radiotherapy combined with immune checkpoint blockade has gradually revealed the superiority in the antitumor therapy; however, the contribution of host PD-L1 remains elusive. In this study, we found that the activation of CD8 T cells was strikingly increased in both irradiated PD-L1-expressing primary tumor and distant non-irradiated syngeneic tumor in PD-L1-deficient mouse host, and thus enhanced radiation-induced antitumor abscopal effect (ATAE) by activating cGAS-STING pathway. Notably, the autophagy inhibitors distinctively promoted dsDNA aggregation in the cytoplasm and increased the release of cGAS-STING-regulated IFN-β from irradiated cells, which further activated bystander CD8 T cells to release IFN-γ and contributed to ATAE.

Spatial uncertainty and environment-health association: An empirical study of osteoporosis among "old residents" in public housing estates across a hilly environment.

Background: Built environment can influence physical conditions of older adults (e.g. osteoporosis).

Beyond green environments: Multi-scale difference in human exposure to greenspace in China.

Greenspace exposure metrics can allow for comparisons of green space supply across time, space, and population groups, and for inferring patterns of variation in opportunities for people to enjoy the health and recreational benefits of nearby green environments. A better understanding of greenspace exposure differences across various spatial scales is a critical requirement for lessening environmental health disparities. However, existing studies are typically limited to a single city or across selected cities, which severely limits the use of results in measuring systemic national and regional scale differences that might need policy at above individual city planning level.

Realizing Single Chip White Light InGaN LED via Dual-Wavelength Multiple Quantum Wells.

Dual-wavelength multiple quantum wells (MQWs) have great potential in realizing high quality illumination, monolithic micro light-emitting diode (LED) displays and other related fields. Here, we demonstrate a single chip white light indium gallium nitride (InGaN) LED via the manipulation of the dual-wavelength MQWs. The MQWs contain four pairs of blue light-emitting MQWs and one pair of green light-emitting QW.