The recent advance of PROTACs targeting BCR-ABL for the treatment of chronic myeloid leukemia.

The chronic myeloid leukemia is a malignant hematopoietic disorder in which the BCR-ABL kinase has been identified as the causative protein. The inhibitors targeting BCR-ABL kinase have been extensively employed in clinical management of chronic myeloid leukemia, significantly enhancing survival rates and prognosis for patients. Despite the extensive utilization of 1st to 4th generation BCR-ABL inhibitors in clinical therapy, the emergence of drug-resistant mutations necessitates an urgent quest for novel therapeutic strategies.

Anti-Mold Activities of Cationic Oligomeric Surfactants.

Molds are persistent and harmful but receive far less research attention compared with pathogenic bacteria. With the increase in microbial resistance to single-chain surfactant antimicrobial agents, it is crucial to investigate how surfactant structures affect the antimicrobial activity of surfactants. Here, we have studied the antimold efficacy of a series of oligomeric cationic quaternary ammonium surfactants at varying oligomerization levels with or without dynamic covalent imine bonds.

Modification mechanism of potato protein by twin-screw extrusion from the perspective of temperature variation.

Potato protein has attracted much attention due to its unique nutritional and structural properties. In this study, the twin-screw extrusion technology was employed to modify potato protein, while the modification mechanism was investigated from the perspective of temperature variation. Results indicated that extruded potato protein (EPP) led to the extremely significantly decreased surface hydrophobicity (1350 to 307-396) and foaming capacity (41.

Extracellular Mitochondrial-Derived Vesicles Affect the Progression of Diabetic Foot Ulcer by Regulating Oxidative Stress and Mitochondrial Dysfunction.

Diabetic foot ulcer (DFU) is a common and severe complication of diabetes mellitus, the etiology of which remains insufficiently understood, particularly regarding the involvement of extracellular vesicles (EVs). In this study, nanoflow cytometry to detect EVs in DFU skin tissues is used and found a significant increase in the Translocase of Outer Mitochondrial Membrane 20 (TOM20) mitochondrial-derived vesicles (MDVs). The role of MDVs in DFU is yet to be reported.

pH-regulated preparation and structural characterization of non-covalent complexes of soybean isolate proteins with different charged polysaccharides.

Soybean protein isolate (SPI) exhibits limited functional properties in processing applications due to environmental stressors such as pH, salt ion, and temperature. The present study was devoted to exploring the non-covalent assembly of SPI with chitosan (CS), glucan (GL) and sodium alginate (SA) under different pH conditions. At a fixed mixing ratio (1:1), the phase behavior, protein solubility, and surface hydrophobicity (H) of the resulting protein-polysaccharide complexes (PPCs) exhibited great differences due to the diversity of polysaccharide charge density and structure.

Spatiotemporal evolution of landscape ecological risk and its driving factors of the Beijing-Tianjin-Hebei major mineral belt, 1985-2022.

The Beijing-Tianjin-Hebei major mineral belt represents a significant economic development area in China. Effective monitoring and assessment of the regional landscape ecological risk can provide a scientific basis for an ecological protection strategy for the environmental protection of the Beijing-Tianjin-Hebei major mineral belt. In this study, a landscape ecological risk index was constructed based on land use/land cover, and the spatial and temporal variations of landscape ecological risk were subsequently analyzed.

3D printing of wearable sensors with strong stretchability for myoelectric rehabilitation.

Myoelectric biofeedback (EMG-BF) is a widely recognized and effective method for treating movement disorders caused by impaired nerve function. However, existing EMG-feedback devices are almost entirely located in large medical centers, which greatly limits patient accessibility. To address this critical limitation, there is an urgent need to develop a portable, cost-effective, and real-time monitoring device that can transcend the existing barriers to the treatment of EMG-BF.

A combined noise source model based on vertical coherence to quantify the proportions of two types of noise power.

With the vigorous development of maritime trade, the frequency band from 100 to 1500 Hz of shallow-sea ambient noise is not only affected by surface wind-induced noise but also the contribution of ship noise. Shallow-sea ambient noise can be described by a linear combination of surface wind-induced noise sources and ship noise sources. By using the correspondence between the real part of the vertical coherence and vertical energy flux, this work establishes a combined noise source model based on vertical coherence.

How Marine Megabenthos Fauna Responds to River Discharge and Artificial Flood in Large River Estuary.

Estuaries are ecologically sensitive areas influenced by river regulation. Knowledge of how marine megabenthos responds to river regulation and artificial flooding events remains limited. The study aims to provide a comprehensive understanding of the impacts of river regulation on marine megabenthic fauna.

A Cerium Oxide Loaded Hyaluronic Acid Nanosystem Remits Glucose Oxidative Stress-Induced Odontoblasts Mitochondrial Apoptosis through Regulation of PGAM5 Pathway.

Diabetes mellitus (DM) induced mitochondrial oxidative stress (OS) can lead to severe injury of dental pulp. The cerium oxide nanoparticles (CNP) have been proven to have excellent antioxidative activity. However, whether CNP can relieve dental pulp damage caused by DM and the underlying mechanisms remain unclear.

Early Alpha-Fetoprotein Response Predicts Sustained Tumor Response Following Immune Checkpoint Inhibitors Combined with Targeted Therapy in Liver Cancer.

Although immune checkpoint inhibitors (ICI) have revolutionized liver cancer treatment, some patients experience early tumor progression after therapy, missing the window for other potential treatments, such as neoadjuvant therapy. Therefore, identifying the predictive factors for early progression is critical for timely therapeutic adjustment and the optimization of patient outcomes. This retrospective study enrolled patients with liver cancer who received their first ICI combined with targeted therapy at the Fifth Medical Center of the PLA General Hospital between June 2022 and December 2023.

Compressible, anti-fatigue, extreme environment adaptable, and biocompatible supramolecular organohydrogel enabled by lignosulfonate triggered noncovalent network.

Achieving a synergy of biocompatibility and extreme environmental adaptability with excellent mechanical property remains challenging in the development of synthetic materials. Herein, a "bottom-up" solution-interface-induced self-assembly strategy is adopted to develop a compressible, anti-fatigue, extreme environment adaptable, biocompatible, and recyclable organohydrogel composed of chitosan-lignosulfonate-gelatin by constructing noncovalent bonded conjoined network. The ethylene glycol/water solvent induced lignosulfonate nanoparticles function as bridge in chitosan/gelation network, forming multiple interfacial interactions that can effectively dissipate energy.

Rapid quantitative PCR on tongue swabs for pulmonary tuberculosis in adults: a prospective multicentre study.

Background: Tuberculosis (TB) remains a major cause of infectious disease mortality globally, with significant underdiagnosis perpetuating transmission. Tongue swab analysis has emerged as a promising non-invasive method for pulmonary TB diagnosis. This study evaluates the diagnostic accuracy of the TB-EASY quantitative PCR (qPCR) assay using tongue swab specimens.

Integrating hypoxanthine and K value for reliable and rapid freshness assessment in marine fish.

This study aimed to explore the relationship between hypoxanthine (Hx) levels and freshness indicators in three kinds of fish samples during storage for 7 days at 4 °C to determine the Hx levels indicating freshness. The total volatile basic nitrogen (TVBN) was tested using the semi-micro Kjeldahl method, and Hx level and K value were measured using high-performance liquid chromatography (HPLC). During storage, Hx levels, TVBN, and K values increased, and distinct patterns were observed between Hx and TVBN in three fish samples.

Ultrafine metal-organic framework @ graphitic carbon with MoS-CNTs nanocomposites as carbon-based electrochemical sensor for ultrasensitive detection of catechin in beverages.

GO/Co-MOF/PPy-350 (GPC-350) was synthesized by in situ growth of ultrafine Co-MOF on graphene oxide (GO), followed by encapsulation with polypyrrole (PPy) and calcination at 350.0℃. Meanwhile, MoS-MWCNTs (MoS-CNTs) were produced via the in situ synthesis of MoS within multi-walled carbon nanotubes (MWCNTs).

Facile On-Substrate Fabrication of Silver Coordination Polymer Nanowires for Sustainable and Efficient Water Disinfection.

Silver, as the oldest antibacterial material, has been almost replaced by other alternatives for its insufficient activity or potential side-effects on the ecosystem due to the over-release of Ag ions (Ag). Herein, a facile and general strategy is developed to on-substrate fabricate silver coordination polymer nanowire arrays (Ag CPN) by simply immersing Ag-containing substrates into cationic surfactant solution at room temperature. Such a Ag CPN not only provides high-surface-area nano-biointerfaces for destroying microorganisms via physicomechanical interactions but also acts as a safe Ag reservoir, steadily releasing Ag at a relatively high but safe level (∼40 ppb, but lower than the safe level of 100 ppb).

Validation of a brief food parenting measure for fathers: A test of factorial validity, measurement invariance, internal reliability, and concurrent validity.

Fathers are underrepresented in food parenting research partly due to the lack of succinct, theory-informed, and father-mother equivalent food parenting measurement tools. To address this, we 1) tested the factorial validity of a brief food parenting measure utilizing a subset of items from the Comprehensive Feeding Practices Questionnaire (CFPQ) to represent coercive control, structure, and autonomy support, 2) assessed the extent to which the brief tool works similarly in fathers and mothers (i.e.

Versatile fluorescence biosensors based on CRISPR/Cas12a for determination of site-specific DNA methylation from blood and tissues.

The identification of DNA methylation at specific sites is crucial for the early detection of cancer since DNA methylation is intimately associated to the occurrence and development of cancer. Herein, two types of sensors that can detect site-specific DNA methylation were developed to meet practical requirements using methylation sensitive restriction endonuclease and CRISPR/Cas12a. To accomplish rapid detection of target, an AciI-mediated CRISPR/Cas12a assay was developed by coupling AciI to recognize DNA methylation with Cas12a to identify site-specific DNA.

Large Band Splitting in g-Wave Altermagnet CrSb.

Altermagnetism (AM), a newly discovered magnetic state, ingeniously integrates the properties of ferromagnetism and antiferromagnetism, representing a significant breakthrough in the field of magnetic materials. Despite experimental verification of some typical AM materials, such as MnTe and MnTe_{2}, the pursuit of AM materials that feature larger spin splitting and higher transition temperature is still essential. Here, our research focuses on CrSb, which possesses Néel temperature of up to 700 K and giant spin splitting near the Fermi level (E_{F}).

Insights into the influence of organic and salinity on the two-stage partial nitritation/anammox process in treating food waste digestate.

Food waste digestate (FWD), which contains significant levels of ammonium, organic matter, and salinity, can interfere with treatment performance of the anammox process. In this study, a two-stage partial nitritation/anammox (PN/A) process was established to investigate nitrogen removal and microbial response in treating FWD at a nitrogen loading rate (NLR) of 0.27 ± 0.

End-point RPA-CRISPR/Cas12a-based detection of Enterocytozoon bieneusi nucleic acid: rapid, sensitive and specific.

Enterocytozoon bieneusi is a common species of microsporidia that infects humans and animals. Current methods for detecting E. bieneusi infections have trade-offs in sensitivity, specificity, simplicity, cost and speed and are thus unacceptable for clinical application.

Molecular mechanisms of tetrabromobisphenol A (TBBPA) toxicity: Insights from various biological systems.

Tetrabromobisphenol A (TBBPA) is a ubiquitous brominated flame retardant extensively incorporated into a wide range of products. As its utilization has escalated, its environmental exposure risks have concomitantly increased. The molecular properties of TBBPA allow it to persist in the environment and within organisms.