Translating primary care to telehealth: analysis of in-person paediatric consultations and role of the carers.

Background: The usage of telehealth in general practice (GP) has risen substantially ever since the COVID-19 pandemic. Over this timeframe, telehealth has provided care for all patient demographics, including the paediatric population (aged<18). However, the translatability of telehealth (ie, whether in-person tasks can be supported remotely via telehealth) rarely considers the paediatric population or their carers.

Exploring the impact of fulvic acid on electrochemical hydrogen-driven autotrophic denitrification system: Performance, microbial characteristics and mechanism.

In this study, the effect of modulating fulvic acid (FA) concentrations (0, 25 and 50 mg/L) on nitrogen removal in a bioelectrochemical hydrogen autotrophic denitrification system (BHDS) was investigated. Results showed that FA increased the nitrate (NO-N) removal rate of the BHDSs from 37.8 to 46.

Translating in-person care to telehealth: analysis of GP consultations on musculoskeletal conditions.

Background: The COVID-19 pandemic led to a rapid transition to telehealth particularly in general practice (GP) where continuous care for chronic conditions such as musculoskeletal (MSK) is provided.

Aim: To determine the appropriateness of telehealth for MSK by identifying whether in-person tasks can be supported remotely via telehealth.

Design & Setting: This study is a secondary analysis of the HaRI dataset.

Enhanced aerobic granular sludge by thermally-treated dredged sediment in wastewater treatment under low superficial gas velocity.

The positive contributions of carriers to aerobic granulation have been wildly appreciated. In this study, as a way resource utilization, the dredged sediment was thermally-treated to prepared as carriers to promote aerobic granular sludge (AGS) formation and stability. The system was started under low superficial gas velocity (SGV, 0.

Symmetry in thermal cycles and processes.

Symmetry analysis is a cutting-edge research approach in physics, yet its application in macroscopic energy systems remains limited. This study demonstrates its potential to provide valuable insights for a deeper understanding and development of thermodynamic cycles. This article first studies the symmetry of the proposed - diagrams and finds rich symmetries including reflection symmetry, translation symmetry, and rotational symmetry within Carnot cycles.

Improvement of a Model of Brain Death for Transplant-Associated Studies in Rats.

Background: The most common method of inducing brain death in rats is inflating an intracranially placed balloon of a Fogarty catheter inserted through a burr hole. However, because of the poor controllability of balloon position, the standardization and stability of the model are compromised. This study examined an improved technique in which the balloon is placed and fixed through double holes.

The efficacy of adjuvant chemotherapy in patients with different midpoint-radiotherapy Epstein-Barr virus DNA plasma loads.

Objectives: This study aimed to evaluate the efficacy of adjuvant chemotherapy (AC) in patients with different midpoint-radiotherapy (mid-RT) Epstein-Barr virus (EBV) DNA plasma loads for locoregionally advanced nasopharyngeal carcinoma (NPC), and to provide decision-making regarding the use of AC.

Materials And Methods: A total of 675 consecutive patients diagnosed with stage III-IVa NPC were enrolled in this study. All patients underwent concurrent chemoradiotherapy (CCRT), either with or without induction chemotherapy or AC, or a combination of both.

Learning and depicting lobe-based radiomics feature for COPD Severity staging in low-dose CT images.

Background: Chronic obstructive pulmonary disease (COPD) is a prevalent and debilitating respiratory condition that imposes a significant healthcare burden worldwide. Accurate staging of COPD severity is crucial for patient management and treatment planning.

Methods: The retrospective study included 530 hospital patients.

Novel method for recovering valuable metals from Sn ash: Vacuum carbothermal reduction-directional condensation.

Sn ash recycling is an industry with positive development prospects, as it provides better-protected resources, promotes sustainable development, and lays a solid foundation for future development. In this study, an innovative vacuum carbothermal reduction-directional condensation process was developed. The thermodynamic analysis results indicated that the initial reaction pressure and temperature for the carbothermal reduction of the system was 1-10 Pa and 998-1063 K, respectively.

Exogenous hydrogen sulfide prevents SOD2 degradation to safeguard renal function in diabetic kidney disease.

Diabetic kidney disease (DKD) is a major contributor to chronic kidney disease. Hydrogen sulfide (HS) serves as an endogenous gaseous signaling molecule capable of safeguarding renal function within the context of DKD. However, the underlying mechanisms need to be elucidated.

NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP.

The ribosome-associated protein quality control (RQC) pathway acts as a translational surveillance mechanism to maintain proteostasis. In mammalian cells, the cytoplasmic RQC pathway involves nuclear export mediator factor (NEMF)-dependent recruitment of the E3 ligase Listerin to ubiquitinate ribosome-stalled nascent polypeptides on the lysine residue for degradation. However, the quality control of ribosome-stalled nuclear-encoded mitochondrial nascent polypeptides remains elusive, as these peptides can be partially imported into mitochondria through translocons, restricting accessibility to the lysine by Listerin.

Combating land degradation through human efforts: Ongoing challenges for sustainable development of global drylands.

Drylands, as highly vulnerable ecosystems, support environmental functions and human well-being. Nevertheless, widespread land degradation and desertification present significant global and regional environmental challenges, with limited consensus on their area and degree. This study used time-series vegetation productivity and meteorological data from 2000 to 2020 to quantify global land degradation trends and driving factors in drylands.

Efficient removal of tetracycline hydrochloride through novel Fe/BiOBr/BiWO photocatalyst prepared by dual-strategy under visible-light irradiation.

It is important to investigate whether combining two modification strategies has a synergistic effect on the activity of photocatalysts. In this manuscript, Fe-doped BiOBr/BiWO heterojunctions were synthesized by a one-pot solvothermal method, and excellent photocatalytic performance was obtained for the degradation of tetracycline hydrochloride (TCH) in water without the addition of surfactant. Combining experiments and characterization, the synergistic effect between Fe ion doping and the BiOBr/BiWO heterojunction was elucidated.

Growth Axis , , and Genes Express and Are Affected by the Injection of Exogenous Growth Hormone in .

In this study, to explore the effect of growth hormone changes on the related genes and regulatory roles of the turtle, PCR amplification, real-time fluorescence quantitative analysis, and enzyme cutting technology were used to clone and sequence the () gene, (), and () sequence of . The effects of human growth hormone on the mRNA expression of growth-axis-related genes , , and in different sexes were observed. The study of the gene in turtles using real-time fluorescence quantitative PCR showed that the gene was mainly expressed in the nervous system and the digestive system, with the highest expression found in the brain, while the gene and the gene were expressed in all tissues of .

Development of Adjustable High- to Low-Adhesive Superhydrophobicity Using Aligned Electrospun Fibers.

Superhydrophobic surfaces based on electrospun fibrous structures exhibit advantages of additive manufacturing and enable the passage of gases. Compared to randomly deposited fibers, directionally aligned fibers improve the control of surface wetting by a specified fiber orientation and predictable liquid-fiber contact interface. In this article, we create superhydrophobicity with adjustable adhesion based on the understanding of droplet wetting behavior on directionally aligned fibers.

Application of skeleton builders to sludge dewatering and disposal: A critical review.

With the development of cities and population, the production of sludge is increasing annually. It has become an unavoidable challenge to achieve sludge dewatering and disposal by a cost-effective, efficient and safe process. In this work, firstly, the factors limiting sludge dewatering are reviewed in terms of moisture distribution, sludge concentration, organic matter content, electronegativity, floc strength, and extracellular polymers (EPS).

Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial.

Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for refractory recurrent/metastatic nasopharyngeal carcinoma (RM-NPC). We conducted a phase 2 trial to evaluate the safety and activity of camrelizumab plus apatinib in platinum-resistant (cohort 1, NCT04547088) and PD-1 inhibitor resistant NPC (cohort 2, NCT04548271). Here we report on the primary outcome of objective response rate (ORR) and secondary endpoints of safety, duration of response, disease control rate, progression-free survival, and overall survival.

Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of in the Treatment of Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints associated with systemic comorbidities. is regarded as an effective traditional Chinese medicine (TCM) for the treatment of RA.

Materials And Methods: Based on network pharmacology and Gene Expression Omnibus (GEO) database, 33 RA-related differentially-expressed genes (DEGs) targeting active compounds of were initially screened in our investigation.

Methane emission reduction oriented extracellular electron transfer and bioremediation of sediment microbial fuel cell: A review.

Sediment is the internal and external source of water environment pollution, so sediment remediation is the premise of water body purification. Sediment microbial fuel cell (SMFC) can remove the organic pollutants in sediment by electroactive microorganisms, compete with methanogens for electrons, and realize resource recycling, methane emission inhibiting and energy recovering. Due to these characteristics, SMFC have attracted wide attention for sediment remediation.

Bayesian inference for survival prediction of childhood Leukemia.

Background: Childhood Leukemia is the most common type of cancer among children. Nearly 39% of cancer-induced childhood deaths are attributable to Leukemia. Nevertheless, early intervention has long been underdeveloped.

mRNA Turnover Protein 4 Is Vital for Fungal Pathogenicity and Response to Oxidative Stress in .

Ribosome assembly factors have been extensively studied in yeast, and their abnormalities may affect the assembly process of ribosomes and cause severe damage to cells. However, it is not clear whether mRNA turnover protein 4 (MRT4) functions in the fungal growth and pathogenicity in . Here, we identified the nucleus-located gene using reverse genetics, and found that knockdown of resulted in retard mycelia growth and complete loss of pathogenicity.

Recent advances in constructed wetlands methane reduction: Mechanisms and methods.

Constructed wetlands (CWs) are artificial systems that use natural processes to treat wastewater containing organic pollutants. This approach has been widely applied in both developing and developed countries worldwide, providing a cost-effective method for industrial wastewater treatment and the improvement of environmental water quality. However, due to the large organic carbon inputs, CWs is produced in varying amounts of CH and have the potential to become an important contributor to global climate change.