Publications by authors named "Yi-zhuo Zhao"
Article Synopsis
- The study focuses on predicting hypothyroidism in cancer patients undergoing treatment with immune checkpoint inhibitors (ICIs) using machine learning (ML) techniques.
- Researchers developed and tested several ML models, including logistic regression, random forest, support vector machine, and XGBoost, with XGBoost demonstrating the best predictive accuracy (AUC = 0.833).
- The findings suggest that an interpretable ML model can help identify patients at risk for hypothyroidism post-ICI treatment, with thyroid-stimulating hormone (TSH) being the key predictor, enhancing personalized treatment strategies.
Ethnopharmacological Relevance: Xihuang pill as a famous traditional Chinese formula has long been used as an adjuvant therapy for cancer.
Aim Of The Study: This study is aimed at summarizing recent advances in research of Xihuang pill's anti-cancer efficacies from the theoretical basis of traditional Chinese medicine, pharmacological activities, chemical components and its clinical application.
Materials And Methods: The literature information was obtained from several authoritative databases including PubMed, Embase, Cochrane Library, CNKI and Wan Fang before April 30, 2023.
The optimal pharmaceutical regimen for advanced thymic epithelial tumors (TETs) remains controversial when first-line chemotherapy fails. This retrospective study aims to evaluate the efficacy and safety of anlotinib treatment for patients with relapsed and refractory TETs. Patients with progressive disease after failure of platinum-based chemotherapy were enrolled in this study.
View Article and Find Full Text PDFG4-Tetra DNA Duplex Induce Lung Cancer Cell Apoptosis in A549 Cells.
Nanoscale Res Lett
December 2016
The specific DNA is typically impermeable to the plasma membrane due to its natural characters, but DNA tetra structures (DTNs) can be readily uptake by cells in the absence of transfection agents, providing a new strategy to deliver DNA drugs. In this research, the delivery efficiency of tetrahedral DNA nanostructures was measured on adenocarcinomic human alveolar basal epithelial (A549) cells via delivering AS1411 (G4). The DNA tetra-AS1411 complex was rapidly and abundantly uptake by A549 cells, and the induced apoptosis was enhanced.
View Article and Find Full Text PDFBackground: Sunitinib is an oral multitargeted tyrosine kinase inhibitor (TKI) exhibiting antiagiogenic and antitumor effects.
Objective: To evaluate the efficacy and potential toxicity of sunitinib therapy in advanced non-small cell lung cancer (NSCLC) patients in China.
Methods: From January 2009 to August 2011, 30 patients with stage IV NSCLC, who were pretreated with the epidermal growth factor receptor (EGFR)-TKIs and then received sunitinib, were retrospectively reviewed.
Objective: To analyze the efficacy and quality of life and safety for paclitaxel and carboplatin (TC) and TC combined with endostar in the treatment of advanced non-small cell lung cancer (NSCLC).
Methods: This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical study. A total of 126 cases of untreated advanced NSCLC were enrolled in this study.
Study Objectives: Recently, less invasive methods have emerged as potential alternatives for staging with tissue confirmation of suspected metastatic mediastinal lymph nodes in lung cancer. The objective of this review was to assess the overall diagnostic accuracy of EBUS-TBNA in detecting metastatic mediastinal lymph node in lung cancer with a meta-analysis.
Methods: The MEDLINE, EMBASE, Cancerlit and Cochrane Library database, from January 1995 to September 2008, were searched for studies evaluating EBUS-TBNA accuracy.