Optimizing antigen selection for the development of tuberculosis vaccines.

Tuberculosis (TB) remains a prevalent global infectious disease caused by genetically closely related tubercle bacilli in complex (MTBC). For a century, the Bacillus Calmette-Guérin (BCG) vaccine has been the primary preventive measure against TB. While it effectively protects against extrapulmonary forms of pediatric TB, it lacks consistent efficacy in providing protection against pulmonary TB in adults.

[Meteorological Impact Assessment of PM and O Complex Pollution in Key Regions of China Based on Meteorological Conditions Index].

Meteorological conditions play a key role in the occurrence and evolution of atmospheric complex pollution. Considering the different pollution formation mechanisms of PM and O, statistical calculation and in-depth learning methods were used to construct the PM and O meteorological condition indexes based on long-term pollution meteorological observation data. A research method was developed to study the meteorological characteristics and impact contribution of atmospheric complex pollution by using the meteorological condition index, and quantitative analysis of the distribution and variation of pollution excluding the influence of regional meteorological differences was also conducted.

Long-read Sequencing Data Reveals Dynamic Evolution of Mitochondrial Genome Size and the Phylogenetic Utility of Mitochondrial DNA in Hercules Beetles (Dynastes; Scarabaeidae).

The evolutionary dynamics and phylogenetic utility of mitochondrial genomes (mitogenomes) have been of particular interest to systematists and evolutionary biologists. However, certain mitochondrial features, such as the molecular evolution of the control region in insects, remain poorly explored due to technological constraints. Using a combination of long- and short-read sequencing data, we assembled ten complete mitogenomes from ten Hercules beetles.

Sustainable treatment of nitrate-containing wastewater by an autotrophic hydrogen-oxidizing bacterium.

Bacteria are key denitrifiers in the reduction of nitrate (NO -N), which is a contaminant in wastewater treatment plants (WWTPs). They can also produce carbon dioxide (CO) and nitrous oxide (NO). In this study, the autotrophic hydrogen-oxidizing bacterium sp TH20 was isolated for sustainable treatment of NO -N in wastewater.

[Analysis of Characteristics and Causes of a Typical Haze Pollution in Beijing in the Winter of 2019].

In order to study the pollution characteristics and causes of winter haze pollution in Beijing, a typical PM pollution process in Beijing in December 2019 was used as the analysis object using aerosol vertical detection data, boundary layer meteorological field and near-ground turbulence data, and the difference in haze. The characteristics of the pollution stage and the evolution of the physical and chemical characteristics of the boundary layer were comprehensively analyzed. The results showed that ① the pollution process in Beijing during the observation period lasted 5 d and experienced two generations and eliminations.

Maternal hypercholesterolemia exacerbates atherosclerosis lesions in female offspring through potentiating macrophage polarization toward an inflammatory M1 phenotype.

Maternal hypercholesterolemia induces early onset of cardiovascular diseases in offspring; however, its underlying mechanism remains poorly understood. We hypothesized that maternal hypercholesterolemia increases offspring susceptibility to atherosclerosis in adulthood through developmental modifications of macrophages. Female apolipoprotein E (ApoE)-deficient mice were fed a Western-type diet (WD) or a control diet (CD) prior to and throughout gestation and lactation.

The nonalcoholic fatty liver disease-like phenotype and lowered serum VLDL are associated with decreased expression and DNA hypermethylation of hepatic ApoB in male offspring of ApoE deficient mothers fed a with Western diet.

Increasing evidence indicates that the intra-uterine environment has consequences for later life. However, the mechanisms of this fetal programming remain unclear. We aimed to investigate the impact of diet-induced maternal hypercholesterolemia on the predisposition of offspring to nonalcoholic fatty liver diseases (NAFLD) and metabolic diseases and its underlying mechanisms.

Magnetic chitosan/sodium alginate gel bead as a novel composite adsorbent for Cu(II) removal from aqueous solution.

Using sodium alginate hydrogel as skeleton, in combination with chitosan and magnetic FeO, a new type of magnetic chitosan/sodium alginate gel bead (MCSB) was prepared. Adsorptive removal of Cu(II) from aqueous solutions was studied by using the MCSB as a promising candidate in environmental application. Different kinetics and isotherm models were employed to investigate the adsorption process.

Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.

Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L.

Study on Adsorption and Desorption Characteristics of Cd2+ and Cu2+ on the Surface Sediments of Sanhuhekou of Yellow River by Using ICP-MS.

In order to study the interaction mechanism between Cd2+, Cu2+ and surface sediments in the upper reaches of the Yellow River, the surface sediment of Sanhuhekou (YRSSM) was chosen as research object with inductively coupled plasma mass spectrometry (ICP-MS) as analysis method. The adsorption reaction condition such as liquid-solid ratio, reaction time and pH were optimized, and the adsorption and desorption characteristics of Cd2+ and Cu2+ onto the surface sediments under the optimized experimental conditions were studied. The results showed that the adsorption capacity of Cu2+ was greater than that of Cd2+, the equilibrium absorption capacity were 0.

[Functional analysis of a novel SCN5A mutation G1712C identified in Brugada syndrome].

Objective: To elucidate the molecular and electrophysiological mechanisms of Brugada syndrome through functional analysis of a novel SCN5A gene mutation G1712C.

Methods: A recombinant plasmid pRc View Article and Find Full Text PDF

Studied on Distribution and Heavy Metal Pollution Index of Heavy Metals in Water from Upper Reaches of the Yellow River, China.

In order to understand the spatial distribution and evaluate the pollution degree of heavy metals (As, Cd, Cr, Co, Cu, Mn, Ni, Pb, and Zn) in upper reaches of the Yellow River, surface water samples were collected from 12 selected sites during two field surveys in April 2014 (drought season) and October 2014 (normal season). The concentrations of heavy metals were determined using inductively coupled plasma mass spectrometry (ICP-MS) for spatial variation and heavy metal pollution index. The average concentrations of the metals in the drought season and normal season decreased respectively in the order: Cr (18.

[Eco-physiology and regulation of leaf senescence and maturity performance in cotton: A review].

Senescence is a natural termination process at the plant or organ level of cotton, leading to the inevitable end of the growth and development process. Maturity performance is termed as senescence performance and results of a cotton plant during boll opening, including normal maturity, premature senescence and late-maturity in cotton. Senescence and maturity performance are influenced by genotype and environment interactions.

In situ prepared polypyrrole for low humidity QCM sensor and related theoretical calculation.

In situ preparation of polypyrrole (Ppy) by photo-polymerization coated on a quartz crystal microbalance (QCM) as a low humidity sensor was reported. Different concentrations of Ppy films say 0wt.% (as blank), 0.

[The quality status of anesthetic units used in Shanghai and the supervision countermeasures].

Based on the testing results of samples, this article represents the safety status of anesthetic units used in Shanghai medical institutions. In order to guarantee the safety and efficacy of the anesthetic devices, the medical institutions should set up some effective management systems, the related government departments should immediately perfect their administration system and bring in the market-operated professional maintenance organizations.

[Expression of neutrophil adhesion molecule CD11b as an early diagnostic marker for neonatal sepsis].

Objective: Neonatal sepsis is a common disease and the sepsis-related mortality rate is still high. Until now, there has no ideal diagnostic marker to early identify neonatal sepsis. Expression of neutrophil adhesion molecule CD(11b) was showed as the earlier reaction to the infection/inflammation, and may be applied as an early diagnostic marker for sepsis.