[Analysis of Clinical Characteristics and Prognostic Risk Factors of HLH Children with Central Nervous System Involvement].

Objective: To investigate the clinical characteristics and prognostic risk factors of HLH children with central nervous system (CNS) involvement so as to provide more reference for further improving the prognosis of HLH children.

Methods: The clinical data of 45 HLH children with CNS involvement treated in our hospital from January 2006 to October 2016 were collected and analyzed retrospectively. The clinical characteristics of HLH children with CNS involvement were recorded, moreover the possible factors influencing the prognosis of HLH children with CNS involvement were analyzed using univariate and multivariate analysis through the establishment of Cox risk ratio model.

Photodynamic therapy in the treatment of xeroderma pigmentosum: A case report.

Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis that is often complicated by multiple skin tumours at exposed locations, which are difficult to treat. We report a case of a 12-year-old girl with XP treated with oral retinoic acid and photodynamic therapy (PDT) with good clinical results. She had an 8-year history of multiple skin lesions that first appeared on her nasal dorsum, but gradually increased in size and spread to her entire face, neck, and upper limbs.

Curative effect of methotrexate combined with teniposide in the treatment of primary central nervous system lymphoma.

The present study aimed to investigate the curative effect of high-dose methotrexate (HD-MTX) combined with teniposide (Vm26) vs. HD-MTX alone in the treatment of primary central nervous system lymphoma (PCNSL), in order to provide data for assisting decisions associated with clinical treatment. Data from 56 patients with PCNSL admitted in Shanghai Huashan Hospital (Shanghai, China) from January 2009 to December 2014 were included into the present study.

Association between fetal fraction at the second trimester and subsequent spontaneous preterm birth.

Objective: To evaluate the association between the fetal fraction of cell-free DNA at the second trimester and subsequent spontaneous preterm birth.

Methods: In this retrospective cohort study, data were collected from women with singleton pregnancies who underwent noninvasive prenatal testing at 14 to 25 weeks of gestation. The eligible patients were classified into three groups according to pregnancy outcome: birth at ≥37 weeks of gestation (term group), delivery at <34 weeks of gestation (early spontaneous preterm), and delivery at 34 to 36  weeks of gestation (late spontaneous preterm).

[Value of Analyzing Hemoglobin A by ROC Curve for Screening Thalassemia].

Objective: To investigate the value of hemoglobin A(HbA) for screening thalassemia.

Methods: A total of 2 000 adults' peripheral blood samples from Guangdong Women and Children Hospital from June 2013 to January 2014 were collected. The hemoglobin A (HbA) level was analyzed by the full automatic capillary electrophoresis technique, and the genotypes of thalassemia were detected.

Levels of anti-BP180 NC16A IgE do not correlate with severity of disease in the early stages of bullous pemphigoid.

Bullous pemphigoid (BP), a common autoimmune skin disease, is associated with IgG autoantibodies against the hemidesmosomal proteins, BP180 and BP230. In addition to IgG, IgE has been shown to play a role in the disease. However, the association between disease activity and IgE specific to the NC16A domain of BP180 in blister fluid remains unclear.

Photodynamic therapy in combination with CO2 laser for the treatment of Bowen's disease.

Photodynamic therapy (PDT) involves the activation of a previously administered photosensitizing agent by visible light to induce tumor necrosis. Photosensitizers are topically applied in the treatment of skin tumors to avoid systemic side effects. In this study, we evaluated the feasibility and efficacy of aminolevulinic acid (ALA) as a photosensitizer (ALA-PDT) in combination with CO2 laser in the treatment of Bowen's disease (BD; intraepithelial squamous cell carcinoma).

Photodynamic therapy for facial actinic keratosis: a clinical and histological study in Chinese patients.

Background: Photodynamic therapy (PDT) is a promising treatment modality for skin malignancies. Aminolevulinic acid (ALA)-PDT for the treatment of actinic keratosis (AK) has been well studied in Europe and North America. However, there have only been a few clinical studies that have evaluated ALA-PDT for the treatment of AK in Chinese patients.

Eruptive cherry angiomas associated with vitiligo: provoked by topical nitrogen mustard?

We report a 27-year-old man who had suffered with vitiligo for 7 years and with eruptive cherry angiomas within or around the repigmented vitiliginous skin for 2 years. After continual therapy for vitiligo with topical nitrogen mustard in a concentration of 0.001% for 5 years, multiple cherry angiomas erupted within or around the repigmented vitiliginous plaques.