Lentivirus-mediated shRNA interference targeting SLUG inhibits lung cancer growth and metastasis.

Objective: Lung cancer is a deadly cancer, whose kills more people worldwide than any other malignancy. SLUG (SNAI2, Snail2) is involved in the epithelial mesenchymal transition in physiological and in pathological contexts and is implicated in the development and progression of lung cancer.

Methods: We constructed a lentivirus vector with SLUG shRNA (LV-shSLUG).

[Single lung transplantation with concomitant contralateral lung volume reduction for end- stage emphysema].

Objective: To evaluate the effect of single lung transplantation with concomitant contralateral lung volume reduction surgery (LVRS) for the management of end-stage emphysema.

Methods: A 46 year-old patient with end-stage emphysema received right lung transplantation and LVRS through the bilateral anterior-lateral intercostal incisions simultaneously.

Results: Hyperinflation of the native lung or mediastinal shift did not occur after the operation, and the transplanted right lung dilated well without suppression.